Alox12 - arachidonate 12-lipoxygenase, 12S type Gene

Rattus norvegicus

Also known as 12-LO; 12S-LOX

Gene ID: 287454 | Gene type: protein coding

About Alox12

Primary_assembly 10: 54,958,271-54,970,542 reverse strand.mRatBN7.2:CM026983.1

This gene has 2 transcripts (splice variants), 198 orthologues, 6 paralogues and is associated with 27 phenotypes. Biased expression in Spleen (RPKM 58.3), Uterus (RPKM 42.3) and 8 other tissues.

Summary

Predicted to enable arachidonate 12(S)-lipoxygenase activity; arachidonate 15-lipoxygenase activity; and linoleate 13S-lipoxygenase activity. Involved in several processes, including fatty acid metabolic process; positive regulation of macromolecule metabolic process; and regulation of apoptotic process. Located in cytosol and sarcolemma. Biomarker of congestive heart failure; hypertension; and obesity. Orthologous to human ALOX12 (arachidonate 12-lipoxygenase, 12S type). [provided by Alliance of Genome Resources, Apr 2022]

Alox12 Products(1)

mRNA	Protein	Name
NM_001105798.2	NP_001099268.2	polyunsaturated fatty acid lipoxygenase ALOX12

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in arachidonate metabolic process	IDA IDA: Inferred from direct assay	23382512	RGD
involved in cellular response to lipid	IEP IEP: Inferred from expression pattern	18680775	RGD
involved in hepoxilin biosynthetic process	IDA IDA: Inferred from direct assay	23382512	RGD
involved in lipoxygenase pathway	IDA IDA: Inferred from direct assay	23382512	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	8643560	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	15105833	RGD
involved in positive regulation of blood vessel endothelial cell migration	IMP IMP: Inferred from mutant phenotype	10733500	RGD
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	15105833	RGD
involved in positive regulation of endothelial tube morphogenesis	IMP IMP: Inferred from mutant phenotype	10733500	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	15105833	RGD
involved in positive regulation of mitochondrial depolarization	IMP IMP: Inferred from mutant phenotype	15564577	RGD
involved in positive regulation of reactive oxygen species biosynthetic process	IMP IMP: Inferred from mutant phenotype	15450084	RGD
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	16199435	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in sarcolemma	IDA IDA: Inferred from direct assay	15107407	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Alox12 Protein Structure

PLAT

Lipoxygenase

0
200
400
600
663 a.a.

Protein Preferred Names

Protein Names

polyunsaturated fatty acid lipoxygenase ALOX12

12S-lipoxygenase	arachidonate (12S)-lipoxygenase
arachidonate (15S)-lipoxygenase	arachidonate 15-lipoxygenase,15S-type
linoleate 13S-lipoxygenase	lipoxin synthase 12-LO
platelet 12-LOX	platelet-type lipoxygenase 12

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00612	ALOX12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00613	Alox12 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00614	Alox12 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00615	ALOX12B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Alox12	NCBI	NCBI:239

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