TGFBR3 - transforming growth factor beta receptor 3 Gene

Homo sapiens

Also known as BGCAN; betaglycan

Gene ID: 7049 | Gene type: protein coding

About TGFBR3

Cytogenetic location: 1p22.1 Genomic coordinates (GRCh38): 1:91,680,343-91,906,002 (from NCBI)

This gene has 11 transcripts (splice variants), 203 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in fat (RPKM 40.0), ovary (RPKM 37.4) and 23 other tissues.

Summary

This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta Receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010]

TGFBR3 Products(12)

mRNA	Protein	Name
XM_047429271.1	XP_047285227.1	transforming growth factor beta receptor type 3 isoform X2
XM_047429254.1	XP_047285210.1	transforming growth factor beta receptor type 3 isoform X1
NM_001195683.2	NP_001182612.1	transforming growth factor beta receptor type 3 isoform b precursor
XM_047429255.1	XP_047285211.1	transforming growth factor beta receptor type 3 isoform X1
NM_001195684.1	NP_001182613.1	transforming growth factor beta receptor type 3 isoform b precursor
NR_036634.2
XM_047429256.1	XP_047285212.1	transforming growth factor beta receptor type 3 isoform X2
XM_047429247.1	XP_047285203.1	transforming growth factor beta receptor type 3 isoform X1
XM_006710867.3	XP_006710930.1	transforming growth factor beta receptor type 3 isoform X1
XM_047429261.1	XP_047285217.1	transforming growth factor beta receptor type 3 isoform X2
XM_047429273.1	XP_047285229.1	transforming growth factor beta receptor type 3 isoform X3
NM_003243.5	NP_003234.2	transforming growth factor beta receptor type 3 isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables BMP binding	IPI IPI: Inferred from physical interaction	18184661	GOA
enables SMAD binding	IMP IMP: Inferred from mutant phenotype	11157754	GOA
enables coreceptor activity	IDA IDA: Inferred from direct assay	10746731	GOA
contributes to protein binding	IPI IPI: Inferred from physical interaction	10746731	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10746731	GOA
enables transforming growth factor beta binding	IDA IDA: Inferred from direct assay	11157754	GOA
contributes to transforming growth factor beta binding	IPI IPI: Inferred from physical interaction	11157754	GOA
enables transforming growth factor beta receptor activity	IDA IDA: Inferred from direct assay	12958365	GOA
enables transforming growth factor beta receptor activity, type III	IDA IDA: Inferred from direct assay	10746731	GOA
enables transmembrane signaling receptor activity	IDA IDA: Inferred from direct assay	18184661	GOA
enables type II transforming growth factor beta receptor binding	IDA IDA: Inferred from direct assay	11157754	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in BMP signaling pathway	IDA IDA: Inferred from direct assay	18184661	GOA
involved in cardiac epithelial to mesenchymal transition	IDA IDA: Inferred from direct assay	18184661	GOA
involved in epithelial to mesenchymal transition	IDA IDA: Inferred from direct assay	18184661	GOA
involved in immune response	IMP IMP: Inferred from mutant phenotype	16886151	GOA
involved in intracellular signal transduction	IMP IMP: Inferred from mutant phenotype	14557487	GOA
involved in negative regulation of SMAD protein signal transduction	IMP IMP: Inferred from mutant phenotype	30729664	GOA
involved in negative regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	29130787	GOA
involved in negative regulation of cell migration	IDA IDA: Inferred from direct assay	29130787	GOA
involved in negative regulation of extracellular matrix assembly	IMP IMP: Inferred from mutant phenotype	30729664	GOA
involved in positive regulation of SMAD protein signal transduction	IDA IDA: Inferred from direct assay	18184661	GOA
involved in positive regulation of SMAD protein signal transduction	IMP IMP: Inferred from mutant phenotype	11157754	GOA
involved in positive regulation of cell migration involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	30467960	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	30467960	GOA
involved in response to follicle-stimulating hormone	IDA IDA: Inferred from direct assay	14557487	GOA
involved in response to luteinizing hormone	IDA IDA: Inferred from direct assay	14557487	GOA
involved in response to prostaglandin E	IDA IDA: Inferred from direct assay	14557487	GOA
involved in transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	12958365	GOA
involved in transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	11157754	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	12958365	GOA
part of inhibin-betaglycan-ActRII complex	IDA IDA: Inferred from direct assay	10746731	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	11157754	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TGFBR3 Protein Structure

Zona_pellucida

0
200
400
600
800
851 a.a.

