2. Gene
  3. NPW - neuropeptide W Gene

NPW - neuropeptide W Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as L8; L8C; PPL8; PPNPW

Gene ID: 283869 | Gene type: protein coding

About NPW

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:2,019,785-2,020,755 (from NCBI)

This gene has 2 transcripts (splice variants), 201 orthologues and 1 paralogue. Biased expression in liver (RPKM 2.8), stomach (RPKM 0.8) and 1 other tissue.

Summary

The product of this gene is processed into 23- and 30-amino acid neuropeptides that bind and activate two G-protein coupled receptors in the central nervous system. The neuropeptides have been shown to enhance cortisol secretion from adrenal cells through the Adenylate Cyclase/protein kinase A signaling cascade. The preproprotein is translated using a non-AUG initiation codon that is inferred from analyses of the mouse ortholog. [provided by RefSeq, Jul 2008]

NPW Products(1)

mRNA Protein Name
NM_001099456.3 NP_001092926.2 neuropeptide W preproprotein
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12401809 GOA
Biological Process GO Annotation Evidence Reference Source
involved in G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
12401809 GOA
involved in feeding behavior IDA
IDA: Inferred from direct assay
12959997 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NPW Protein Structure

NPBW

NPBW: Neuropeptides B and W (13 - 134)

  • 0
  • 100
  • 165 a.a.
Protein Preferred Names Protein Names

neuropeptide W

hPPL8

Related Diseases

Diseases Alias
Colorectal Adenocarcinoma

Adenocarcinoma Of Large Intestine
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-108624 CYM 50769 Inhibitor 98.68% Unkown
HY-P10287 Neuropeptide W-30 (human) Agonist / Unkown
HY-P10289 Neuropeptide W-30 (rat) Agonist / Unkown
HY-RS09509 NPW Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NPW RGD RGD:727858
Macaca mulatta NPW VGNC VGNC:75288
Mus musculus NPW MGD MGI:2685781