Tjp1 - tight junction protein 1 Gene

Rattus norvegicus

Also known as ZO-1

Gene ID: 292994 | Gene type: protein coding

About Tjp1

Summary

Enables protein C-terminus binding activity. Involved in several processes, including cellular response to glucose stimulus; negative regulation of vascular permeability; and response to lipopolysaccharide. Located in bicellular tight junction; cytoplasm; and gap junction. Biomarker of several diseases, including brain ischemia; cholestasis; peptic esophagitis; perinatal necrotizing enterocolitis; and uveitis. Orthologous to human TJP1 (tight junction protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Tjp1 Products(1)

mRNA	Protein	Name
NM_001106266.1	NP_001099736.1	tight junction protein ZO-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	12960056	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16617054	RGD
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	15980428	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	16567508	RGD
involved in negative regulation of vascular permeability	IEP IEP: Inferred from expression pattern	20137299	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	17515855	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	17515855	RGD
involved in response to magnetism	IEP IEP: Inferred from expression pattern	20137299	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	18360096	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in bicellular tight junction	IDA IDA: Inferred from direct assay	17899156	RGD
located in cell-cell junction	IDA IDA: Inferred from direct assay	25486565	RGD
located in gap junction	IDA IDA: Inferred from direct assay	29021339	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

tight junction protein ZO-1

zona occludens 1	zona occludens protein 1
zonula occludens protein 1

Tjp1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Tjp1	F1M4A0	Ocln	Rattus norvegicus	Q6P6T5	Anti Bait CoIP	22106313

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14553	TJP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tjp1	NCBI	NCBI:7082

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