FHL2 - four and a half LIM domains 2 Gene

Homo sapiens

Also known as DRAL; AAG11; FHL-2; SLIM3; SLIM-3

Gene ID: 2274 | Gene type: protein coding

About FHL2

Cytogenetic location: 2q12.2 Genomic coordinates (GRCh38): 2:105,357,712-105,438,529 (from NCBI)

This gene has 12 transcripts (splice variants), 280 orthologues, 2 paralogues and is associated with 1 phenotype. Biased expression in heart (RPKM 149.2), ovary (RPKM 139.8) and 13 other tissues.

Summary

This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2016]

FHL2 Products(11)

mRNA	Protein	Name
NM_001039492.3	NP_001034581.1	four and a half LIM domains protein 2 isoform a
NM_001318894.1	NP_001305823.1	four and a half LIM domains protein 2 isoform a
NM_001318895.3	NP_001305824.1	four and a half LIM domains protein 2 isoform a
NM_001318896.2	NP_001305825.1	four and a half LIM domains protein 2 isoform a
NM_001318897.2	NP_001305826.1	four and a half LIM domains protein 2 isoform b
NM_001318898.2	NP_001305827.1	four and a half LIM domains protein 2 isoform b
NM_001318899.2	NP_001305828.1	four and a half LIM domains protein 2 isoform c
NM_001374399.1	NP_001361328.1	four and a half LIM domains protein 2 isoform a
NM_001450.4	NP_001441.4	four and a half LIM domains protein 2 isoform a
NM_201555.3	NP_963849.1	four and a half LIM domains protein 2 isoform a
NM_201557.5	NP_963851.2	four and a half LIM domains protein 2 isoform a

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	10906324	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14550570	GOA
enables transcription factor binding	IPI IPI: Inferred from physical interaction	15692560	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	15692560	GOA
involved in negative regulation of calcineurin-NFAT signaling cascade	IMP IMP: Inferred from mutant phenotype	22851699	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15692560	GOA
involved in response to hormone	IMP IMP: Inferred from mutant phenotype	17975004	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FHL2 Protein Structure

LIM

0
100
200
279 a.a.

