Scn10a - sodium voltage-gated channel alpha subunit 10 Gene

Rattus norvegicus

Also known as PN3; Nav1.8; Na(V)1.8

Gene ID: 29571 | Gene type: protein coding

About Scn10a

Primary_assembly 8: 119,350,724-119,462,614 reverse strand.mRatBN7.2:CM026981.1

This gene has 1 transcript (splice variant), 331 orthologues, 26 paralogues and is associated with 14 phenotypes. Biased expression in Heart (RPKM 8.7), Testes (RPKM 2.7) and 4 other tissues.

Summary

Enables voltage-gated Sodium Channel activity. Involved in odontogenesis of dentin-containing tooth; sensory perception of pain; and sodium ion transport. Located in axon. Is integral component of membrane. Part of clathrin complex. Is active in glutamatergic synapse. Is integral component of presynaptic membrane. Used to study sciatic neuropathy. Human ortholog(s) of this gene implicated in familial episodic pain syndrome 2. Orthologous to human SCN10A (sodium voltage-gated channel alpha subunit 10). [provided by Alliance of Genome Resources, Apr 2022]

Scn10a Products(1)

mRNA	Protein	Name
NM_017247.2	NP_058943.2	sodium channel protein type 10 subunit alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12050667	RGD
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IDA IDA: Inferred from direct assay	26187311	RGD
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IMP IMP: Inferred from mutant phenotype	26187311	RGD
enables voltage-gated sodium channel activity	IDA IDA: Inferred from direct assay	8538791	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in odontogenesis of dentin-containing tooth	IEP IEP: Inferred from expression pattern	21640979	RGD
involved in sodium ion transport	IDA IDA: Inferred from direct assay	8538791	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	21118538	RGD
part of clathrin complex	IDA IDA: Inferred from direct assay	15797711	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	19162133	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	19162133	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Scn10a Protein Structure

Ion_trans

Na_trans_cytopl

Ion_trans

Na_trans_assoc

Ion_trans

Na_channel_gate

Ion_trans

0
400
800
1200
1600
1956 a.a.

Protein Preferred Names

Protein Names

sodium channel protein type 10 subunit alpha

peripheral nerve sodium channel 3	sensory neuron sodium channel
sodium channel protein type X subunit alpha	sodium channel type X alpha polypeptide
sodium channel voltage-gated type X alpha polypeptide	sodium channel, voltage-gated, type 10, alpha polypeptide
sodium channel, voltage-gated, type X, alpha subunit	voltage-gated sodium channel subunit alpha Nav1.8

Scn10a Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Scn10a	Q62968	S100a10	Rattus norvegicus	P05943	Y2H	12050667
Intra	Scn10a	Q62968	Prx	Rattus norvegicus	Q63425	Y2H	12591166
Intra	Scn10a	Q62968	Dynlt1	Rattus norvegicus	Q9Z336	Anti Bait CoIP	12591166

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12519	SCN10A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12520	Scn10a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12521	Scn10a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Scn10a	NCBI	NCBI:6336

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