Slc1a2 - solute carrier family 1 member 2 Gene

Rattus norvegicus

Also known as Glt; Eaat2; Glt-1

Gene ID: 29482 | Gene type: protein coding

About Slc1a2

Primary_assembly 3: 89,005,129-89,126,498 forward strand.mRatBN7.2:CM026976.1

This gene has 7 transcripts (splice variants), 287 orthologues, 6 paralogues and is associated with 9 phenotypes. Restricted expression toward (RPKM 1451.5).

Summary

Enables high-affinity glutamate transmembrane transporter activity. Involved in L-glutamate transmembrane transport. Located in several cellular components, including astrocyte projection; dendrite; and presynaptic membrane. Is integral component of plasma membrane. Part of membrane protein complex. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 41. Orthologous to human SLC1A2 (solute carrier family 1 member 2). [provided by Alliance of Genome Resources, Apr 2022]

Slc1a2 Products(3)

mRNA	Protein	Name
NM_001035233.2	NP_001030310.2	excitatory amino acid transporter 2 isoform b
NM_001302089.2	NP_001289018.1	excitatory amino acid transporter 2 isoform c
NM_017215.3	NP_058911.2	excitatory amino acid transporter 2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables glutamate:sodium symporter activity	IDA IDA: Inferred from direct assay	1448170	RGD
enables high-affinity L-glutamate transmembrane transporter activity	IDA IDA: Inferred from direct assay	1448170	RGD
enables high-affinity L-glutamate transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	10899959	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in L-glutamate transmembrane transport	IMP IMP: Inferred from mutant phenotype	10899959	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in astrocyte projection	IDA IDA: Inferred from direct assay	9334410	RGD
located in cell body	IDA IDA: Inferred from direct assay	9334410	RGD
located in dendritic shaft	IDA IDA: Inferred from direct assay	11896154	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	11950769	RGD
part of membrane protein complex	IDA IDA: Inferred from direct assay	9334410	RGD
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	1448170	RGD
located in presynaptic membrane	IDA IDA: Inferred from direct assay	11896154	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Slc1a2 Protein Structure

SDF

0
100
200
300
400
500
573 a.a.

Protein Preferred Names

Protein Names

excitatory amino acid transporter 2

glial glutamate transporter GLT1/V3	glial glutamate transporter GLT1/V4
glutamate transporter 1	high affinity glucose transporter
sodium-dependent glutamatespartate transporter 2	solute carrier family 1 (glial high affinity glutamate transporter), member 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13051	SLC1A2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13052	Slc1a2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13053	Slc1a2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc1a2	NCBI	NCBI:6506

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