Protein Preferred Names

Protein Names

four and a half LIM domains protein 2

LIM domain protein DRAL

FHL2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FHL2	Q14192	KIAA1217	Homo sapiens	Q5T5P2-6	Y2H Array	25416956
Intra	FHL2	Q14192	ZNF131	Homo sapiens	P52739-2	Y2H Prey Pooling	25416956
Intra	FHL2	Q14192	ZNF131	Homo sapiens	P52739-2	Validated Y2H	25416956
Intra	FHL2	Q14192	TRIM74	Homo sapiens	Q86UV6-2	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	TRIM74	Homo sapiens	Q86UV6-2	Validated Y2H	32296183
Intra	FHL2	Q14192	TRIM74	Homo sapiens	Q86UV6-2	Y2H Array	32296183
Intra	FHL2	Q14192	SLAIN1	Homo sapiens	Q8ND83	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	SLAIN1	Homo sapiens	Q8ND83	Validated Y2H	32296183
Intra	FHL2	Q14192	SLAIN1	Homo sapiens	Q8ND83	Y2H Array	32296183
Intra	FHL2	Q14192	GTF2F2	Homo sapiens	P13984	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	GTF2F2	Homo sapiens	P13984	Y2H Array	32296183
Intra	FHL2	Q14192	CSN2	Homo sapiens	W5RWE1	Validated Y2H	25416956
Intra	FHL2	Q14192	CSN2	Homo sapiens	W5RWE1	Y2H Prey Pooling	25416956
Intra	FHL2	Q14192	SNAI1	Homo sapiens	O95863	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	SNAI1	Homo sapiens	O95863	Y2H Array	32296183
Intra	FHL2	Q14192	GAS8	Homo sapiens	O95995	Y2H Array	32296183
Intra	FHL2	Q14192	GAS8	Homo sapiens	O95995	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	KPRP	Homo sapiens	Q5T749	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	KPRP	Homo sapiens	Q5T749	Validated Y2H	32296183
Intra	FHL2	Q14192	KPRP	Homo sapiens	Q5T749	Y2H Array	32296183
Intra	FHL2	Q14192	ABLIM1	Homo sapiens	O14639-4	Y2H Array	32296183
Intra	FHL2	Q14192	ABLIM1	Homo sapiens	O14639-4	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	FOXO1	Homo sapiens	Q12778	Anti Bait CoIP	15692560
Intra	FHL2	Q14192	FOXO1	Homo sapiens	Q12778	Anti Tag CoIP	15692560
Intra	FHL2	Q14192	FOXO1	Homo sapiens	Q12778	Imaging	15692560
Intra	FHL2	Q14192	GOLGA6A	Homo sapiens	Q9NYA3	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	GOLGA6A	Homo sapiens	Q9NYA3	Validated Y2H	32296183
Intra	FHL2	Q14192	GOLGA6A	Homo sapiens	Q9NYA3	Y2H Array	32296183
Intra	FHL2	Q14192	PRDM6	Homo sapiens	Q9NQX0	Validated Y2H	32296183
Intra	FHL2	Q14192	PRDM6	Homo sapiens	Q9NQX0	Y2H Array	32296183
Intra	FHL2	Q14192	PRDM6	Homo sapiens	Q9NQX0	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	IKZF1	Homo sapiens	Q13422-7	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	IKZF1	Homo sapiens	Q13422-7	Y2H Array	32296183
Intra	FHL2	Q14192	BANP	Homo sapiens	Q8N9N5-2	Validated Y2H	32296183
Intra	FHL2	Q14192	ZNF410	Homo sapiens	Q86VK4-3	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	ZNF410	Homo sapiens	Q86VK4-3	Validated Y2H	32296183
Intra	FHL2	Q14192	ZNF410	Homo sapiens	Q86VK4-3	Y2H Array	32296183
Intra	FHL2	Q14192	NRF1	Homo sapiens	Q16656-4	Validated Y2H	32296183
Intra	FHL2	Q14192	ABI1	Homo sapiens	Q8IZP0-5	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	ABI1	Homo sapiens	Q8IZP0-5	Validated Y2H	32296183
Intra	FHL2	Q14192	ABI1	Homo sapiens	Q8IZP0-5	Y2H Array	32296183
Intra	FHL2	Q14192	CCDC198	Homo sapiens	E9PSE9	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	CCDC198	Homo sapiens	E9PSE9	Y2H Array	32296183
Intra	FHL2	Q14192	DLGAP1	Homo sapiens	Q6IS01	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	DLGAP1	Homo sapiens	Q6IS01	Validated Y2H	32296183
Intra	FHL2	Q14192	DLGAP1	Homo sapiens	Q6IS01	Y2H Array	32296183
Intra	FHL2	Q14192	SAXO4	Homo sapiens	Q7Z5V6-2	Y2H Array	32296183
Intra	FHL2	Q14192	SAXO4	Homo sapiens	Q7Z5V6-2	Validated Y2H	32296183
Intra	FHL2	Q14192	SAXO4	Homo sapiens	Q7Z5V6-2	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	BARX2	Homo sapiens	Q9UMQ3	Validated Y2H	32296183
