GATC - glutamyl-tRNA amidotransferase subunit C Gene

Homo sapiens

Also known as 15E1.2; COXPD42

Gene ID: 283459 | Gene type: protein coding

About GATC

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:120,446,444-120,463,749 (from NCBI)

This gene has 3 transcripts (splice variants), 194 orthologues and is associated with 1 phenotype. Ubiquitous expression in thyroid (RPKM 15.5), lymph node (RPKM 14.0) and 25 other tissues.

Summary

Enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity. Involved in glutaminyl-tRNAGln biosynthesis via transamidation and mitochondrial translation. Located in mitochondrion. Part of glutamyl-tRNA(Gln) amidotransferase complex. Implicated in combined Oxidative Phosphorylation deficiency 42. [provided by Alliance of Genome Resources, Apr 2022]

GATC Products(1)

mRNA	Protein	Name
NM_176818.3	NP_789788.1	glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19805282	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in glutaminyl-tRNAGln biosynthesis via transamidation	IDA IDA: Inferred from direct assay	19805282	GOA
involved in mitochondrial translation	IMP IMP: Inferred from mutant phenotype	19805282	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of glutamyl-tRNA(Gln) amidotransferase complex	IDA IDA: Inferred from direct assay	19805282	GOA
part of glutamyl-tRNA(Gln) amidotransferase complex	IPI IPI: Inferred from physical interaction	19805282	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	19805282	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GATC Protein Structure

Glu-tRNAGln

0
100
136 a.a.

Protein Preferred Names

Protein Names

glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial

glu-AdT subunit C

GATC Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GATC	O43716	CTAG1A	Homo sapiens	P78358	Validated Y2H	32296183
Intra	GATC	O43716	CTAG1A	Homo sapiens	P78358	Y2H Prey Pooling	32296183
Intra	GATC	O43716	CTAG1A	Homo sapiens	P78358	Y2H Array	32296183
Intra	GATC	O43716	TOMM20L	Homo sapiens	Q6UXN7	Validated Y2H	32296183
Intra	GATC	O43716	TOMM20L	Homo sapiens	Q6UXN7	Y2H Array	32296183
Intra	GATC	O43716	TOMM20L	Homo sapiens	Q6UXN7	Y2H Prey Pooling	32296183
Intra	GATC	O43716	SRSF11	Homo sapiens	Q05519-2	Y2H Prey Pooling	32296183
Intra	GATC	O43716	SRSF11	Homo sapiens	Q05519-2	Validated Y2H	32296183
Intra	GATC	O43716	SRSF11	Homo sapiens	Q05519-2	Y2H Array	32296183
Intra	GATC	O43716	QRSL1	Homo sapiens	Q9H0R6	Anti Tag CoIP	33961781
Intra	GATC	O43716	QRSL1	Homo sapiens	Q9H0R6	Anti Tag CoIP	28514442
Intra	GATC	O43716	QRSL1	Homo sapiens	Q9H0R6	GMS	19805282
Intra	GATC	O43716	ALOX5	Homo sapiens	P09917	Y2H Prey Pooling	32296183
Intra	GATC	O43716	ALOX5	Homo sapiens	P09917	Validated Y2H	32296183
Intra	GATC	O43716	ALOX5	Homo sapiens	P09917	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Combined Oxidative Phosphorylation Deficiency 42

COXPD42

Combined Oxidative Phosphorylation Deficiency

Wound Botulism

Cutaneous Infectious Botulism	Cutaneous Toxin-Mediated Botulism
Inoculation Botulism	Skin Infectious Botulism
Skin Toxin-Mediated Botulism

Lactic Acidosis

Acidosis, Lactic

Acidosis Lactic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-148511	Vidutolimod	Agonist	/	Phase 3

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150741	ODN 2216		/	Unkown
HY-RS05299	GATC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GATC	MGD	MGI:1923776
Rattus norvegicus	GATC	RGD	RGD:1309698

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