KLF15 - KLF transcription factor 15 Gene

Homo sapiens

Also known as KKLF

Gene ID: 28999 | Gene type: protein coding

About KLF15

Cytogenetic location: 3q21.3 Genomic coordinates (GRCh38): 3:126,288,125-126,357,408 (from NCBI)

This gene has 2 transcripts (splice variants), 251 orthologues and 22 paralogues. Broad expression in fat (RPKM 10.7), ovary (RPKM 8.2) and 17 other tissues.

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of peptidyl-lysine acetylation and positive regulation of transcription by RNA polymerase II. Located in nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]

KLF15 Products(1)

mRNA	Protein	Name
NM_014079.4	NP_054798.1	Krueppel-like factor 15

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	19767294	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	19767294	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	19767294	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23999430	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of peptidyl-lysine acetylation	IMP IMP: Inferred from mutant phenotype	20375365	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19767294	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	17438289	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLF15 Protein Structure

zf-H2C2_2

0
100
200
300
416 a.a.

Protein Preferred Names

Protein Names

Krueppel-like factor 15

Kruppel like factor 15

KLF15 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KLF15	Q9UIH9	PRKAB2	Homo sapiens	O43741	Validated Y2H	25416956
Intra	KLF15	Q9UIH9	GTF3C3	Homo sapiens	Q9Y5Q9	Validated Y2H	32814053
Intra	KLF15	Q9UIH9	GTF3C3	Homo sapiens	Q9Y5Q9	Y2H Array	32814053
Intra	KLF15	Q9UIH9	GTF3C3	Homo sapiens	Q9Y5Q9	Y2H Pooling	32814053
Intra	KLF15	Q9UIH9	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	KLF15	Q9UIH9	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	KLF15	Q9UIH9	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	KLF15	Q9UIH9	ZNF330	Homo sapiens	Q9Y3S2	Validated Y2H	32296183
Intra	KLF15	Q9UIH9	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	KLF15	Q9UIH9	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	KLF15	Q9UIH9	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	KLF15	Q9UIH9	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	KLF15	Q9UIH9	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	KLF15	Q9UIH9	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	KLF15	Q9UIH9	ZBTB24	Homo sapiens	O43167	Validated Y2H	25416956
Intra	KLF15	Q9UIH9	ZBTB24	Homo sapiens	O43167	Y2H Array	25416956
Intra	KLF15	Q9UIH9	ZBTB24	Homo sapiens	O43167	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Aortic Aneurysm

Aortic Rupture	Thoracoabdominal Aortic Aneurysm, Ruptured
Ruptured Aortic Aneurysm	Aortic Aneurysms
Aortic Aneurysm Without Mention Of Rupture Nos	Ruptured Abdominal Aortic Aneurysm
Aortic Aneurysm, Ruptured	Ruptured Thoracic Aortic Aneurysm

Glomerular Disease

Muscular Atrophy

Muscle Wasting	Amyotrophia
Wasting - Muscle	Skeletal Muscle Atrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07336	KLF15 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	KLF15	VGNC	VGNC:42434
Rattus norvegicus	KLF15	RGD	RGD:70918
Bos taurus	KLF15	VGNC	VGNC:30629
Felis catus	KLF15	VGNC	VGNC:63132
Mus musculus	KLF15	MGD	MGI:1929988
Macaca mulatta	KLF15	VGNC	VGNC:73829

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