Intra	FHL2	Q14192	VXN	Homo sapiens	Q8TAG6	Y2H Array	32296183
Intra	FHL2	Q14192	VXN	Homo sapiens	Q8TAG6	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	VXN	Homo sapiens	Q8TAG6	Validated Y2H	32296183
Intra	FHL2	Q14192	GLYR1	Homo sapiens	Q49A26-4	Validated Y2H	32296183
Intra	FHL2	Q14192	GLYR1	Homo sapiens	Q49A26-4	Y2H Array	32296183
Intra	FHL2	Q14192	GLYR1	Homo sapiens	Q49A26-4	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	CIMIP1	Homo sapiens	Q9H1P6	Y2H Array	32296183
Intra	FHL2	Q14192	CIMIP1	Homo sapiens	Q9H1P6	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	CIMIP1	Homo sapiens	Q9H1P6	Validated Y2H	32296183
Intra	FHL2	Q14192	MBD3L1	Homo sapiens	Q8WWY6	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	MBD3L1	Homo sapiens	Q8WWY6	Validated Y2H	32296183
Intra	FHL2	Q14192	MBD3L1	Homo sapiens	Q8WWY6	Y2H Array	32296183
Intra	FHL2	Q14192	IFI35	Homo sapiens	P80217-2	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	IFI35	Homo sapiens	P80217-2	Y2H Array	32296183
Intra	FHL2	Q14192	DAPL1	Homo sapiens	A0PJW8	Y2H Array	32296183
Intra	FHL2	Q14192	DAPL1	Homo sapiens	A0PJW8	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	RASL12	Homo sapiens	Q9NYN1	Validated Y2H	32296183
Intra	FHL2	Q14192	RASL12	Homo sapiens	Q9NYN1	Y2H Array	32296183
Intra	FHL2	Q14192	RASL12	Homo sapiens	Q9NYN1	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	PRDM11	Homo sapiens	Q9NQV5	Validated Y2H	32296183
Intra	FHL2	Q14192	PRDM11	Homo sapiens	Q9NQV5	Y2H Array	32296183
Intra	FHL2	Q14192	PRDM11	Homo sapiens	Q9NQV5	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	PKNOX1	Homo sapiens	P55347	Y2H Array	32296183
Intra	FHL2	Q14192	PKNOX1	Homo sapiens	P55347	Anti Tag CoIP	33961781
Intra	FHL2	Q14192	PKNOX1	Homo sapiens	P55347	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	ID3	Homo sapiens	Q02535	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	ID3	Homo sapiens	Q02535	Y2H Array	32296183
Intra	FHL2	Q14192	POGZ	Homo sapiens	Q7Z3K3	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	ANKRD55	Homo sapiens	Q3KP44	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	ANKRD55	Homo sapiens	Q3KP44	Validated Y2H	32296183
Intra	FHL2	Q14192	ANKRD55	Homo sapiens	Q3KP44	Y2H Array	32296183
Intra	FHL2	Q14192	PRR5L	Homo sapiens	Q6MZQ0	Validated Y2H	32296183
Intra	FHL2	Q14192	PRR5L	Homo sapiens	Q6MZQ0	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	PRR5L	Homo sapiens	Q6MZQ0	Y2H Array	32296183
Intra	FHL2	Q14192	IL16	Homo sapiens	Q14005-2	Y2H Array	32296183
Intra	FHL2	Q14192	IL16	Homo sapiens	Q14005-2	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	AMOT	Homo sapiens	A2BDD9	Y2H Array	32296183
Intra	FHL2	Q14192	AMOT	Homo sapiens	A2BDD9	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	SIRT1	Homo sapiens	Q96EB6	Anti Tag CoIP	15692560
Intra	FHL2	Q14192	TXNRD3NB	Homo sapiens	Q6F5E7	Validated Y2H	32296183
Intra	FHL2	Q14192	TXNRD3NB	Homo sapiens	Q6F5E7	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	TXNRD3NB	Homo sapiens	Q6F5E7	Y2H Array	32296183
Intra	FHL2	Q14192	ZNF85	Homo sapiens	Q49A12	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	ZNF85	Homo sapiens	Q49A12	Y2H Array	32296183
Intra	FHL2	Q14192	ZNF85	Homo sapiens	Q49A12	Validated Y2H	32296183
Intra	FHL2	Q14192	SAXO2	Homo sapiens	Q658L1	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	SAXO2	Homo sapiens	Q658L1	Validated Y2H	32296183
Intra	FHL2	Q14192	SAXO2	Homo sapiens	Q658L1	Y2H Array	32296183
Intra	FHL2	Q14192	TNKS1BP1	Homo sapiens	Q9C0C2	Anti Tag CoIP	33961781
Intra	FHL2	Q14192	ZMYM4	Homo sapiens	Q5VZL5	Validated Y2H	25416956
Intra	FHL2	Q14192	NRF1	Homo sapiens	Q16656	Validated Y2H	25416956
Intra	FHL2	Q14192	NRF1	Homo sapiens	Q16656	Anti Tag CoIP	33961781
