GNG5 - G protein subunit gamma 5 Gene

Homo sapiens

Gene ID: 2787 | Gene type: protein coding

About GNG5

Cytogenetic location: 1p22.3 Genomic coordinates (GRCh38): 1:84,498,325-84,506,581 (from NCBI)

This gene has 5 transcripts (splice variants), 176 orthologues and 11 paralogues. Ubiquitous expression in colon (RPKM 64.2), bone marrow (RPKM 52.7) and 25 other tissues.

Summary

G proteins are trimeric (alpha-beta-gamma) membrane-associated proteins that regulate flow of information from cell surface receptors to a variety of internal metabolic effectors. Interaction of a G protein with its activated receptor promotes exchange of GTP for GDP that is bound to the alpha subunit. The alpha-GTP complex dissociates from the beta-gamma heterodimer so that the subunits, in turn, may interact with and regulate effector molecules (Gilman, 1987 [PubMed 3113327]; summary by Ahmad et al., 1995) [PubMed 7606925].[supplied by OMIM, Nov 2010]

GNG5 Products(1)

mRNA	Protein	Name
NM_005274.3	NP_005265.1	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables PDZ domain binding	IDA IDA: Inferred from direct assay	23209302	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GNG5 Protein Structure

G-gamma

0
68 a.a.

Protein Preferred Names

Protein Names

guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5

guanine nucleotide binding protein (G protein), gamma 5

GNG5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GNG5	P63218	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	25416956
Intra	GNG5	P63218	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	GNG5	P63218	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
Intra	GNG5	P63218	AMOTL2	Homo sapiens	Q9Y2J4-4	Validated Y2H	25416956
Intra	GNG5	P63218	GNB1	Homo sapiens	P62873	Anti Tag CoIP	33961781
Intra	GNG5	P63218	TRAF1	Homo sapiens	Q13077	Y2H Array	25416956
Intra	GNG5	P63218	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	25416956
Intra	GNG5	P63218	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	GNG5	P63218	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
Intra	GNG5	P63218	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
Intra	GNG5	P63218	KRT31	Homo sapiens	Q15323	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05559	GNG5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GNG5	RGD	RGD:620807
Macaca mulatta	GNG5	VGNC	VGNC:106373
Mus musculus	GNG5	MGD	MGI:109164
Canis familiaris	GNG5	VGNC	VGNC:41321

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