2. Gene
  3. Mstn - myostatin Gene

Mstn - myostatin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Gdf8

Gene ID: 29152 | Gene type: protein coding

About Mstn

Summary

This gene encodes a member of the TGF-beta (transforming growth factor-beta) family of proteins. The encoded preproprotein is proteolytically processed to generate an N-terminal propeptide and a C-terminal subunit. The C-terminal subunits form the mature homodimer, which negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and Other mammals. [provided by RefSeq, Jun 2016]

Mstn Products(1)

mRNA Protein Name
NM_019151.2 NP_062024.1 growth/differentiation factor 8 precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
30765322 RGD
involved in negative regulation of muscle hypertrophy IMP
IMP: Inferred from mutant phenotype
16810717 RGD
involved in negative regulation of skeletal muscle tissue growth IMP
IMP: Inferred from mutant phenotype
16575154 RGD
involved in ovulation cycle process IEP
IEP: Inferred from expression pattern
18845635 RGD
involved in response to electrical stimulus IEP
IEP: Inferred from expression pattern
18787495 RGD
involved in response to estrogen IEP
IEP: Inferred from expression pattern
18845635 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
14749210 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
16919545 RGD
involved in response to gravity IEP
IEP: Inferred from expression pattern
11115768 RGD
involved in response to muscle activity IEP
IEP: Inferred from expression pattern
15743390 RGD
involved in response to testosterone IEP
IEP: Inferred from expression pattern
18841527 RGD
involved in skeletal muscle atrophy IEP
IEP: Inferred from expression pattern
15758361 RGD
involved in skeletal muscle tissue regeneration IEP
IEP: Inferred from expression pattern
11206133 RGD
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
16575154 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

growth/differentiation factor 8

GDF-8

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08731 MSTN Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18142 Mstn Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990733 Cibotercept Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mstn NCBI NCBI:2660
Felis catus Mstn NCBI NCBI:101081322
Mus musculus Mstn NCBI NCBI:17700