TMEM102 - transmembrane protein 102 Gene

Homo sapiens

Also known as CBAP

Gene ID: 284114 | Gene type: protein coding

About TMEM102

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,435,435-7,437,679 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 97 orthologues and 9 paralogues. Ubiquitous expression in colon (RPKM 3.0), adrenal (RPKM 2.7) and 24 other tissues.

Summary

Involved in regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; response to cytokine; and signal transduction. Acts upstream of or within positive regulation of T cell migration and positive regulation of cell adhesion. Located in cell surface. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

TMEM102 Products(2)

mRNA	Protein	Name
NM_001320444.1	NP_001307373.1	transmembrane protein 102
NM_178518.3	NP_848613.1	transmembrane protein 102

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17828305	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within positive regulation of T cell migration	IDA IDA: Inferred from direct assay	23620790	GOA
acts upstream of or within positive regulation of cell adhesion	IDA IDA: Inferred from direct assay	23620790	GOA
involved in regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	IDA IDA: Inferred from direct assay	17828305	GOA
involved in response to cytokine	IDA IDA: Inferred from direct assay	17828305	GOA
involved in signal transduction	IDA IDA: Inferred from direct assay	17828305	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	17828305	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	23620790	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM102 Protein Structure

Mab-21

0
100
200
300
400
508 a.a.

Protein Preferred Names

Protein Names

transmembrane protein 102

common beta-chain associated protein

TMEM102 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TMEM102	Q8N9M5	SLC12A4	Homo sapiens	Q9UP95	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14644	TMEM102 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TMEM102	VGNC	VGNC:49837
Macaca mulatta	TMEM102	VGNC	VGNC:99302
Rattus norvegicus	TMEM102	RGD	RGD:1559450
Bos taurus	TMEM102	VGNC	VGNC:35943
Mus musculus	TMEM102	MGD	MGI:1921591
Felis catus	TMEM102	VGNC	VGNC:66254

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