Tgfbr3 - transforming growth factor beta receptor 3 Gene

Rattus norvegicus

Also known as betaglycan

Gene ID: 29610 | Gene type: protein coding

About Tgfbr3

Primary_assembly 14: 2,489,397-2,663,341 forward strand.mRatBN7.2:CM026987.1

This gene has 1 transcript (splice variant), 203 orthologues, 2 paralogues and is associated with 5 phenotypes. Biased expression in Adrenal (RPKM 475.), Lung (RPKM 174.) and 9 other tissues.

Summary

Enables several functions, including activin binding activity; growth factor binding activity; and heparin binding activity. Involved in several processes, including animal organ regeneration; regulation of transforming growth factor beta receptor signaling pathway; and transforming growth factor beta receptor complex assembly. Located in cytoplasm; extracellular matrix; and extracellular space. Is integral component of plasma membrane. Part of receptor complex. Orthologous to human TGFBR3 (transforming growth factor beta receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Tgfbr3 Products(1)

mRNA	Protein	Name
NM_017256.1	NP_058952.1	transforming growth factor beta receptor type 3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables activin binding	IDA IDA: Inferred from direct assay	12385827	RGD
enables fibroblast growth factor binding	IDA IDA: Inferred from direct assay	1556106	RGD
enables heparin binding	IDA IDA: Inferred from direct assay	8106553	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	7852346	RGD
enables transforming growth factor beta binding	IDA IDA: Inferred from direct assay	1657407	RGD
contributes to transforming growth factor beta binding	IPI IPI: Inferred from physical interaction	7852346	RGD
enables transforming growth factor beta receptor activity, type III	IDA IDA: Inferred from direct assay	8106553	RGD
enables transforming growth factor beta receptor binding	IDA IDA: Inferred from direct assay	8106553	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in animal organ regeneration	IEP IEP: Inferred from expression pattern	9699514	RGD
involved in negative regulation of transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	10746731	RGD
involved in positive regulation of transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	8106553	RGD
involved in protein-containing complex assembly	IDA IDA: Inferred from direct assay	12385827	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	12183510	RGD
involved in transforming growth factor beta receptor complex assembly	IMP IMP: Inferred from mutant phenotype	8106553	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	2592419	RGD
located in membrane	IDA IDA: Inferred from direct assay	8106553	RGD
part of receptor complex	IDA IDA: Inferred from direct assay	7852346	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tgfbr3 Protein Structure

0
200
400
600
800
853 a.a.

Protein Preferred Names

Protein Names

transforming growth factor beta receptor type 3

TGF-beta receptor type 3	TGF-beta receptor type III
TGFR-3	transforming growth factor, beta receptor III

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14450	TGFBR3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14451	Tgfbr3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14452	Tgfbr3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14453	TGFBR3L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tgfbr3	NCBI	NCBI:7049
Mus musculus	Tgfbr3	NCBI	NCBI:21814

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