Ocln - occludin Gene

Rattus norvegicus

Gene ID: 83497 | Gene type: protein coding

About Ocln

Summary

Predicted to enable protein domain specific binding activity. Involved in cellular response to tumor necrosis factor and response to interleukin-18. Located in apical plasma membrane and lateral plasma membrane. Biomarker of diabetic retinopathy. Human ortholog(s) of this gene implicated in Crohn's disease and pseudo-TORCH syndrome 1. Orthologous to human OCLN (occludin). [provided by Alliance of Genome Resources, Apr 2022]

Ocln Products(1)

mRNA	Protein	Name
NM_031329.3	NP_112619.2	occludin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19470647	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	21748286	RGD
involved in response to Gram-positive bacterium	IEP IEP: Inferred from expression pattern	20501441	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	31116255	RGD
involved in response to interleukin-18	IMP IMP: Inferred from mutant phenotype	22001439	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	22001439	RGD
located in lateral plasma membrane	IDA IDA: Inferred from direct assay	22001439	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

occludin

Ocln Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Ocln	Q6P6T5	Tjp1	Rattus norvegicus	F1M4A0	Anti Bait CoIP	19470647
Intra	Ocln	Q6P6T5	Ptk2	Rattus norvegicus	O35346	Anti Bait CoIP	19470647
Intra	Ocln	Q6P6T5	Ptk2	Rattus norvegicus	O35346	Anti Bait CoIP	22106313

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09743	OCLN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ocln	NCBI	NCBI:100506658

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