2. Gene
  3. GSTM2 - glutathione S-transferase mu 2 Gene

GSTM2 - glutathione S-transferase mu 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GST4; GSTM; GTHMUS; GSTM2-2

Gene ID: 2946 | Gene type: protein coding

About GSTM2

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:109,668,057-109,683,997 (from NCBI)

This gene has 15 transcripts (splice variants), 144 orthologues and 11 paralogues. Ubiquitous expression in ovary (RPKM 68.7), skin (RPKM 43.2) and 25 other tissues.

Summary

Cytosolic and membrane-bound forms of Glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a Glutathione S-transferase that belongs to the mu class. The mu class of Enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of Enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. [provided by RefSeq, Jul 2008]

GSTM2 Products(2)

mRNA Protein Name
NM_000848.4 NP_000839.1 glutathione S-transferase Mu 2 isoform 1
NM_001142368.2 NP_001135840.1 glutathione S-transferase Mu 2 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
8373352 GOA
enables fatty acid binding IPI
IPI: Inferred from physical interaction
16624487 GOA
enables glutathione binding IDA
IDA: Inferred from direct assay
2034681 GOA
enables glutathione peroxidase activity IDA
IDA: Inferred from direct assay
16624487 GOA
enables glutathione transferase activity IDA
IDA: Inferred from direct assay
2034681 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
24965446 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
8373352 GOA
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
22406107 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cellular detoxification of nitrogen compound IDA
IDA: Inferred from direct assay
2034681 GOA
involved in cellular response to caffeine IDA
IDA: Inferred from direct assay
22406107 GOA
involved in glutathione metabolic process IDA
IDA: Inferred from direct assay
2034681 GOA
involved in hepoxilin biosynthetic process IDA
IDA: Inferred from direct assay
21046276 GOA
involved in linoleic acid metabolic process IDA
IDA: Inferred from direct assay
16624487 GOA
involved in negative regulation of ryanodine-sensitive calcium-release channel activity IDA
IDA: Inferred from direct assay
17023043 GOA
involved in nitrobenzene metabolic process IDA
IDA: Inferred from direct assay
2034681 GOA
involved in positive regulation of ryanodine-sensitive calcium-release channel activity IDA
IDA: Inferred from direct assay
17023043 GOA
involved in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IDA
IDA: Inferred from direct assay
17023043 GOA
involved in xenobiotic catabolic process IDA
IDA: Inferred from direct assay
2034681 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
2034681 GOA
located in sarcoplasmic reticulum IDA
IDA: Inferred from direct assay
22406107 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GSTM2 Protein Structure

GST_N

GST_N: Glutathione S-transferase, N-terminal domain (3 - 82)

GST_C

GST_C: Glutathione S-transferase, C-terminal domain (104 - 189)

  • 0
  • 100
  • 200
  • 218 a.a.
Protein Preferred Names Protein Names

glutathione S-transferase Mu 2

GST class-mu 2

Recombinant GSTM2 Proteins

Cat. No. Product Name Accession Purity
HY-P75152 GSTM2 Protein, Human (His) P28161-1 (M1-K218) ≥95%

Related Diseases

Diseases Alias
Frontonasal Dysplasia 1

Frontorhiny

Frontonasal Dysplasia

Fnd

Frontonasal Malformation

Fnm

Median Facial Cleft Syndrome

Midline Facial Cleft

FND1

Median Cleft Face Syndrome

Median Cleft Syndrome

Frontonasal Dysplasia Sequence

Median Facial Cleft

Tessier Number 0-14 And 30 Facial Cleft

Alx3-Related Frontonasal Dysplasia

Frontonasal Dysplasia Type 1

Isolated Median Cleft Face Syndrome

Doid:0081044

Doid:0081045

Dysplasia, Frontonasal, Type
Barrett'S Adenocarcinoma

Barrett Adenocarcinoma

Adenocarcinoma Arising In Barrett'S Mucosa
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-A0122 Plicamycin Inhibitor 99.75% Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GSTM2 MGD MGI:1915562
Rattus norvegicus GSTM2 RGD RGD:2756