Fdx1 - ferredoxin 1 Gene

Rattus norvegicus

Gene ID: 29189 | Gene type: protein coding

About Fdx1

Summary

Enables electron transfer activity; Enzyme binding activity; and iron ion binding activity. Contributes to NADPH-adrenodoxin reductase activity and Cholesterol monooxygenase (side-chain-cleaving) activity. Involved in several processes, including NADPH oxidation; cellular response to epinephrine stimulus; and cellular response to Leptin stimulus. Located in mitochondrial crista and mitochondrial matrix. Biomarker of pancreatitis. Orthologous to human FDX1 (ferredoxin 1). [provided by Alliance of Genome Resources, Apr 2022]

Fdx1 Products(1)

mRNA	Protein	Name
NM_017126.2	NP_058822.2	adrenodoxin, mitochondrial precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to NADPH-adrenodoxin reductase activity	IDA IDA: Inferred from direct assay	8789462	RGD
contributes to cholesterol monooxygenase (side-chain-cleaving) activity	IDA IDA: Inferred from direct assay	8789462	RGD
enables electron transfer activity	IDA IDA: Inferred from direct assay	8789462	RGD
enables enzyme binding	IPI IPI: Inferred from physical interaction	10525147	RGD
enables iron ion binding	IDA IDA: Inferred from direct assay	8789462	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in NADPH oxidation	IDA IDA: Inferred from direct assay	10525147	RGD
involved in adrenal gland development	IEP IEP: Inferred from expression pattern	8097866	RGD
involved in cellular response to epinephrine stimulus	IEP IEP: Inferred from expression pattern	11064152	RGD
involved in cellular response to leptin stimulus	IEP IEP: Inferred from expression pattern	10098510	RGD
involved in cellular response to organic cyclic compound	IEP IEP: Inferred from expression pattern	11064152	RGD
involved in positive regulation of oxidoreductase activity	IMP IMP: Inferred from mutant phenotype	11325963	RGD
involved in regulation of catalytic activity	IDA IDA: Inferred from direct assay	8789462	RGD
involved in response to gonadotropin	IEP IEP: Inferred from expression pattern	16139340	RGD
involved in response to leptin	IEP IEP: Inferred from expression pattern	11604238	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial crista	IDA IDA: Inferred from direct assay	16139340	RGD
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	2170421	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

adrenodoxin, mitochondrial

adrenal ferredoxin

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12040	Elesclomol		99.80%	Phase 3

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16223	Fdx1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04854	FDX1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fdx1	NCBI	NCBI:2230

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