2. Cell Cycle/DNA Damage Epigenetics
  3. Sirtuin
  4. MC3138

MC3138 is a selective SIRT5 activator. MC3138 has antitumor activity on human PDAC cells, with IC50 values of 25.4-236.9 μM. MC3138 combined with Gemcitabine (HY-17026) significantly inhibits tumor growth in mice.

For research use only. We do not sell to patients.

MC3138 Chemical Structure

MC3138 Chemical Structure

CAS No. : 1844889-12-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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10 mM * 1 mL in DMSO In-stock
Solid
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Based on 1 publication(s) in Google Scholar

MC3138 Related Antibodies

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Description

MC3138 is a selective SIRT5 activator. MC3138 has antitumor activity on human PDAC cells, with IC50 values of 25.4-236.9 μM. MC3138 combined with Gemcitabine (HY-17026) significantly inhibits tumor growth in mice[1].

In Vitro

MC3138 (10 μM, 24 h) decreases lysine acetylation of the GOT1 protein and inhibits its enzymatic activity in PDAC cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MC3138 Related Antibodies
Molecular Weight

435.47

Formula

C25H25NO6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CN(C(C2=CC=CC=C2)=O)C=C(C1C3=CC(OC)=CC=C3)C(OCC)=O)OCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (459.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2964 mL 11.4818 mL 22.9637 mL
5 mM 0.4593 mL 2.2964 mL 4.5927 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2964 mL 11.4818 mL 22.9637 mL 57.4092 mL
5 mM 0.4593 mL 2.2964 mL 4.5927 mL 11.4818 mL
10 mM 0.2296 mL 1.1482 mL 2.2964 mL 5.7409 mL
15 mM 0.1531 mL 0.7655 mL 1.5309 mL 3.8273 mL
20 mM 0.1148 mL 0.5741 mL 1.1482 mL 2.8705 mL
25 mM 0.0919 mL 0.4593 mL 0.9185 mL 2.2964 mL
30 mM 0.0765 mL 0.3827 mL 0.7655 mL 1.9136 mL
40 mM 0.0574 mL 0.2870 mL 0.5741 mL 1.4352 mL
50 mM 0.0459 mL 0.2296 mL 0.4593 mL 1.1482 mL
60 mM 0.0383 mL 0.1914 mL 0.3827 mL 0.9568 mL
80 mM 0.0287 mL 0.1435 mL 0.2870 mL 0.7176 mL
100 mM 0.0230 mL 0.1148 mL 0.2296 mL 0.5741 mL
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MC3138 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MC31381844889-12-8MC 3138MC-3138SirtuinPDACGemcitabinetumorGOT1lysine acetylationInhibitorinhibitorinhibit

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