1. Gene
  2. GOT1 - glutamic-oxaloacetic transaminase 1 Gene

GOT1 - glutamic-oxaloacetic transaminase 1 Gene

Homo sapiens

Also known as AST; AST1; SGOT; cCAT; GIG18; cAspAT; ASTQTL1

Gene ID: 2805 | Gene type: protein coding

About GOT1

Cytogenetic location: 10q24.2 Genomic coordinates (GRCh38): 10:99,396,870-99,430,624 (from NCBI)

This gene has 3 transcripts (splice variants), 274 orthologues, 2 paralogues and is associated with 1 phenotype. Broad expression in heart (RPKM 196.1), liver (RPKM 87.7) and 14 other tissues.

Summary

Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent Enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two Enzymes are homodimeric and show close homology. [provided by RefSeq, Jul 2008]

GOT1 Products(1)

mRNA Protein Name
NM_002079.3 NP_002070.1 aspartate aminotransferase, cytoplasmic
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables L-aspartate:2-oxoglutarate aminotransferase activity IDA
IDA: Inferred from direct assay
2182221 GOA
Biological Process GO Annotation Evidence Reference Source
involved in aspartate catabolic process IDA
IDA: Inferred from direct assay
2241899 GOA
involved in cellular response to insulin stimulus IEP
IEP: Inferred from expression pattern
8396422 GOA
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
8396422 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
7060339 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GOT1 Protein Structure

Aminotran_1_2

Aminotran_1_2: Aminotransferase class I and II (32 - 405)

  • 0
  • 100
  • 200
  • 300
  • 413 a.a.
Protein Preferred Names Protein Names

aspartate aminotransferase, cytoplasmic

aspartate aminotransferase 1

Recombinant GOT1 Proteins

Cat. No. Product Name Accession Purity
HY-P7611 GOT1 Protein, Human (His) P17174-1 (A2-Q413) ≥95%

GOT1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82430 Aspartate Aminotransferase Antibody (YA2175) WB, IHC-F, IHC-P, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Aspartate Aminotransferase, Serum Level Of, Quantitative Trait Locus 1

Astqtl1

Aspartate Aminotransferase, Serum Level Of, Qtl1

Siderosis

Pulmonary Siderosis

Deposition Of Iron

Arc-Welders' Disease

Arc-Welders' Lung

Arc-Welders' Nodulation

Arc-Welders' Pneumoconiosis

Iron Oxide Lung

Iron Pneumoconiosis

Pneumoconiosis Siderotico

Siderotic Lung Disease

Steel Grinders' Disease

Welders' Lung

Welders' Siderosis

Lung Fibrosis With Siderosis

Acute Thyroiditis

Infectious Thyroiditis

Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Hepatic Coma

Hepatic Encephalopathy

Hepatocerebral Intoxication

Hemophagocytic Lymphohistiocytosis, Familial, 3

Familial Hemophagocytic Lymphohistiocytosis 3

FHL3

Hplh3

Hlh3

Lymphohistiocytosis, Hemophagocytic, Familial, Type 3

Osteopetrosis

Marble Bone Disease

Albers-Schonberg Disease

Osteopetroses

Marble Bones

Osteopetrosis And Related Disorders

Congenital Osteopetrosis

Marble Bone

Albers-Schoenberg Disease

Albers-Schonberg Osteopetrosis

Osteosclerosis Fragilis

Ivory Bones

Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes

Myelodysplastic Syndrome

Myelodysplastic Syndromes

Myelodysplasia

MDS

Myelodysplastic Syndrome Included

Myelodysplastic Syndrome, Susceptibility To, Included

Myelodysplastic Syndrome, Somatic

Myelodysplastic Syndrome, Susceptibility To

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus GOT1 VGNC VGNC:67398
Rattus norvegicus GOT1 RGD RGD:2721
Bos taurus GOT1 VGNC VGNC:29501
Canis familiaris GOT1 VGNC VGNC:41354
Macaca mulatta GOT1 VGNC VGNC:73111
Mus musculus GOT1 MGD MGI:95791
Others GOT1 NCBI