ASTE1 - asteroid homolog 1 Gene

Homo sapiens

Also known as HT001

Gene ID: 28990 | Gene type: protein coding

About ASTE1

This gene has 8 transcripts (splice variants) and 211 orthologues. Ubiquitous expression in testis (RPKM 3.6), thyroid (RPKM 3.3) and 25 other tissues.

Summary

Predicted to enable Nuclease activity. Predicted to be involved in nucleic acid phosphodiester bond hydrolysis. [provided by Alliance of Genome Resources, Apr 2022]

ASTE1 Products(2)

mRNA	Protein	Name
NM_001288950.2	NP_001275879.1	protein asteroid homolog 1 isoform 1
NM_014065.4	NP_054784.2	protein asteroid homolog 1 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables 3' overhang single-stranded DNA endodeoxyribonuclease activity	IDA IDA: Inferred from direct assay	34354233	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables single-stranded DNA endodeoxyribonuclease activity	IDA IDA: Inferred from direct assay	34354233	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in double-strand break repair via homologous recombination	IMP IMP: Inferred from mutant phenotype	34354233	GOA
involved in double-strand break repair via nonhomologous end joining	IMP IMP: Inferred from mutant phenotype	34354233	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ASTE1 Protein Structure

XPG_N

XPG_I_2

0
200
400
600
679 a.a.

Protein Preferred Names

Protein Names

protein asteroid homolog 1

Related Diseases

Diseases

Alias

Osgood-Schlatter'S Disease

Osgood-Schlatter Disease	Juvenile Osteochondrosis Of Tibial Tubercle
Osteochondrosis	Osteochondritis Of Tibial Tubercle
Osteochondrosis Of Proximal Tibia	Aseptic Necrosis Of The Tibial Tubercle
Osteochondrosis Of The Tibial Tubercle	Osteochondritis Juvenilis

Lynch Syndrome

Hereditary Nonpolyposis Colon Cancer	Hereditary Nonpolyposis Colorectal Cancer
Hereditary Nonpolyposis Colorectal Carcinoma	Hereditary Nonpolyposis Colorectal Neoplasms
Familial Nonpolyposis Colon Cancer	Hnpcc
Coca 1	Hereditary Defective Mismatch Repair Syndrome
Hereditary Non-Polyposis Colon Cancer	Hereditary Non-Polyposis Colon Cancer Syndrome
Hereditary Non-Polyposis Colorectal Cancer	Hereditary Non-Polyposis Colorectal Cancer Syndrome
Hereditary Nonpolyposis Colon Cancer Syndrome	Hereditary Nonpolyposis Colorectal Cancer Syndrome
Hereditary Nonpolyposis Colorectal Neoplasm	Hnpcc - Hereditary Nonpolyposis Colon Cancer
Cancer Family Syndrome	Familial Nonpolyposis Colorectal Cancer
Colon Cancer, Familial Nonpolyposis	Colorectal Neoplasms, Hereditary Nonpolyposis
Cancer, Colorectal, Nonpolyposis, Hereditary	Colorectal Cancer, Hereditary Nonpolyposis, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01110	ASTE1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ASTE1	RGD	RGD:1304643
Canis familiaris	ASTE1	VGNC	VGNC:52864
Felis catus	ASTE1	VGNC	VGNC:59981
Mus musculus	ASTE1	MGD	MGI:1913845
Bos taurus	ASTE1	VGNC	VGNC:26225
Macaca mulatta	ASTE1	VGNC	VGNC:84874

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