Intra	FHL2	Q14192	BLZF1	Homo sapiens	Q9H2G9	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	BLZF1	Homo sapiens	Q9H2G9	Validated Y2H	32296183
Intra	FHL2	Q14192	BLZF1	Homo sapiens	Q9H2G9	Y2H Array	32296183
Intra	FHL2	Q14192	BLZF1	Homo sapiens	Q9H2G9	Y2H Prey Pooling	25416956
Intra	FHL2	Q14192	MISP	Homo sapiens	Q8IVT2	Validated Y2H	32296183
Intra	FHL2	Q14192	KANK2	Homo sapiens	Q63ZY3	Validated Y2H	25416956
Intra	FHL2	Q14192	KANK2	Homo sapiens	Q63ZY3	Validated Y2H	32296183
Intra	FHL2	Q14192	KANK2	Homo sapiens	Q63ZY3	Y2H Array	25416956
Intra	FHL2	Q14192	KANK2	Homo sapiens	Q63ZY3	Y2H Array	32296183
Intra	FHL2	Q14192	KANK2	Homo sapiens	Q63ZY3	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	PKNOX2	Homo sapiens	Q96KN3	Validated Y2H	32296183
Intra	FHL2	Q14192	PKNOX2	Homo sapiens	Q96KN3	Y2H Array	32296183
Intra	FHL2	Q14192	PKNOX2	Homo sapiens	Q96KN3	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	QRICH1	Homo sapiens	Q2TAL8	Validated Y2H	32296183
Intra	FHL2	Q14192	QRICH1	Homo sapiens	Q2TAL8	Anti Tag CoIP	33961781
Intra	FHL2	Q14192	PICALM	Homo sapiens	Q13492	Pull Down	22829078
Intra	FHL2	Q14192	GLYR1	Homo sapiens	Q49A26	Validated Y2H	25416956
Intra	FHL2	Q14192	GLYR1	Homo sapiens	Q49A26	Y2H Array	25416956
Intra	FHL2	Q14192	GLYR1	Homo sapiens	Q49A26	Y2H Prey Pooling	25416956
Intra	FHL2	Q14192	A1CF	Homo sapiens	Q9NQ94	Validated Y2H	32296183
Intra	FHL2	Q14192	SIGLEC6	Homo sapiens	O43699	Y2H Prey Pooling	25416956
Intra	FHL2	Q14192	SIGLEC6	Homo sapiens	O43699	Validated Y2H	25416956
Intra	FHL2	Q14192	SIGLEC6	Homo sapiens	O43699	Y2H Array	25416956
Intra	FHL2	Q14192	ZNF143	Homo sapiens	P52747	Y2H Array	32296183
Intra	FHL2	Q14192	ZNF143	Homo sapiens	P52747	Anti Tag CoIP	33961781
Intra	FHL2	Q14192	ZNF143	Homo sapiens	P52747	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	ZNF131	Homo sapiens	P52739	Anti Tag CoIP	33961781
Intra	FHL2	Q14192	SP1	Homo sapiens	P08047	Anti Tag CoIP	33961781
Intra	FHL2	Q14192	SP1	Homo sapiens	P08047	Pull Down	16624878
Intra	FHL2	Q14192	REL	Homo sapiens	Q04864	Validated Y2H	25416956
Intra	FHL2	Q14192	ZNF408	Homo sapiens	Q9H9D4	Y2H	18255255
Intra	FHL2	Q14192	BRCA1	Homo sapiens	P38398	Y2H	21988832
Intra	FHL2	Q14192	BRCA1	Homo sapiens	P38398	Pull Down	14550570
Intra	FHL2	Q14192	SPRY4	Homo sapiens	Q9C004	Validated Y2H	32296183
Intra	FHL2	Q14192	SPRY4	Homo sapiens	Q9C004	Y2H Array	32296183
Intra	FHL2	Q14192	SPRY4	Homo sapiens	Q9C004	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	GNG12	Homo sapiens	Q9UBI6	Validated Y2H	32296183
Intra	FHL2	Q14192	GNG12	Homo sapiens	Q9UBI6	Y2H Prey Pooling	25416956
Intra	FHL2	Q14192	GNG12	Homo sapiens	Q9UBI6	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	GNG12	Homo sapiens	Q9UBI6	Y2H Array	32296183
Intra	FHL2	Q14192	GNG12	Homo sapiens	Q9UBI6	Y2H Array	25416956
Intra	FHL2	Q14192	DCP1A	Homo sapiens	Q9NPI6	Y2H Array	31515488
Intra	FHL2	Q14192	DCP1A	Homo sapiens	Q9NPI6	Validated Y2H	25416956
Intra	FHL2	Q14192	DCP1A	Homo sapiens	Q9NPI6	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	DCP1A	Homo sapiens	Q9NPI6	Validated Y2H	32296183
Intra	FHL2	Q14192	DCP1A	Homo sapiens	Q9NPI6	Y2H Array	32296183
Intra	FHL2	Q14192	ZNF200	Homo sapiens	P98182	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	ZNF200	Homo sapiens	P98182	Y2H Array	32296183
Intra	FHL2	Q14192	TCP10L	Homo sapiens	Q8TDR4	Validated Y2H	32296183
Intra	FHL2	Q14192	TCP10L	Homo sapiens	Q8TDR4	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	TCP10L	Homo sapiens	Q8TDR4	Y2H Array	32296183
Intra	FHL2	Q14192	SAXO1	Homo sapiens	Q8IYX7	Validated Y2H	25416956
Intra	FHL2	Q14192	SAXO1	Homo sapiens	Q8IYX7	Y2H Array	25416956
Intra	FHL2	Q14192	SAXO1	Homo sapiens	Q8IYX7	Y2H Array	31515488
