GPER1 - G protein-coupled estrogen receptor 1 Gene

Homo sapiens

Also known as mER; CEPR; GPER; DRY12; FEG-1; GPR30; LERGU; LyGPR; CMKRL2; LERGU2; GPCR-Br

Gene ID: 2852 | Gene type: protein coding

About GPER1

Cytogenetic location: 7p22.3 Genomic coordinates (GRCh38): 7:1,087,118-1,093,810 (from NCBI)

This gene has 5 transcripts (splice variants), 191 orthologues and 1 paralogue. Broad expression in fat (RPKM 4.9), kidney (RPKM 3.0) and 22 other tissues.

Summary

This gene encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum and a member of the G-protein coupled receptor 1 family. This receptor binds estrogen and activates multiple downstream signaling pathways, leading to stimulation of Adenylate Cyclase and an increase in cyclic AMP levels, while also promoting intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. This receptor has been shown to play a role in diverse biological processes, including bone and nervous system development, metabolism, cognition, male fertility and uterine function. [provided by RefSeq, Aug 2017]

GPER1 Products(3)

mRNA	Protein	Name
NM_001039966.2	NP_001035055.1	G-protein coupled estrogen receptor 1
NM_001098201.3	NP_001091671.1	G-protein coupled estrogen receptor 1
NM_001505.3	NP_001496.1	G-protein coupled estrogen receptor 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	20551055	GOA
enables nuclear estrogen receptor activity	IDA IDA: Inferred from direct assay	15539556	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20551055	GOA
enables steroid binding	IDA IDA: Inferred from direct assay	15539556	GOA
enables steroid hormone binding	IDA IDA: Inferred from direct assay	19931550	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	23840305	GOA
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	15539556	GOA
involved in cellular response to estradiol stimulus	IDA IDA: Inferred from direct assay	15539556	GOA
involved in cellular response to peptide hormone stimulus	IDA IDA: Inferred from direct assay	21427217	GOA
involved in cellular response to tumor necrosis factor	IDA IDA: Inferred from direct assay	23285008	GOA
involved in negative regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	23840305	GOA
involved in negative regulation of cell cycle process	IMP IMP: Inferred from mutant phenotype	23840305	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23840305	GOA
involved in negative regulation of inflammatory response	IDA IDA: Inferred from direct assay	23285008	GOA
involved in negative regulation of leukocyte activation	IDA IDA: Inferred from direct assay	23285008	GOA
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	23840305	GOA
involved in negative regulation of vascular associated smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	23840305	GOA
involved in nuclear receptor-mediated steroid hormone signaling pathway	IDA IDA: Inferred from direct assay	15705806	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	20551055	GOA
involved in positive regulation of G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	15539556	GOA
involved in positive regulation of cardiac vascular smooth muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	23840305	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	20551055	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	20551055	GOA
involved in positive regulation of epidermal growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	15705806	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23840305	GOA
involved in positive regulation of inositol trisphosphate biosynthetic process	IDA IDA: Inferred from direct assay	15705806	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	15705806	GOA
involved in positive regulation of protein localization to plasma membrane	IDA IDA: Inferred from direct assay	23674134	GOA
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	20551055	GOA
involved in positive regulation of release of sequestered calcium ion into cytosol	IDA IDA: Inferred from direct assay	15705806	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20551055	GOA
involved in positive regulation of uterine smooth muscle contraction	IDA IDA: Inferred from direct assay	21427217	GOA
involved in steroid hormone receptor signaling pathway	IDA IDA: Inferred from direct assay	19931550	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	15705806	GOA
located in cytoplasmic vesicle membrane	IDA IDA: Inferred from direct assay	21540189	GOA
located in early endosome	IDA IDA: Inferred from direct assay	21540189	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	15705806	GOA
located in keratin filament	IDA IDA: Inferred from direct assay	21149639	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	15705806	GOA
located in nucleus	IDA IDA: Inferred from direct assay	20551055	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	21540189	GOA
NOT located in plasma membrane	IDA IDA: Inferred from direct assay	15705806	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	15539556	GOA
located in recycling endosome	IDA IDA: Inferred from direct assay	21540189	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	21540189	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPER1 Protein Structure

7tm_1

0
100
200
300
375 a.a.

