Mc3r - melanocortin 3 receptor Gene

Rattus norvegicus

Gene ID: 29310 | Gene type: protein coding

About Mc3r

Primary_assembly 3: 161,016,347-161,017,444 forward strand.mRatBN7.2:CM026976.1

This gene has 1 transcript (splice variant), 141 orthologues, 18 paralogues and is associated with 2 phenotypes.

Summary

Enables Melanocortin Receptor activity and peptide hormone binding activity. Involved in several processes, including adenylate cyclase-modulating G protein-coupled receptor signaling pathway; homoiothermy; and sodium ion homeostasis. Predicted to be integral component of plasma membrane. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in obesity. Orthologous to human MC3R (melanocortin 3 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Mc3r Products(1)

mRNA	Protein	Name
NM_001025270.4	NP_001020441.3	melanocortin receptor 3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables melanocortin receptor activity	IDA IDA: Inferred from direct assay	17023527	RGD
enables melanocortin receptor activity	IMP IMP: Inferred from mutant phenotype	17023527	RGD
enables peptide hormone binding	IDA IDA: Inferred from direct assay	17023527	RGD
enables peptide hormone binding	IMP IMP: Inferred from mutant phenotype	17023527	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	15985309	RGD
involved in homoiothermy	IMP IMP: Inferred from mutant phenotype	21091037	RGD
involved in regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	21091037	RGD
involved in regulation of heart rate	IMP IMP: Inferred from mutant phenotype	21091037	RGD
involved in sodium ion homeostasis	IEP IEP: Inferred from expression pattern	19570553	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mc3r Protein Structure

7tmA_MC3R

0
100
200
300
323 a.a.

Protein Preferred Names

Protein Names

melanocortin receptor 3

MC3-R

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18678A	Bremelanotide Acetate	Agonist	99.98%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-147301	Resomelagon	Agonist	99.63%	Phase 2

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P0227	SHU 9119		99.95%	Unkown
HY-P0097A	Nonapeptide-1 acetate salt	Antagonist	98.70%	Unkown
HY-P1214	γ1-MSH	Agonist	99.71%	Unkown
HY-P1217	[D-Trp8]-γ-MSH	Agonist	99.57%	Unkown
HY-P1531	γ-1-Melanocyte Stimulating Hormone (MSH), amide	Agonist	99.32%	Unkown
HY-P1209A	PG106 TFA	Antagonist	99.61%	Unkown
HY-P0097	Nonapeptide-1	Antagonist	99.04%	Unkown
HY-P1217A	[D-Trp8]-γ-MSH TFA	Agonist	/	Unkown
HY-P1214A	γ1-MSH TFA	Agonist	/	Unkown
HY-P0252B	α-MSH free acid	Agonist	/	Unkown
HY-168383	(E/Z)-Resomelagon acetate	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mc3r	NCBI	NCBI:4159

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