Intra	FHL2	Q14192	ZNF620	Homo sapiens	Q6ZNG0	Y2H Array	32296183
Intra	FHL2	Q14192	ZNF620	Homo sapiens	Q6ZNG0	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	ZNF620	Homo sapiens	Q6ZNG0	Validated Y2H	32296183
Intra	FHL2	Q14192	SREBF2	Homo sapiens	Q12772	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	SREBF2	Homo sapiens	Q12772	Y2H Array	32296183
Intra	FHL2	Q14192	SREBF2	Homo sapiens	Q12772	Anti Tag CoIP	33961781
Intra	FHL2	Q14192	LRIF1	Homo sapiens	Q5T3J3	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	LRIF1	Homo sapiens	Q5T3J3	Y2H Array	32296183
Intra	FHL2	Q14192	LRIF1	Homo sapiens	Q5T3J3	Validated Y2H	32296183
Intra	FHL2	Q14192	AKIP1	Homo sapiens	Q9NQ31	Y2H Array	32296183
Intra	FHL2	Q14192	AKIP1	Homo sapiens	Q9NQ31	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	AKIP1	Homo sapiens	Q9NQ31	Validated Y2H	32296183
Intra	FHL2	Q14192	PHF1	Homo sapiens	O43189	Y2H Array	32296183
Intra	FHL2	Q14192	PHF1	Homo sapiens	O43189	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	CAND2	Homo sapiens	O75155	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	CAND2	Homo sapiens	O75155	Y2H Array	32296183
Intra	FHL2	Q14192	MAGEL2	Homo sapiens	Q9UJ55	Y2H Array	32296183
Intra	FHL2	Q14192	MAGEL2	Homo sapiens	Q9UJ55	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	MAGEL2	Homo sapiens	Q9UJ55	Validated Y2H	32296183
Intra	FHL2	Q14192	ZNF655	Homo sapiens	Q8N720	Validated Y2H	32296183
Intra	FHL2	Q14192	ZNF655	Homo sapiens	Q8N720	Y2H Array	32296183
Intra	FHL2	Q14192	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	GABPA	Homo sapiens	Q06546	Pull Down	16624878
Intra	FHL2	Q14192	GABPA	Homo sapiens	Q06546	Anti Tag CoIP	33961781
Intra	FHL2	Q14192	GNG4	Homo sapiens	P50150	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	GNG4	Homo sapiens	P50150	Y2H Array	32296183
Intra	FHL2	Q14192	INCA1	Homo sapiens	Q0VD86	Y2H Array	31515488
Intra	FHL2	Q14192	NIBAN1	Homo sapiens	Q9BZQ8	Validated Y2H	25416956
Intra	FHL2	Q14192	NIBAN1	Homo sapiens	Q9BZQ8	Validated Y2H	32296183
Intra	FHL2	Q14192	NIBAN1	Homo sapiens	Q9BZQ8	Y2H Array	25416956
Intra	FHL2	Q14192	RFX3	Homo sapiens	P48380	Y2H	21516116
Intra	FHL2	Q14192	RFX3	Homo sapiens	P48380	Validated Y2H	25416956
Intra	FHL2	Q14192	RFX3	Homo sapiens	P48380	Y2H Prey Pooling	25416956
Intra	FHL2	Q14192	RFX3	Homo sapiens	P48380	Y2H Array	29892012
Intra	FHL2	Q14192	RFX3	Homo sapiens	P48380	Anti Tag CoIP	33961781
Intra	FHL2	Q14192	JUP	Homo sapiens	P14923	Validated Y2H	25416956
Intra	FHL2	Q14192	JUP	Homo sapiens	P14923	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	JUP	Homo sapiens	P14923	Y2H Array	25416956
Intra	FHL2	Q14192	JUP	Homo sapiens	P14923	Y2H Array	32296183
Intra	FHL2	Q14192	JUP	Homo sapiens	P14923	Y2H Prey Pooling	25416956
Intra	FHL2	Q14192	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	FHL2	Q14192	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	ZFP64	Homo sapiens	Q9NTW7	Validated Y2H	25416956
Intra	FHL2	Q14192	ZFP64	Homo sapiens	Q9NTW7	Y2H Array	25416956
Intra	FHL2	Q14192	ZFP64	Homo sapiens	Q9NTW7	Y2H Prey Pooling	25416956
Intra	FHL2	Q14192	ZFP64	Homo sapiens	Q9NTW7	Y2H Array	29892012
Intra	FHL2	Q14192	ATF3	Homo sapiens	P18847	Y2H	18255255
Intra	FHL2	Q14192	ATF3	Homo sapiens	P18847	Anti Tag CoIP	18255255
Intra	FHL2	Q14192	GTF2H1	Homo sapiens	P32780	Y2H Array	32296183
Intra	FHL2	Q14192	GTF2H1	Homo sapiens	P32780	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	DEAF1	Homo sapiens	O75398	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	DEAF1	Homo sapiens	O75398	Y2H Array	32296183
Intra	FHL2	Q14192	CCDC92	Homo sapiens	Q53HC0	Y2H Array	31515488
Intra	FHL2	Q14192	CCDC92	Homo sapiens	Q53HC0	Validated Y2H	25416956
