2. GPCR/G Protein Neuronal Signaling
  3. Melanocortin Receptor
  4. Atumelnant

CRN04894 (compound 17h) is an orally active MC2R antagonist that demonstrates in vivo efficacy in rat model of adrenocorticotropic hormone (ACTH)-stimulated corticosterone secretion[1]. CRN04894 binds to human or rat MC2R with KB values of 0.34 nM and 0.23 nM, respsectively.

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Atumelnant Chemical Structure

Atumelnant Chemical Structure

CAS No. : 2392970-97-5

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Description

CRN04894 (compound 17h) is an orally active MC2R antagonist that demonstrates in vivo efficacy in rat model of adrenocorticotropic hormone (ACTH)-stimulated corticosterone secretion[1]. CRN04894 binds to human or rat MC2R with KB values of 0.34 nM and 0.23 nM, respsectively[1].

IC50 & Target[1]

rat MC2R

0.23 nM (Kb)

MC2R

0.34 nM (Kb)

In Vivo

CRN04894 (compound 17h) (3, 30 mg/kg; po; single dose) dose-dependently reduces corticosterone secretion levels in an ACTH-stimulated male rat model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adrenocorticotrophic hormone (ACTH)-stimulated corticosterone secretion in Male Sprague-Dawley Rats[1]
Dosage: 3 mg/kg, 30 mg/kg
Administration: po; single dose; ACTH(1-24) stimulated at 4 hr after CRN04894 treatment.
Result: Significantly decreased the concentration level of corticosterone via oral administration.br/
Molecular Weight

613.71

Formula

C33H42F3N5O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1C[C@H](N(C2=C(N=C(C3=C(C=CC=C3)OCC)C=C2)C(N[C@H]4C5CCN(CC5)C4)=O)CC1)CC)C6(CCC6)C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 98.41%

SDS (251 KB)

COA (256 KB) HNMR (137 KB) RP-HPLC (163 KB) LCMS (107 KB)

Handling Instructions (2659 KB)
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Keywords:

Atumelnant2392970-97-5CRN04894CRN 04894CRN-04894Melanocortin ReceptorMC ReceptorInhibitorinhibitorinhibit

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