GOT1 - glutamic-oxaloacetic transaminase 1 Gene

Homo sapiens

Also known as AST; AST1; SGOT; cCAT; GIG18; cAspAT; ASTQTL1

Gene ID: 2805 | Gene type: protein coding

About GOT1

Cytogenetic location: 10q24.2 Genomic coordinates (GRCh38): 10:99,396,870-99,430,624 (from NCBI)

This gene has 3 transcripts (splice variants), 274 orthologues, 2 paralogues and is associated with 1 phenotype. Broad expression in heart (RPKM 196.1), liver (RPKM 87.7) and 14 other tissues.

Summary

Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent Enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two Enzymes are homodimeric and show close homology. [provided by RefSeq, Jul 2008]

GOT1 Products(1)

mRNA	Protein	Name
NM_002079.3	NP_002070.1	aspartate aminotransferase, cytoplasmic

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables L-aspartate:2-oxoglutarate aminotransferase activity	IDA IDA: Inferred from direct assay	2182221	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in aspartate catabolic process	IDA IDA: Inferred from direct assay	2241899	GOA
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	8396422	GOA
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	8396422	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	7060339	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GOT1 Protein Structure

Aminotran_1_2

0
100
200
300
413 a.a.

Protein Preferred Names

Protein Names

aspartate aminotransferase, cytoplasmic

aspartate aminotransferase 1

Recombinant GOT1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7611	GOT1 Protein, Human (His)	P17174-1 (A2-Q413)	≥95%

GOT1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82430	Aspartate Aminotransferase Antibody (YA2175)	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Aspartate Aminotransferase, Serum Level Of, Quantitative Trait Locus 1

Astqtl1

Aspartate Aminotransferase, Serum Level Of, Qtl1

Siderosis

Pulmonary Siderosis	Deposition Of Iron
Arc-Welders' Disease	Arc-Welders' Lung
Arc-Welders' Nodulation	Arc-Welders' Pneumoconiosis
Iron Oxide Lung	Iron Pneumoconiosis
Pneumoconiosis Siderotico	Siderotic Lung Disease
Steel Grinders' Disease	Welders' Lung
Welders' Siderosis	Lung Fibrosis With Siderosis

Acute Thyroiditis

Infectious Thyroiditis

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Hepatic Coma

Hepatic Encephalopathy

Hepatocerebral Intoxication

Hemophagocytic Lymphohistiocytosis, Familial, 3

Familial Hemophagocytic Lymphohistiocytosis 3	FHL3
Hplh3	Hlh3
Lymphohistiocytosis, Hemophagocytic, Familial, Type 3

Osteopetrosis

Marble Bone Disease	Albers-Schonberg Disease
Osteopetroses	Marble Bones
Osteopetrosis And Related Disorders	Congenital Osteopetrosis
Marble Bone	Albers-Schoenberg Disease
Albers-Schonberg Osteopetrosis	Osteosclerosis Fragilis
Ivory Bones

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Myelodysplastic Syndrome

Myelodysplastic Syndromes	Myelodysplasia
MDS	Myelodysplastic Syndrome Included
Myelodysplastic Syndrome, Susceptibility To, Included	Myelodysplastic Syndrome, Somatic
Myelodysplastic Syndrome, Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-B0091	Adapalene	99.98%	Yes
HY-B0091R	Adapalene (Standard)	/	Unkown
HY-B0091A	Adapalene sodium salt	/	Unkown

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122723	GOT1 inhibitor-1	Inhibitor	99.45%	Unkown
HY-160818	MC3138	Activator	99.27%	Unkown
HY-124825	iGOT1-01	Inhibitor	99.77%	Unkown
HY-N6237	Aspulvinone O		≥96.0%	Unkown
HY-RS05605	GOT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-B0091S	Adapalene-d3		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GOT1	VGNC	VGNC:67398
Rattus norvegicus	GOT1	RGD	RGD:2721
Bos taurus	GOT1	VGNC	VGNC:29501
Canis familiaris	GOT1	VGNC	VGNC:41354
Macaca mulatta	GOT1	VGNC	VGNC:73111
Mus musculus	GOT1	MGD	MGI:95791
Others	GOT1	NCBI

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