Rab7a - RAB7A, member RAS oncogene family Gene

Rattus norvegicus

Also known as Rab7

Gene ID: 29448 | Gene type: protein coding

About Rab7a

Summary

Enables GDP binding activity; GTP binding activity; and small GTPase binding activity. Involved in bone resorption. Located in alveolar lamellar body and late endosome. Is anchored component of synaptic vesicle membrane. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2B. Orthologous to human RAB7A (RAB7A, member Ras oncogene family). [provided by Alliance of Genome Resources, Apr 2022]

Rab7a Products(1)

mRNA	Protein	Name
NM_023950.4	NP_076440.1	ras-related protein Rab-7a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GDP binding	IDA IDA: Inferred from direct assay	16040606	RGD
enables GTP binding	IDA IDA: Inferred from direct assay	16040606	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15186776	RGD
enables small GTPase binding	IPI IPI: Inferred from physical interaction	16040606	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in bone resorption	IMP IMP: Inferred from mutant phenotype	11514537	RGD
involved in synaptic vesicle recycling via endosome	EXP EXP: Inferred from Experiment	29950309	RGD
involved in synaptic vesicle recycling via endosome	IDA IDA: Inferred from direct assay	29950309	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in alveolar lamellar body	IDA IDA: Inferred from direct assay	7868367	RGD
located in late endosome	IDA IDA: Inferred from direct assay	19337031	RGD
is active in presynaptic endosome	IDA IDA: Inferred from direct assay	29950309	RGD
is active in presynaptic endosome	IMP IMP: Inferred from mutant phenotype	31074746	RGD
is active in synaptic vesicle membrane	EXP EXP: Inferred from Experiment	20926670	RGD
is active in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	20926670	RGD
is active in synaptic vesicle membrane	IMP IMP: Inferred from mutant phenotype	20926670	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ras-related protein Rab-7a

RAB7, member RAS oncogene family	ras-related protein BRL-RAS
ras-related protein p23

Recombinant Rab7a Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75998	RAB7A Protein, Rat (His)	P09527 (M1-C207)	≥95%

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-N0484	Liensinine		99.97%	Phase 2

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11576	RAB7A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rab7a	NCBI	NCBI:7879

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