CNIH4 - cornichon family AMPA receptor auxiliary protein 4 Gene

Homo sapiens

Also known as CNIH2; CNIH-4; HSPC163

Gene ID: 29097 | Gene type: protein coding

About CNIH4

Cytogenetic location: 1q42.11 Genomic coordinates (GRCh38): 1:224,356,803-224,379,452 (from NCBI)

This gene has 8 transcripts (splice variants), 212 orthologues and 4 paralogues. Ubiquitous expression in placenta (RPKM 7.6), colon (RPKM 7.3) and 25 other tissues.

Summary

Enables CCR5 Chemokine Receptor binding activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in endoplasmic reticulum and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Apr 2022]

CNIH4 Products(5)

mRNA	Protein	Name
NM_001277197.2	NP_001264126.1	protein cornichon homolog 4 isoform 2
NM_001277198.2	NP_001264127.1	protein cornichon homolog 4 isoform 3
NM_001277199.2	NP_001264128.1	protein cornichon homolog 4 isoform 4
NM_001277200.2	NP_001264129.1	protein cornichon homolog 4 isoform 5
NM_014184.4	NP_054903.1	protein cornichon homolog 4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables CCR5 chemokine receptor binding	IPI IPI: Inferred from physical interaction	24405750	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24405750	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	24405750	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	24405750	GOA
located in endoplasmic reticulum-Golgi intermediate compartment	IDA IDA: Inferred from direct assay	24405750	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CNIH4 Protein Structure

Cornichon

0
100
139 a.a.

Protein Preferred Names

Protein Names

protein cornichon homolog 4

cornichon homolog 4

Related Diseases

Diseases

Alias

Mitochondrial Complex Ii Deficiency

Isolated Mitochondrial Respiratory Chain Complex Ii Deficiency	Isolated Succinate-Coenzyme Q Reductase Deficiency
Isolated Succinate-Coq Reductase Deficiency	Isolated Succinate-Ubiquinone Reductase Deficiency
Mitochondrial Respiratory Chain Complex Ii Deficiency	Complex 2 Mitochondrial Respiratory Chain Deficiency
Succinate Coq Reductase Deficiency	Succinate Dehydrogenase Deficiency
Isolated Succinate Dehydrogenase Deficiency	Succinate-Coenzyme Q Reductase Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02887	CNIH4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CNIH4	RGD	RGD:1559740
Canis familiaris	CNIH4	VGNC	VGNC:39402
Felis catus	CNIH4	VGNC	VGNC:107861
Bos taurus	CNIH4	VGNC	VGNC:27504
Mus musculus	CNIH4	MGD	MGI:1925828
Macaca mulatta	CNIH4	VGNC	VGNC:71342

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