Protein Preferred Names

Protein Names

G-protein coupled estrogen receptor 1

G protein-coupled receptor 30

Related Diseases

Diseases

Alias

Teeth Hard Tissue Disease

Amelogenesis Imperfecta, Type Ig

Enamel-Renal Syndrome	Ers
Amelogenesis Imperfecta Type 1g	AI1G
Enamel-Renal-Gingival Syndrome	Amelogenesis Imperfecta And Gingival Fibromatosis Syndrome
Aigfs	Amelogenesis Imperfecta, Hypoplastic, With Nephrocalcinosis
Amelogenesis Imperfecta Hypoplastic With Nephrocalcinosis	Amelogenesis Imperfecta Type Ig
Amelogenesis Imperfecta-Nephrocalcinosis Syndrome	Amelogenesis Imperfecta 1g
Hypoplastic Amelogenesis Imperfecta With Nephrocalcinosis	Amelogenesis Imperfecta Nephrocalcinosis

Adenomyosis

Endometriosis Of Uterus	Endometriosis Interna
Endometriosis Of Myometrium	Endometriosis, Myometrium
Uterine Adenomyosis	Adenomyosis Uteri
Internal Endometriosis

Gynecomastia

Seminoma

Seminoma, Pure

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Estrogen-Receptor Negative Breast Cancer

Estrogen Excess

Hyperestrogenism

Amelogenesis Imperfecta

Ai	Congenital Enamel Hypoplasia
Al - [Amelogenesis Imperfecta]

Endometrial Cancer

Endometrial Carcinoma	Endometrial Neoplasm
Malignant Neoplasm Of Endometrium	Endometrioid Carcinoma
Endometrial Neoplasms	Carcinoma, Endometrioid
Endometrial Cancer, Familial	Endometrial Carcinoma, Somatic
Endometrial Cancer, Susceptibility To	Endometrial Ca
Malignant Endometrial Neoplasm	Neoplasm Of Endometrium
Primary Malignant Neoplasm Of Endometrium	Tumor Of Endometrium
Carcinoma Of The Endometrium	Endometrioid Carcinoma Of Female Reproductive System
ENDMC	Carcinoma Endometrioid
Endometrial Cancers	Cancer, Endometrial
Uterine Corpus Cancer

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Testicular Germ Cell Cancer

Germ Cell Tumor Of Testis	Testicular Germ Cell Tumor
Testicular Germ Cell Neoplasm	Testicular Malignant Germ Cell Tumor

Aromatase Excess Syndrome

AEXS	Increased Aromatase Activity
Familial Hyperestrogenism	Hereditary Prepubertal Gynecomastia
Aromatase Activity, Increased	Familial Gynecomastia Due To Increased Aromatase Activity
Hereditary Gynecomastia	Gynecomastia, Familial
Familial Gynecomastia

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Scoliosis

Premature Menopause

Primary Ovarian Insufficiency	Premature Ovarian Failure
Hypergonadotropic Hypogonadism	Premature Ovarian Insufficiency
Menopause - Premature	Menopause Praecox
Menopause Premature	Menopause, Premature
Female Hypergonadotropic Hypogonadism	Hypergonadotrophic Ovarian Failure
Primary Female Hypogonadism	Pof - [Premature Ovarian Failure]
Ovarian Failure	Ovarian Secretion Suppression
Ovary Hyposecretion	Ovary Secretion Deficiency
Premature Menopause Nos

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05636	GPER1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	GPER1	VGNC	VGNC:73132
Rattus norvegicus	GPER1	RGD	RGD:619845
Canis familiaris	GPER1	VGNC	VGNC:41379
Mus musculus	GPER1	MGD	MGI:1924104
Felis catus	GPER1	VGNC	VGNC:107757
Bos taurus	GPER1	VGNC	VGNC:29532

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