Snca - synuclein alpha Gene

Rattus norvegicus

Gene ID: 29219 | Gene type: protein coding

About Snca

Primary_assembly 4: 89,696,420-89,796,262 reverse strand.mRatBN7.2:CM026977.1

This gene has 4 transcripts (splice variants), 189 orthologues, 2 paralogues and is associated with 35 phenotypes. Biased expression in Brain (RPKM 542.3), Spleen (RPKM 92.9) and 1 other tissue.

Summary

Enables several functions, including Phospholipase binding activity; protein N-terminus binding activity; and tubulin binding activity. Involved in several processes, including behavioral response to cocaine; negative regulation of nitrogen compound metabolic process; and response to desipramine. Located in several cellular components, including cytoplasmic vesicle; distal axon; and mitochondrion. Used to study Parkinson's disease and amphetamine abuse. Biomarker of mental depression and neurilemmoma. Human ortholog(s) of this gene implicated in Alzheimer's disease; Lewy body dementia; Parkinson's disease; Parkinson's disease 1; and Parkinson's disease 4. Orthologous to human SNCA (synuclein alpha). [provided by Alliance of Genome Resources, Apr 2022]

Snca Products(1)

mRNA	Protein	Name
NM_019169.3	NP_062042.1	alpha-synuclein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables beta-tubulin binding	IDA IDA: Inferred from direct assay	18800064	RGD
enables enzyme binding	IPI IPI: Inferred from physical interaction	11943812	RGD
enables microtubule binding	IDA IDA: Inferred from direct assay	11698390	RGD
enables phospholipase binding	IPI IPI: Inferred from physical interaction	11821392	RGD
enables phospholipid binding	IDA IDA: Inferred from direct assay	11679584	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11032911	RGD
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	11821392	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in behavioral response to cocaine	IMP IMP: Inferred from mutant phenotype	18001274	RGD
involved in cellular response to fibroblast growth factor stimulus	IEP IEP: Inferred from expression pattern	12562524	RGD
involved in negative regulation of dopamine metabolic process	IMP IMP: Inferred from mutant phenotype	11943812	RGD
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	17635667	RGD
involved in negative regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	11943812	RGD
involved in response to cocaine	IEP IEP: Inferred from expression pattern	14622225	RGD
involved in response to desipramine	IEP IEP: Inferred from expression pattern	19818834	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon terminus	IDA IDA: Inferred from direct assay	12127102	RGD
located in cytoplasmic vesicle membrane	IDA IDA: Inferred from direct assay	11943812	RGD
located in growth cone	IDA IDA: Inferred from direct assay	12821390	RGD
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	19429081	RGD
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	19429081	RGD
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	19429081	RGD
located in mitochondrion	IDA IDA: Inferred from direct assay	11943812	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	17275196	RGD
located in nuclear outer membrane	IDA IDA: Inferred from direct assay	11810180	RGD
located in presynapse	IDA IDA: Inferred from direct assay	12000718	RGD
located in ribosome	IDA IDA: Inferred from direct assay	11810180	RGD
located in synaptic vesicle	IDA IDA: Inferred from direct assay	18001274	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	10777786	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Snca Protein Structure

Synuclein

0
100
149 a.a.

Protein Preferred Names

Protein Names

alpha-synuclein

synuclein, alpha (non A4 component of amyloid precursor)

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-135902A	Synucleozid hydrochloride	Inhibitor	98.23%	Unkown
HY-135902	Synucleozid	Inhibitor	/	Unkown
HY-RS13482	SNCA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13483	Snca Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13484	Snca Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990898	Amlenetug		/	Unkown
HY-P990922	Indenebart		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Snca	NCBI	NCBI:6622
Mus musculus	Snca	NCBI	NCBI:20617

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