Mc2r - melanocortin 2 receptor Gene

Rattus norvegicus

Gene ID: 282839 | Gene type: protein coding

About Mc2r

Primary_assembly 18: 62,004,948-62,015,488 reverse strand.mRatBN7.2:CM026991.1

This gene has 1 transcript (splice variant), 178 orthologues, 18 paralogues and is associated with 10 phenotypes. Biased expression in Adrenal (RPKM 393.7) and Muscle (RPKM 25.).

Summary

Predicted to enable G protein-coupled receptor activity. Involved in placenta development. Located in cytoplasm and plasma membrane. Biomarker of toxic shock syndrome. Human ortholog(s) of this gene implicated in West syndrome and glucocorticoid deficiency 1. Orthologous to human MC2R (melanocortin 2 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Mc2r Products(1)

mRNA	Protein	Name
NM_001100491.1	NP_001093961.1	adrenocorticotropic hormone receptor

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in placenta development	IEP IEP: Inferred from expression pattern	15781985	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mc2r Protein Structure

7tmA_MC2R_ACTH_R

0
100
200
296 a.a.

Protein Preferred Names

Protein Names

adrenocorticotropic hormone receptor

melanocortin 2 receptor (adrenocorticotropic hormone)

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1477A	Adrenocorticotropic Hormone (ACTH) (1-39), rat TFA	Agonist	99.84%	Unkown
HY-158081	Atumelnant	Antagonist	98.41%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mc2r	NCBI	NCBI:4158

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