2. Gene
  3. GNG5 - G protein subunit gamma 5 Gene

GNG5 - G protein subunit gamma 5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 2787 | Gene type: protein coding

About GNG5

Cytogenetic location: 1p22.3 Genomic coordinates (GRCh38): 1:84,498,325-84,506,581 (from NCBI)

This gene has 5 transcripts (splice variants), 176 orthologues and 11 paralogues. Ubiquitous expression in colon (RPKM 64.2), bone marrow (RPKM 52.7) and 25 other tissues.

Summary

G proteins are trimeric (alpha-beta-gamma) membrane-associated proteins that regulate flow of information from cell surface receptors to a variety of internal metabolic effectors. Interaction of a G protein with its activated receptor promotes exchange of GTP for GDP that is bound to the alpha subunit. The alpha-GTP complex dissociates from the beta-gamma heterodimer so that the subunits, in turn, may interact with and regulate effector molecules (Gilman, 1987 [PubMed 3113327]; summary by Ahmad et al., 1995) [PubMed 7606925].[supplied by OMIM, Nov 2010]

GNG5 Products(1)

mRNA Protein Name
NM_005274.3 NP_005265.1 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables PDZ domain binding IDA
IDA: Inferred from direct assay
23209302 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GNG5 Protein Structure

G-gamma

G-gamma: GGL domain (6 - 66)

  • 0
  • 68 a.a.
Protein Preferred Names Protein Names

guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5

guanine nucleotide binding protein (G protein), gamma 5

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05559 GNG5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus GNG5 RGD RGD:620807
Macaca mulatta GNG5 VGNC VGNC:106373
Mus musculus GNG5 MGD MGI:109164
Canis familiaris GNG5 VGNC VGNC:41321