ADAM10 - ADAM metallopeptidase domain 10 Gene

Rattus norvegicus

Also known as MADM

Gene ID: 29650 | Gene type: protein coding

About ADAM10

Primary_assembly 8: 71,345,837-71,477,889 forward strand.mRatBN7.2:CM026981.1

This gene has 3 transcripts (splice variants), 371 orthologues, 29 paralogues and is associated with 20 phenotypes. Biased expression in Spleen (RPKM 367.5), Thymus (RPKM 291.3) and 9 other tissues.

Summary

Enables metalloendopeptidase activity. Involved in several processes, including amyloid-beta formation; regulation of dendritic spine morphogenesis; and response to antineoplastic agent. Located in several cellular components, including dendritic spine; synaptic vesicle; and trans-Golgi network. Is active in glutamatergic synapse and postsynapse. Biomarker of Alzheimer's disease; cardiomyopathy; cataract; status epilepticus; and thoracic aortic aneurysm. Human ortholog(s) of this gene implicated in Alzheimer's disease 18 and reticulate acropigmentation of Kitamura. Orthologous to human ADAM10 (ADAM metallopeptidase domain 10). [provided by Alliance of Genome Resources, Apr 2022]

ADAM10 Products(1)

mRNA	Protein	Name
NM_019254.1	NP_062127.1	disintegrin and metalloproteinase domain-containing protein 10 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables metalloendopeptidase activity	IDA IDA: Inferred from direct assay	10423016	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in amyloid-beta formation	IMP IMP: Inferred from mutant phenotype	17301176	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	21503882	RGD
involved in regulation of dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	22328515	RGD
involved in response to antineoplastic agent	IEP IEP: Inferred from expression pattern	21503882	RGD
involved in spermatogenesis	IEP IEP: Inferred from expression pattern	25053185	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	21503882	RGD
located in dendrite	IDA IDA: Inferred from direct assay	25429624	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	17301176	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	17301176	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	25429624	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	17301176	RGD
located in postsynapse	IDA IDA: Inferred from direct assay	22328515	RGD
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	17301176	RGD
located in synaptic vesicle	IDA IDA: Inferred from direct assay	26296617	RGD
located in trans-Golgi network	IDA IDA: Inferred from direct assay	10423016	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADAM10 Protein Structure

Pep_M12B_propep

ZnMc_TACE_like

DISIN

0
200
400
600
749 a.a.

Protein Preferred Names

Protein Names

disintegrin and metalloproteinase domain-containing protein 10

ADAM 10	RGD1566370
a disintegrin and metallopeptidase domain 10	a disintegrin and metalloprotease domain 10
kuzbanian protein homolog	mammalian disintegrin-metalloprotease

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10293	Aderbasib	Inhibitor	99.44%	Phase 2

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-115670	GW280264X	Inhibitor	98.28%	Unkown
HY-110397	KP-457	Inhibitor	99.18%	Unkown
HY-108675	PPNDS tetrasodium	Inhibitor	96.39%	Unkown
HY-120852	JG26	Inhibitor	98.01%	Unkown
HY-P3722A	Mca-PLAQAV-Dpa-RSSSR-NH2 TFA		99.21%	Unkown
HY-P3722	Mca-PLAQAV-Dpa-RSSSR-NH2		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	ADAM10	NCBI	NCBI:102

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