Intra	FHL2	Q14192	CCDC92	Homo sapiens	Q53HC0	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	CCDC92	Homo sapiens	Q53HC0	Y2H Prey Pooling	25416956
Intra	FHL2	Q14192	CCDC92	Homo sapiens	Q53HC0	Validated Y2H	32296183
Intra	FHL2	Q14192	CCDC92	Homo sapiens	Q53HC0	Y2H Array	25416956
Intra	FHL2	Q14192	CCDC92	Homo sapiens	Q53HC0	Y2H Array	32296183
Intra	FHL2	Q14192	ZNF76	Homo sapiens	P36508	Y2H Array	32296183
Intra	FHL2	Q14192	ZNF76	Homo sapiens	P36508	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	C2CD6	Homo sapiens	Q53TS8	Validated Y2H	32296183
Intra	FHL2	Q14192	DTX2	Homo sapiens	Q86UW9	Validated Y2H	25416956
Intra	FHL2	Q14192	ZNF417	Homo sapiens	Q8TAU3	Y2H Array	25416956
Intra	FHL2	Q14192	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	FHL2	Q14192	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	FHL2	Q14192	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	SOX30	Homo sapiens	O94993	Y2H Array	32296183
Intra	FHL2	Q14192	SOX30	Homo sapiens	O94993	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	BANP	Homo sapiens	Q8N9N5	Anti Tag CoIP	33961781
Intra	FHL2	Q14192	BANP	Homo sapiens	Q8N9N5	Y2H Array	31515488
Intra	FHL2	Q14192	BANP	Homo sapiens	Q8N9N5	Y2H Prey Pooling	25416956
Intra	FHL2	Q14192	PHF21A	Homo sapiens	Q96BD5	Anti Tag CoIP	33961781
Intra	FHL2	Q14192	PHF21A	Homo sapiens	Q96BD5	Validated Y2H	32296183
Intra	FHL2	Q14192	ATOSB	Homo sapiens	Q7L5A3	Validated Y2H	32296183
Intra	FHL2	Q14192	RAI2	Homo sapiens	Q9Y5P3	Validated Y2H	25416956
Intra	FHL2	Q14192	RAI2	Homo sapiens	Q9Y5P3	Validated Y2H	32296183
Intra	FHL2	Q14192	RAI2	Homo sapiens	Q9Y5P3	Y2H Array	25416956
Intra	FHL2	Q14192	RAI2	Homo sapiens	Q9Y5P3	Y2H Array	32296183
Intra	FHL2	Q14192	RAI2	Homo sapiens	Q9Y5P3	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	LDLRAP1	Homo sapiens	Q5SW96	Validated Y2H	32296183
Intra	FHL2	Q14192	SCNM1	Homo sapiens	Q9BWG6	Validated Y2H	32296183
Intra	FHL2	Q14192	SCNM1	Homo sapiens	Q9BWG6	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	SCNM1	Homo sapiens	Q9BWG6	Y2H Array	32296183
Intra	FHL2	Q14192	ARHGAP9	Homo sapiens	Q9BRR9	Y2H Prey Pooling	25416956
Intra	FHL2	Q14192	ARHGAP9	Homo sapiens	Q9BRR9	Validated Y2H	25416956
Intra	FHL2	Q14192	KLF12	Homo sapiens	Q9Y4X4	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	KLF12	Homo sapiens	Q9Y4X4	Validated Y2H	32296183
Intra	FHL2	Q14192	KLF12	Homo sapiens	Q9Y4X4	Y2H Array	32296183
Intra	FHL2	Q14192	KLF12	Homo sapiens	Q9Y4X4	Anti Tag CoIP	33961781
Intra	FHL2	Q14192	ZSCAN9	Homo sapiens	O15535	Y2H Array	32296183
Intra	FHL2	Q14192	ZSCAN9	Homo sapiens	O15535	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	YY1	Homo sapiens	P25490	Y2H Array	32296183
Intra	FHL2	Q14192	YY1	Homo sapiens	P25490	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	FAM204A	Homo sapiens	Q9H8W3	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	FAM204A	Homo sapiens	Q9H8W3	Validated Y2H	32296183
Intra	FHL2	Q14192	FAM204A	Homo sapiens	Q9H8W3	Y2H Array	32296183
Intra	FHL2	Q14192	SP2	Homo sapiens	Q02086	Y2H Array	25416956
Intra	FHL2	Q14192	SP2	Homo sapiens	Q02086	Anti Tag CoIP	33961781
Intra	FHL2	Q14192	SP2	Homo sapiens	Q02086	Y2H Prey Pooling	25416956
Intra	FHL2	Q14192	SP2	Homo sapiens	Q02086-2	Y2H Array	32296183
Intra	FHL2	Q14192	SP2	Homo sapiens	Q02086-2	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	GATAD2B	Homo sapiens	Q8WXI9	Validated Y2H	32296183
Intra	FHL2	Q14192	GATAD2B	Homo sapiens	Q8WXI9	Y2H Prey Pooling	32296183
Intra	FHL2	Q14192	GATAD2B	Homo sapiens	Q8WXI9	Y2H Array	32296183
Intra	FHL2	Q14192	GMEB2	Homo sapiens	Q9UKD1	Validated Y2H	32296183
Intra	FHL2	Q14192	SPHK1	Homo sapiens	Q9NYA1	Anti Tag CoIP	16888242
Intra	FHL2	Q14192	SPHK1	Homo sapiens	Q9NYA1	Y2H	16888242

