2. GPCR/G Protein
  3. GPR4
  4. GPR4 antagonist 1

GPR4 antagonist 1 is a GPR4 antagonist, with an IC50 of 189 nM.

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GPR4 antagonist 1 Chemical Structure

GPR4 antagonist 1 Chemical Structure

CAS No. : 1197879-16-5

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10 mM * 1 mL in DMSO USD 638 In-stock
Oil
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Based on 1 publication(s) in Google Scholar

GPR4 antagonist 1 Related Antibodies

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Description

GPR4 antagonist 1 is a GPR4 antagonist, with an IC50 of 189 nM.

IC50 & Target

IC50: 189 nM (GPR4)[1].
Cellular Effect
Cell Line Type Value Description References
HeLa IC50
0.11 μM
Compound: 39c
Antagonist activity at human GPR4 expressed in human HeLa cells assessed as inhibition of pH-induced cAMP accumulation preincubated for 15 mins followed by cAMP addition measured after 60 mins by HTRF method
Antagonist activity at human GPR4 expressed in human HeLa cells assessed as inhibition of pH-induced cAMP accumulation preincubated for 15 mins followed by cAMP addition measured after 60 mins by HTRF method
[PMID: 28689977]
Molecular Weight

431.62

Formula

C27H37N5
CAS No.
Appearance

Oil

Color

Light yellow to yellow

SMILES

CC1=C2C(N(CC3=CC=C(/C=C/CN4CCN(C(C)C)CC4)C=C3)C(CC)=N2)=NC(C)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 98.92%

SDS (252 KB)

COA (245 KB) HNMR (269 KB) LCMS (267 KB)

Handling Instructions (2659 KB)
References
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GPR4 antagonist 1 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GPR4 antagonist 11197879-16-5GPR4G Protein-Coupled Receptor 4Inhibitorinhibitorinhibit

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GPR4 antagonist 1
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HY-101536
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