RCC1 - regulator of chromosome condensation 1 Gene

Homo sapiens

Also known as CHC1; RCC1-I

Gene ID: 1104 | Gene type: protein coding

About RCC1

Cytogenetic location: 1p35.3 Genomic coordinates (GRCh38): 1:28,506,043-28,538,989 (from NCBI)

This gene has 14 transcripts (splice variants), 218 orthologues and 9 paralogues. Ubiquitous expression in testis (RPKM 13.1), lymph node (RPKM 11.7) and 25 other tissues.

Summary

Enables several functions, including guanyl-nucleotide exchange factor activity; nucleosomal DNA binding activity; and protein heterodimerization activity. Involved in several processes, including G1/S transition of mitotic cell cycle; regulation of mitotic nuclear division; and spindle organization. Located in chromatin; cytoplasm; and nucleus. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

RCC1 Products(6)

mRNA	Protein	Name
NM_001048194.4	NP_001041659.1	regulator of chromosome condensation isoform a
NM_001048195.4	NP_001041660.1	regulator of chromosome condensation isoform b
NM_001048199.3	NP_001041664.1	regulator of chromosome condensation isoform c
NM_001269.6	NP_001260.1	regulator of chromosome condensation isoform c
NM_001381865.2	NP_001368794.1	regulator of chromosome condensation isoform c
NM_001381866.2	NP_001368795.1	regulator of chromosome condensation isoform c

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	2677018	GOA
enables guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	1944575	GOA
enables guanyl-nucleotide exchange factor activity	IMP IMP: Inferred from mutant phenotype	11336674	GOA
enables histone binding	IDA IDA: Inferred from direct assay	11375490	GOA
enables nucleosomal DNA binding	IDA IDA: Inferred from direct assay	17435751	GOA
enables nucleosome binding	IMP IMP: Inferred from mutant phenotype	20347844	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	1961752	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	11336674	GOA
enables small GTPase binding	IDA IDA: Inferred from direct assay	11336674	GOA
enables sulfate binding	IDA IDA: Inferred from direct assay	11336674	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	3678831	GOA
involved in chromosome segregation	IMP IMP: Inferred from mutant phenotype	17435751	GOA
involved in mitotic spindle organization	IDA IDA: Inferred from direct assay	15014043	GOA
involved in regulation of mitotic nuclear division	IDA IDA: Inferred from direct assay	15014043	GOA
involved in spindle assembly	IMP IMP: Inferred from mutant phenotype	17435751	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	12121620	GOA
located in condensed nuclear chromosome	IDA IDA: Inferred from direct assay	15014043	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17435751	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17435751	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	11336674	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RCC1 Protein Structure

RCC1

0
100
200
300
421 a.a.

Protein Preferred Names

Protein Names

regulator of chromosome condensation

cell cycle regulatory protein

Related Diseases

Diseases

Alias

Microcystic Meningioma

Raynaud Disease

Raynaud'S Disease	Raynaud Phenomenon
Raynaud'S Syndrome	Raynaud'S
Cold Fingers, Hereditary	Raynaud'S Phenomenon
Raynaud'S Disease/Phenomenon	Raynauds Syndrome
Raynauds Phenomenon	Secondary Raynaud'S Phenomenon
Raynaud Syndrome

Retinitis Pigmentosa 3

RP3	Retinitis Pigmentosa 15
Rp15	Choroidoretinal Degeneration With Retinal Reflex In Heterozygous Women
Cone-Rod Degeneration, X-Linked	Retinitis Pigmentosa Type 15
X-Linked Cone-Rod Degeneration	X-Linked Retinitis Pigmentosa 3
Xlrp3	Xlrp-3
Retinitis Pigmentosa-3	Retinitis Pigmentosa, Type 3

Joubert Syndrome 7

JBTS7	Cerebello-Oculo-Renal Syndrome 3
Cors3	Joubert Syndrome, Type 7

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-119425	Razoxane	Inhibitor	99.16%	Unkown
HY-RS11783	RCC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RCC1	RGD	RGD:1592835
Bos taurus	RCC1	VGNC	VGNC:33825
Macaca mulatta	RCC1	VGNC	VGNC:107115
Felis catus	RCC1	VGNC	VGNC:64544
Mus musculus	RCC1	MGD	MGI:1913989
Canis familiaris	RCC1	VGNC	VGNC:45440
Others	RCC1	NCBI

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