Cross: Cross-species interaction Intra: Intraspecies interaction

FHL2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82130	FHL2 Antibody (YA1875)	WB, ICC/IF, IP	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Familial Isolated Dilated Cardiomyopathy

Familial Or Idiopathic Dilated Cardiomyopathy

Rhabdomyosarcoma

Hemophagocytic Lymphohistiocytosis, Familial, 1

Familial Hemophagocytic Lymphohistiocytosis	Fhl
Familial Erythrophagocytic Lymphohistiocytosis	Hemophagocytic Syndrome
FHL1	Hplh1
Hlh1	Fel
Familial Hemophagocytic Lymphohistiocytosis 1	Primary Hemophagocytic Lymphohistiocytosis
Familial Hlh	Hlh
Familial Hemophagocytic Lymphocytosis	Hemophagocytic Lymphohistiocytosis, Familial
Reticulosis, Familial Histiocytic	Hemophagocytic Reticulosis, Familial
Erythrophagocytic Lymphohistiocytosis, Familial	Familial Histiocytic Reticulosis
Familial Hemophagocytic Histiocytosis	Familial Hemophagocytic Reticulosis
Fhlh	Hplh
Primary Hemophagocytic Hymphohistiocytosis	Genetic Hemophagocytic Lymphohistiocytosis
Hemophagocytic Lymphohistiocytosis	Familial Hemophagocytic Lymphohistiocytosis Type 1

Hemophagocytic Lymphohistiocytosis

Lymphohistiocytosis, Hemophagocytic	Haemophagocytic Syndrome
Lymphohistiocytosis Hemophagocytic	Hemophagocytic Syndrome
Familial Hemophagocytic Lymphocytosis	Histiocytoses Of Mononuclear Phagocytes
Haemophagocytic Lymphohistiocytosis Nos

Deafness, Autosomal Recessive 65

DFNB65	Autosomal Recessive Nonsyndromic Deafness 65
Autosomal Recessive Deafness 65

Immunodeficiency 55

Combined Immunodeficiency Due To Gins1 Deficiency	IMD55
Cid Due To Gins1 Deficiency	Combined Immunodeficiency With Intrauterine Growth Retardation-Nk Cell Deficiency-Neutropenia
Combined Immunodeficiency With Intrauterine Growth Retardation-Natural Killer Cell Deficiency-Neutropenia

Hemophagocytic Lymphohistiocytosis, Familial, 2

Familial Hemophagocytic Lymphohistiocytosis 2	FHL2
Hplh2	Hlh2
Hemophagocytic Lymphohistiocytosis, Familial, 2, Susceptibility To	Lymphohistiocytosis, Hemophagocytic, Familial, Type 2

Hemophagocytic Lymphohistiocytosis, Familial, 4

Familial Hemophagocytic Lymphohistiocytosis 4	FHL4
Hplh4	Hlh4
Lymphohistiocytosis, Hemophagocytic, Familial, Type 4

Griscelli Syndrome

Chediak-Higashi-Like Syndrome	Griscelli-Prunieras Syndrome
Partial Albinism-Immunodeficiency Syndrome	Griscelli Disease
Gs	Hypopigmentation Immunodeficiency Disease
Partial Albinism With Immunodeficiency	Immunodeficiency Syndrome With Hypopigmentation
Hypopigmentation-Immunodeficiency Disease

