GPR4 - G protein-coupled receptor 4 Gene

Homo sapiens

Also known as GPR6C.l

Gene ID: 2828 | Gene type: protein coding

About GPR4

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:45,589,764-45,602,212 (from NCBI)

This gene has 2 transcripts (splice variants), 141 orthologues and 16 paralogues. Broad expression in fat (RPKM 4.0), lung (RPKM 2.3) and 22 other tissues.

Summary

Enables G protein-coupled receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; positive regulation of Rho protein signal transduction; and response to acidic pH. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

GPR4 Products(1)

mRNA	Protein	Name
NM_005282.3	NP_005273.1	G-protein coupled receptor 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled receptor activity	IMP IMP: Inferred from mutant phenotype	20211729	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	17462861	GOA
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12955148	GOA
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	20211729	GOA
involved in positive regulation of Rho protein signal transduction	IDA IDA: Inferred from direct assay	17462861	GOA
involved in positive regulation of Rho protein signal transduction	IMP IMP: Inferred from mutant phenotype	20211729	GOA
involved in regulation of cell adhesion	IDA IDA: Inferred from direct assay	22110680	GOA
involved in response to acidic pH	IDA IDA: Inferred from direct assay	17462861	GOA
involved in response to acidic pH	IMP IMP: Inferred from mutant phenotype	12955148	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	20211729	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR4 Protein Structure

7tm_1

0
100
200
300
362 a.a.

Protein Preferred Names

Protein Names

G-protein coupled receptor 4

G-protein coupled receptor 19

G-protein coupled receptor 6C.l

Related Diseases

Diseases

Alias

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Epithelial Ovarian Cancer
Neoplasm Of Ovary	Ovarian Neoplasms
Ovarian Cancers	Malignant Neoplasm Of Ovary
Primary Malignant Neoplasm Of Ovary	Ovarian Cancer, Somatic
Malignant Ovarian Tumor	Ovary Neoplasm
Primary Ovarian Cancer	Tumor Of The Ovary
Cancer Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Congenital Central Hypoventilation Syndrome

Cchs	Haddad Syndrome
Ondine Curse	Ondine Syndrome
Congenital Central Hypoventilation	Congenital Central Alveolar Hypoventilation Syndrome
Congenital Failure Of Autonomic Control	Ondine'S Curse
Primary Alveolar Hypoventilation	Ondine-Hirschsprung Disease
Central Congenital Hypoventilation Syndrome	Congenital Ondine Curse
Idiopathic Congenital Central Alveolar Hypoventilation	Congenital Central Alveolar Hypoventilation-Hirschsprung Disease Syndrome
Ondine-Hirschsprung Syndrome

Prolactin Producing Pituitary Tumor

Prolactin-Producing Pituitary Gland Carcinoma	Prolactin-Producing Pituitary Tumor
Malignant Prolactin Producing Neoplasm Of Pituitary Gland	Malignant Prolactinoma
Prolactin Producing Pituitary Tumour	Prolactin Secreting Tumor Of Pituitary
Prolactin Secreting Tumour Of Pituitary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101784	NE 52-QQ57		99.89%	Unkown
HY-101536	GPR4 antagonist 1	Antagonist	98.92%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GPR4	VGNC	VGNC:67427
Macaca mulatta	GPR4	VGNC	VGNC:73136
Canis familiaris	GPR4	VGNC	VGNC:41435
Rattus norvegicus	GPR4	RGD	RGD:1311604
Mus musculus	GPR4	MGD	MGI:2441992
Bos taurus	GPR4	VGNC	VGNC:29587
Others	GPR4	NCBI

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