Adora2b - adenosine A2B receptor Gene

Rattus norvegicus

Gene ID: 29316 | Gene type: protein coding

About Adora2b

Primary_assembly 10: 46,940,384-46,956,772 forward strand.mRatBN7.2:CM026983.1

This gene has 1 transcript (splice variant), 200 orthologues, 3 paralogues and is associated with 9 phenotypes. Biased expression in Lung (RPKM 18.9), Brain (RPKM 17.7) and 9 other tissues.

Summary

Predicted to enable G protein-coupled receptor activity. Involved in several processes, including negative regulation of collagen biosynthetic process; positive regulation of cAMP-mediated signaling; and positive regulation of interleukin-6 production. Located in cell surface and plasma membrane. Orthologous to human ADORA2B (adenosine A2b receptor). [provided by Alliance of Genome Resources, Apr 2022]

Adora2b Products(1)

mRNA	Protein	Name
NM_017161.2	NP_058857.2	adenosine receptor A2b

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	11230362	RGD
involved in negative regulation of collagen biosynthetic process	IMP IMP: Inferred from mutant phenotype	9535419	RGD
involved in positive regulation of cAMP/PKA signal transduction	IMP IMP: Inferred from mutant phenotype	8012696	RGD
involved in positive regulation of catecholamine secretion	IMP IMP: Inferred from mutant phenotype	18823369	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	12021208	RGD
involved in positive regulation of endothelial cell migration	IMP IMP: Inferred from mutant phenotype	11882603	RGD
involved in positive regulation of endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	11882603	RGD
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	26385692	RGD
involved in positive regulation of norepinephrine secretion	IMP IMP: Inferred from mutant phenotype	15223300	RGD
involved in positive regulation of steroid biosynthetic process	IMP IMP: Inferred from mutant phenotype	18582595	RGD
involved in regulation of glucose metabolic process	IMP IMP: Inferred from mutant phenotype	26385692	RGD
involved in response to angiotensin	IMP IMP: Inferred from mutant phenotype	26385692	RGD
involved in vasodilation	IDA IDA: Inferred from direct assay	10666062	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	12021208	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Adora2b Protein Structure

7tm_GPCRs

0
100
200
300
332 a.a.

Protein Preferred Names

Protein Names

adenosine receptor A2b

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00397	ADORA2B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00398	Adora2b Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00399	Adora2b Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adora2b	NCBI	NCBI:136

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