NTMT1 - N-terminal Xaa-Pro-Lys N-methyltransferase 1 Gene

Homo sapiens

Also known as NRMT; NRMT1; NTM1A; AD-003; HOMT1A; C9orf32; METTL11A

Gene ID: 28989 | Gene type: protein coding

About NTMT1

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:129,608,872-129,636,135 (from NCBI)

This gene has 11 transcripts (splice variants), 198 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 16.4), adrenal (RPKM 9.8) and 25 other tissues.

Summary

The METTL11A gene encodes an N-terminal methyltransferase for the RAN (MIM 601179) guanine nucleotide exchange factor regulator of chromosome condensation 1 (RCC1; MIM 179710). METTL11A Enzyme alpha-N-methylates Other protein targets such as SET (MIM 600960) and RB (MIM 180200).[supplied by OMIM, Nov 2010]

NTMT1 Products(9)

mRNA	Protein	Name
NM_001286796.2	NP_001273725.1	N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform a
NM_001286797.2	NP_001273726.1	N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform a
NM_001286798.2	NP_001273727.1	N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform a
NM_001286799.2	NP_001273728.1	N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform a
NM_001286800.2	NP_001273729.1	N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform b
NM_001286801.2	NP_001273730.1	N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform b
NM_001286802.2	NP_001273731.1	N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform c
NM_001286803.2	NP_001273732.1	N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform c
NM_014064.4	NP_054783.2	N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables N-terminal protein N-methyltransferase activity	IDA IDA: Inferred from direct assay	26543159	GOA
enables histone methyltransferase activity	IDA IDA: Inferred from direct assay	26543159	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20668449	GOA
enables protein methyltransferase activity	IDA IDA: Inferred from direct assay	20481588	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in N-terminal peptidyl-glycine methylation	IDA IDA: Inferred from direct assay	26543159	GOA
involved in N-terminal peptidyl-proline dimethylation	IDA IDA: Inferred from direct assay	20481588	GOA
involved in N-terminal peptidyl-serine dimethylation	IDA IDA: Inferred from direct assay	20668449	GOA
involved in N-terminal peptidyl-serine trimethylation	IDA IDA: Inferred from direct assay	20668449	GOA
involved in chromosome segregation	IMP IMP: Inferred from mutant phenotype	20668449	GOA
involved in spindle organization	IMP IMP: Inferred from mutant phenotype	20668449	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	20668449	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NTMT1 Protein Structure

Methyltransf_PK

0
100
200
223 a.a.

Protein Preferred Names

Protein Names

N-terminal Xaa-Pro-Lys N-methyltransferase 1

N-terminal RCC1 methyltransferase

NTMT1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NTMT1	Q9BV86	GLYR1	Homo sapiens	Q49A26-4	Y2H Array	32296183
Intra	NTMT1	Q9BV86	GLYR1	Homo sapiens	Q49A26-4	Y2H Prey Pooling	32296183
Intra	NTMT1	Q9BV86	RCC1	Homo sapiens	P18754	ITC	20668449
Intra	NTMT1	Q9BV86	RCC1	Homo sapiens	P18754	Methyltransferase Ass	20668449

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NTMT1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77447	METTL11A Protein, Human	Q9BV86-1 (T2-R223)	≥95%
HY-P77448	METTL11A Protein, Human (GST)	Q9BV86-1 (T2-R223)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P10028	DC432		/	Unkown
HY-P10407	BM30	Inhibitor	/	Unkown
HY-RS09620	NTMT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NTMT1	VGNC	VGNC:44006
Bos taurus	NTMT1	VGNC	VGNC:32303
Felis catus	NTMT1	VGNC	VGNC:102959
Macaca mulatta	NTMT1	VGNC	VGNC:75451
Mus musculus	NTMT1	MGD	MGI:1913867
Rattus norvegicus	NTMT1	RGD	RGD:1306582
Others	NTMT1	NCBI

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