Griscelli Syndrome, Type 2

Griscelli Syndrome Type 2	GS2
Griscelli Syndrome With Hemophagocytic Syndrome	Partial Albinism And Immunodeficiency Syndrome
Paid Syndrome	Hypopigmentation-Immunodeficiency With Or Without Neurologic Impairment Syndrome
Griscelli-Prunieras Syndrome Type 2	Griscelli-Pruniéras Syndrome Type 2
Griscelli Syndrome 2

Lymphoproliferative Syndrome, X-Linked, 2

XLP2	Xiap Deficiency
X-Linked Lymphoproliferative Syndrome 2	X-Linked Lymphoproliferative Disease Due To Xiap Deficiency
Xiap-Related Lymphoproliferative Disease, X-Linked	X-Linked Lymphoproliferative Syndrome Type 2
Xiap Deficiency Syndrome

Immunodeficiency 51

IMD51	Candf5
Candidiasis, Familial, 5	Candidiasis, Familial, 5, Formerly
Candf5, Formerly	Familial Candidiasis 5
Candidiasis Familial 5 Autosomal Recessive	Candidiasis Familial Chronic Mucocutaneous Autosomal Recessive
Chronic Mucocutaneous Candidiasis 5

Retinitis Pigmentosa 90

RP90	Retinitis Pigmentosa, Type 90

Scapuloperoneal Myopathy

Myopathy, X-Linked, With Postural Muscle Atrophy

Emery-Dreifuss Muscular Dystrophy 6, X-Linked	XMPMA
X-Linked Myopathy With Postural Muscle Atrophy	X-Linked Emery-Dreifuss Muscular Dystrophy 6
EDMD6	Emd6

Lymphoproliferative Syndrome, X-Linked, 1

Lymphomatoid Papulosis	Duncan Disease
Purtilo Syndrome	X-Linked Lymphoproliferative Syndrome
Xlp	X-Linked Lymphoproliferative Disease
XLP1	Lyp
Lymphoproliferative Disease, X-Linked	Xlpd
X-Linked Lymphoproliferative Disease Due To Sh2d1a Deficiency	Ebv Infection, Severe, Susceptibility To
Ebvs	Immunodeficiency 5
Imd5	X-Linked Lymphoproliferative Syndrome 1
Epstein-Barr Virus Infection, Familial Fatal	Ebv Infection, Severe
Infectious Mononucleosis, Severe	Infectious Mononucleosis, Severe, Susceptibility To
Immunodeficiency, X-Linked Progressive Combined Variable	Epstein Barr Virus Infection, Familial Fatal
X-Linked Progressive Combined Variable Immunodeficiency 5	Epstein-Barr Virus-Induced Lymphoproliferative Disease In Males
Familial Fatal Epstein-Barr Infection	Severe Susceptibility To Ebv Infection
Severe Susceptibility To Infectious Mononucleosis	Sap Deficiency
Sh2d1a/Slam-Associated Protein Deficiency	X-Linked Lymphoproliferative Syndrome Type 1
X-Linked Progressive Combined Variable Immunodeficiency	Lymphoproliferative Syndrome, X-Linked
Sap	X-Linked Lymphoproliferative Disorder

Chediak-Higashi Syndrome

CHS	Chédiak-Higashi Syndrome
Chediak - Steinbrinck Anomaly	Chediak Higashi Syndrome
Chediak-Steinbrinck-Higashi Syndrome	Oculocutaneous Albinism With Leukocyte Defect
Chediak-Higashi Disease	Chediak-Higashi-Steinbrink Syndrome

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Hermansky-Pudlak Syndrome

Hps	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells
Hermanski-Pudlak Syndrome	Hermansky Pudlak Syndrome
Platelet Storage Pool Deficiency

Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy	Cardiomyopathy, Hypertrophic
Cardiomyopathy Hypertrophic Obstructive	Cardiomyopathy, Hypertrophic, Familial
Idiopathic Myocardial Hypertrophy	Idiopathic Hypertrophic Cardiomyopathy
Obstructive Idiopathic Hypertrophic Cardiomyopathy	Obstructive Cardiomyopathy
Idiopathic Hypertrophic Subaortic Stenosis	Muscular Subaortic Stenosis
Hypertrophic Obstructive Subaortic Stenosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04935	FHL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FHL2	MGD	MGI:1338762
Rattus norvegicus	FHL2	RGD	RGD:61963
Bos taurus	FHL2	VGNC	VGNC:29000
Canis familiaris	FHL2	VGNC	VGNC:40872
Felis catus	FHL2	VGNC	VGNC:62265
Macaca mulatta	FHL2	VGNC	VGNC:72661
Others	FHL2	NCBI

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