THEM5 - thioesterase superfamily member 5 Gene

Homo sapiens

Also known as ACOT15

Gene ID: 284486 | Gene type: protein coding

About THEM5

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:151,847,101-151,853,712 (from NCBI)

This gene has 2 transcripts (splice variants), 88 orthologues and 1 paralogue. Biased expression in skin (RPKM 49.5) and brain (RPKM 1.6).

Summary

Enables palmitoyl-CoA hydrolase activity. Involved in long-chain fatty-acyl-CoA metabolic process. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022]

THEM5 Products(1)

mRNA	Protein	Name
NM_182578.4	NP_872384.2	acyl-coenzyme A thioesterase THEM5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables long-chain fatty acyl-CoA hydrolase activity	IDA IDA: Inferred from direct assay	22586271	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in long-chain fatty-acyl-CoA metabolic process	IDA IDA: Inferred from direct assay	22586271	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	22586271	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THEM5 Protein Structure

4HBT

0
100
200
247 a.a.

Protein Preferred Names

Protein Names

acyl-coenzyme A thioesterase THEM5

acyl-CoA thioesterase THEM5

THEM5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	THEM5	Q8N1Q8	MAGEA11	Homo sapiens	P43364-2	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Polyneuropathy Due To Drug

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14486	THEM5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	THEM5	RGD	RGD:1562059
Canis familiaris	THEM5	VGNC	VGNC:47342
Mus musculus	THEM5	MGD	MGI:1913448
Felis catus	THEM5	VGNC	VGNC:66160
Bos taurus	THEM5	VGNC	VGNC:50123

Name
Email *

	Sorry, but the email address you supplied was invalid.