Protein Preferred Names

Protein Names

transforming growth factor beta receptor type 3

TGF-beta receptor type 3	TGF-beta receptor type III
TGFR-3	betaglycan proteoglycan
transforming growth factor beta receptor III

TGFBR3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TGFBR3	Q03167	GIPC1	Homo sapiens	O14908	Pull Down	11546783
Intra	TGFBR3	Q03167	GIPC1	Homo sapiens	O14908	Y2H Array	11546783

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TGFBR3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74521	TGFBR3/TGF-beta RIII Protein, Human (sf9, His)	Q03167 (G21-G781)	≥95%

Related Diseases

Diseases

Alias

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Priapism

Mentulagra	Priapism, Familial Idiopathic
Familial Idiopathic Priapism	Pathologic Erection
Painful Erection

Familial Cerebral Saccular Aneurysm

Familial Berry Aneurysm

Familial Intracranial Saccular Aneurysm

Glaucoma, Primary Open Angle

Glaucoma 1, Open Angle, E	Primary Open Angle Glaucoma
POAG	Adult-Onset Primary Open Angle Glaucoma
Chronic Simple Glaucoma	GLC1E
Primary Open Angle Glaucoma 1e	Glaucoma, Open Angle, Primary

Disseminated Chorioretinitis

Acquired Hyperkeratosis

Acquired Keratoderma	Keratoderma - Acquired
Keratoderma, Acquired	Keratosis Blennorrhagica

Lipodystrophy, Familial Partial, Type 6

FPLD6	Lipe-Related Familial Partial Lipodystrophy
Familial Partial Lipodystrophy Type 6	Lipe-Related Fpld
Lipodystrophy, Familial Partial, Associated With Lipe Mutations	Familial Partial Lipodystrophy Associated With Lipe Mutations
Lipodystrophy, Familial Partial, 6

Aortic Aneurysm, Familial Thoracic 1

Thoracic Aortic Aneurysm	Annuloaortic Ectasia
Familial Thoracic Aortic Aneurysm And Aortic Dissection	Familial Aortic Dissection
Familial Taad	Congenital Aneurysm Of Ascending Aorta
Familial Aortic Aneurysm	Familial Thoracic Aortic Aneurysm
Familial Thoracic Aortic Aneurysm And Dissection	Aortic Aneurysm, Thoracic
AAT1	Faa1
Aortic Dissection, Familial	Aortic Aneurysm, Familial Thoracic
Aneurysm, Thoracic Aortic	Faa
Ftaad	Taa
Taad	Cystic Medial Necrosis Of Aorta
Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection	Aortic Aneurysm Thoracic
Familial Aortic Aneurysms	Aneurysm, Aortic, Thoracic, Familial, Type 1
Aneurysm Of Thoracic Aorta	Intrathoracic Aneurysm
Thoracic Aorta Aneurysm	Thoracic Aortic Aneurysm Without Rupture
Thoracic Aneurysm	Thorax Arterial Aneurysm
Thoracic Artery Aneurysm	Thoracic Arterial Aneurysm
Thorax Aneurysm	Thorax Aortic Aneurysm
Dissection Of Thoracic Aorta

Pancreatic Cancer

Pancreatic Carcinoma	Familial Pancreatic Carcinoma
Pancreatic Neoplasm	Carcinoma Of Pancreas
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Pancreatic Carcinoma, Somatic	Pancreatic Cancer, Somatic
Ca Body Of Pancreas	Ca Head Of Pancreas
Ca Tail Of Pancreas	Malignant Neoplasm Of Body Of Pancreas
Malignant Neoplasm Of Head Of Pancreas	Malignant Neoplasm Of Tail Of Pancreas
Pancreas Neoplasm	Exocrine Cancer
Exocrine Pancreas Carcinoma	Hereditary Pancreatic Cancer
Hereditary Pancreatic Carcinoma	PNCA
Cancer Of The Pancreas	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14450	TGFBR3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14451	Tgfbr3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14452	Tgfbr3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14453	TGFBR3L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TGFBR3	VGNC	VGNC:66137
Canis familiaris	TGFBR3	VGNC	VGNC:54077
Macaca mulatta	TGFBR3	VGNC	VGNC:78339
Rattus norvegicus	TGFBR3	RGD	RGD:61821
Mus musculus	TGFBR3	MGD	MGI:104637
Bos taurus	TGFBR3	VGNC	VGNC:49979
Others	TGFBR3	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.