GSTA1 - glutathione S-transferase alpha 1 Gene

Homo sapiens

Also known as GST2; GTH1; GSTA1-1; GST-epsilon

Gene ID: 2938 | Gene type: protein coding

About GSTA1

Cytogenetic location: 6p12.2 Genomic coordinates (GRCh38): 6:52,791,371-52,803,816 (from NCBI)

This gene has 3 transcripts (splice variants), 129 orthologues and 11 paralogues. Biased expression in liver (RPKM 342.4), kidney (RPKM 288.3) and 6 other tissues.

Summary

This gene encodes a member of a family of Enzymes that function to add glutathione to target electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. This action is an important step in detoxification of these compounds. This subfamily of Enzymes has a particular role in protecting cells from Reactive Oxygen Species and the products of peroxidation. Polymorphisms in this gene influence the ability of individuals to metabolize different drugs. This gene is located in a cluster of similar genes and pseudogenes on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GSTA1 Products(2)

mRNA	Protein	Name
NM_001319059.2	NP_001305988.1	glutathione S-transferase A1 isoform 2
NM_145740.5	NP_665683.1	glutathione S-transferase A1 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables fatty acid binding	IPI IPI: Inferred from physical interaction	16624487	GOA
enables glutathione peroxidase activity	IDA IDA: Inferred from direct assay	16624487	GOA
enables glutathione transferase activity	IDA IDA: Inferred from direct assay	9084911	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA
enables steroid delta-isomerase activity	IDA IDA: Inferred from direct assay	11152686	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in epithelial cell differentiation	IEP IEP: Inferred from expression pattern	21492153	GOA
involved in glutathione derivative biosynthetic process	IDA IDA: Inferred from direct assay	9084911	GOA
acts upstream of or within glutathione metabolic process	IDA IDA: Inferred from direct assay	11851347	GOA
involved in glutathione metabolic process	IDA IDA: Inferred from direct assay	20606271	GOA
involved in linoleic acid metabolic process	IDA IDA: Inferred from direct assay	16624487	GOA
involved in prostaglandin metabolic process	IDA IDA: Inferred from direct assay	9084911	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GSTA1 Protein Structure

GST_N

GST_C

0
100
200
222 a.a.

Protein Preferred Names

Protein Names

glutathione S-transferase A1

13-hydroperoxyoctadecadienoate peroxidase

Recombinant GSTA1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75153	GSTA1 Protein, Human (HEK293, His, solution)	P08263 (M1-F222)	≥95%

Related Diseases

Diseases

Alias

Ovarian Endodermal Sinus Tumor

Endodermal Sinus Tumor Of Ovary	Ovarian Yolk Sac Tumor
Endodermal Sinus Tumour Of Ovary	Ovarian Endodermal Sinus Tumour
Ovarian Yolk Sac Tumour

Ovarian Primitive Germ Cell Tumor

Hemorrhagic Cystitis

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N1963	Curzerene		98.00%	Unkown
HY-RS16237	Gsta1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-N14116	Garlic oil	Inducer	/	Unkown
HY-RS05872	GSTA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GSTA1	RGD	RGD:2753
Others	GSTA1	NCBI

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