Mstn - myostatin Gene

Rattus norvegicus

Also known as Gdf8

Gene ID: 29152 | Gene type: protein coding

About Mstn

Summary

This gene encodes a member of the TGF-beta (transforming growth factor-beta) family of proteins. The encoded preproprotein is proteolytically processed to generate an N-terminal propeptide and a C-terminal subunit. The C-terminal subunits form the mature homodimer, which negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and Other mammals. [provided by RefSeq, Jun 2016]

Mstn Products(1)

mRNA	Protein	Name
NM_019151.2	NP_062024.1	growth/differentiation factor 8 precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	30765322	RGD
involved in negative regulation of muscle hypertrophy	IMP IMP: Inferred from mutant phenotype	16810717	RGD
involved in negative regulation of skeletal muscle tissue growth	IMP IMP: Inferred from mutant phenotype	16575154	RGD
involved in ovulation cycle process	IEP IEP: Inferred from expression pattern	18845635	RGD
involved in response to electrical stimulus	IEP IEP: Inferred from expression pattern	18787495	RGD
involved in response to estrogen	IEP IEP: Inferred from expression pattern	18845635	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	14749210	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	16919545	RGD
involved in response to gravity	IEP IEP: Inferred from expression pattern	11115768	RGD
involved in response to muscle activity	IEP IEP: Inferred from expression pattern	15743390	RGD
involved in response to testosterone	IEP IEP: Inferred from expression pattern	18841527	RGD
involved in skeletal muscle atrophy	IEP IEP: Inferred from expression pattern	15758361	RGD
involved in skeletal muscle tissue regeneration	IEP IEP: Inferred from expression pattern	11206133	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	16575154	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

growth/differentiation factor 8

GDF-8

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect Pre-designed Sets	Purity	Rare Diseases Unkown
HY-RS08731	MSTN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect Inhibitor	Purity	Rare Diseases Unkown
HY-P990733	Cibotercept	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mstn	NCBI	NCBI:2660
Felis catus	Mstn	NCBI	NCBI:101081322
Mus musculus	Mstn	NCBI	NCBI:17700

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