Mstn - myostatin Gene

Mus musculus

Also known as Cmpt; Gdf8

Gene ID: 17700 | Gene type: protein coding

About Mstn

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Homozygous knockout mice for this gene exhibit increased muscle mass and bone density, and reduced adiposity. [provided by RefSeq, Jul 2016]

Mstn Products(1)

mRNA	Protein	Name
NM_010834.3	NP_034964.1	growth/differentiation factor 8 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables heparin binding	IDA IDA: Inferred from direct assay	19644449	MGI
enables identical protein binding	IDA IDA: Inferred from direct assay	28257634	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12595574	MGI
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	19644449	MGI
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	11459935	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular response to dexamethasone stimulus	IDA IDA: Inferred from direct assay	23752591	MGI
involved in myoblast migration involved in skeletal muscle regeneration	IMP IMP: Inferred from mutant phenotype	19406121	MGI
involved in negative regulation of insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16182246	MGI
involved in negative regulation of kinase activity	IMP IMP: Inferred from mutant phenotype	19357233	MGI
acts upstream of or within negative regulation of skeletal muscle tissue growth	IMP IMP: Inferred from mutant phenotype	18286185	MGI
involved in negative regulation of skeletal muscle tissue growth	IMP IMP: Inferred from mutant phenotype	9139826	MGI
involved in positive regulation of lamellipodium assembly	IMP IMP: Inferred from mutant phenotype	19406121	MGI
involved in positive regulation of macrophage chemotaxis	IMP IMP: Inferred from mutant phenotype	19406121	MGI
involved in skeletal muscle satellite cell differentiation	IMP IMP: Inferred from mutant phenotype	26923583	MGI
involved in skeletal muscle tissue regeneration	IMP IMP: Inferred from mutant phenotype	26923583	MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	12595574	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	12595574	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

growth/differentiation factor 8

Recombinant Mstn Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74127	GDF-8 Protein, Human/Mouse/Rat (HEK293, Fc)	O08689 (D268-S376)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08731	MSTN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mstn	NCBI	NCBI:2660
Felis catus	Mstn	NCBI	NCBI:101081322
Rattus norvegicus	Mstn	NCBI	NCBI:29152

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