ADAM10 - ADAM metallopeptidase domain 10 Gene

Homo sapiens

Also known as RAK; kuz; AD10; AD18; MADM; CD156c; CDw156; HsT18717

Gene ID: 102 | Gene type: protein coding

About ADAM10

Cytogenetic location: 15q21.3 Genomic coordinates (GRCh38): 15:58,588,809-58,749,707 (from NCBI)

This gene has 17 transcripts (splice variants), 371 orthologues, 20 paralogues and is associated with 3 phenotypes. Ubiquitous expression in urinary bladder (RPKM 30.9), thyroid (RPKM 26.8) and 25 other tissues.

Summary

Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and Protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. Alternate splicing results in multiple transcript variants encoding different proteins that may undergo similar processing. [provided by RefSeq, Feb 2016]

ADAM10 Products(2)

mRNA	Protein	Name
NM_001110.4	NP_001101.1	disintegrin and metalloproteinase domain-containing protein 10 isoform 1 preproprotein
NM_001320570.2	NP_001307499.1	disintegrin and metalloproteinase domain-containing protein 10 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables endopeptidase activity	IMP IMP: Inferred from mutant phenotype	24990881	GOA
enables metalloendopeptidase activity	IDA IDA: Inferred from direct assay	18676862	GOA
enables metalloendopeptidase activity	IMP IMP: Inferred from mutant phenotype	19114711	GOA
enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process	IMP IMP: Inferred from mutant phenotype	28164773	GOA
enables metallopeptidase activity	IDA IDA: Inferred from direct assay	12475894	GOA
enables metallopeptidase activity	IMP IMP: Inferred from mutant phenotype	12535668	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10527948	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	25349418	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in amyloid precursor protein catabolic process	IMP IMP: Inferred from mutant phenotype	28164773	GOA
involved in constitutive protein ectodomain proteolysis	IDA IDA: Inferred from direct assay	12714508	GOA
acts upstream of or within membrane protein ectodomain proteolysis	IDA IDA: Inferred from direct assay	18355449	GOA
involved in membrane protein ectodomain proteolysis	IDA IDA: Inferred from direct assay	12714508	GOA
involved in membrane protein ectodomain proteolysis	IMP IMP: Inferred from mutant phenotype	17965014	GOA
involved in monocyte activation	IMP IMP: Inferred from mutant phenotype	11831872	GOA
involved in negative regulation of cell adhesion	IDA IDA: Inferred from direct assay	12714508	GOA
acts upstream of or within negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24530397	GOA
involved in pore complex assembly	IMP IMP: Inferred from mutant phenotype	30463011	GOA
involved in positive regulation of T cell chemotaxis	IMP IMP: Inferred from mutant phenotype	18373975	GOA
involved in positive regulation of cell growth	IMP IMP: Inferred from mutant phenotype	18373975	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	18373975	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	18373975	GOA
involved in response to tumor necrosis factor	IDA IDA: Inferred from direct assay	11831872	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	12475894	GOA
located in Golgi-associated vesicle	IDA IDA: Inferred from direct assay	12475894	GOA
located in cell surface	IDA IDA: Inferred from direct assay	12475894	GOA
located in perinuclear endoplasmic reticulum	IDA IDA: Inferred from direct assay	23091066	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	20624979	GOA
part of pore complex	IMP IMP: Inferred from mutant phenotype	30463011	GOA
located in synaptic membrane	IDA IDA: Inferred from direct assay	23676497	GOA
located in tetraspanin-enriched microdomain	IDA IDA: Inferred from direct assay	23035126	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADAM10 Protein Structure

Pep_M12B_propep

Reprolysin_2

Disintegrin

0
200
400
600
748 a.a.

Protein Preferred Names

Protein Names

disintegrin and metalloproteinase domain-containing protein 10

a disintegrin and metalloprotease domain 10	kuzbanian protein homolog
mammalian disintegrin-metalloprotease

Related Diseases

Diseases

Alias

Pancreatic Cancer

Pancreatic Carcinoma	Familial Pancreatic Carcinoma
Pancreatic Neoplasm	Carcinoma Of Pancreas
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Pancreatic Carcinoma, Somatic	Pancreatic Cancer, Somatic
Ca Body Of Pancreas	Ca Head Of Pancreas
Ca Tail Of Pancreas	Malignant Neoplasm Of Body Of Pancreas
Malignant Neoplasm Of Head Of Pancreas	Malignant Neoplasm Of Tail Of Pancreas
Pancreas Neoplasm	Exocrine Cancer
Exocrine Pancreas Carcinoma	Hereditary Pancreatic Cancer
Hereditary Pancreatic Carcinoma	PNCA
Cancer Of The Pancreas	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Leech Infestation

Hirudiniasis

Leeches

Scrapie

Down Syndrome

Trisomy 21	Complete Trisomy 21 Syndrome
Down'S Syndrome	Trisomy 21 Syndrome
Down'S Syndrome - Trisomy 21	Downs Syndrome
G Trisomy	47,Xx,+21
47,Xy,+21	Trisomy G
Down Syndrome, Susceptibility To	Chromosome 21 Trisomy
Trisomy 21 Nos	Abnormal Autosomes 21

Alzheimer Disease 18

AD18	Alzheimer'S Disease 18
Alzheimer Disease 18, Late-Onset	Alzheimer Disease 18, Susceptibility To
Alzheimer'S Disease 18, Late Onset	Alzheimer Disease 18 Late-Onset
Alzheimer Disease, Susceptibility To, Type 18

Dowling-Degos Disease 1

Reticular Pigment Anomaly Of Flexures	DDD1
Ddd	Dowling-Degos Disease
Hyperpigmentation

Reticulate Acropigmentation Of Kitamura

RAK	Acropigmentatio Reticularis
Reticulate Pigmentation Of Kitamura	Rpk
Kitamura Reticulate Acropigmentation	Rapk

Purulent Acute Otitis Media

Acute Suppurative Otitis Media	Acute Or Subacute Suppurative Otitis Media
Acute Or Subacute Purulent Otitis Media

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Purpura Fulminans

Purpura Gangrenosa

Cerebral Amyloid Angiopathy, Itm2b-Related, 1

Dementia, Familial British	Fbd
Presenile Dementia With Spastic Ataxia	Familial British Dementia
Abri Amyloidosis	Cerebral Amyloid Angiopathy, British Type
Itm2b-Related Cerebral Amyloid Angiopathy 1	Familial Dementia, British Type
Cerebral Amyloid Angiopathy, Itm2b-Related 1	CAA-ITM2B1
Cerebral Amyloid Angiopathy British Type	Dementia, Familial, British

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Hepatomas
Liver Neoplasm	Liver Carcinoma
Liver And Intrahepatic Biliary Tract Carcinoma	Malignant Hepatobiliary Neoplasm
Adult Primary Hepatocellular Carcinoma	Hepatoblastoma
Carcinoma Of Liver	Malignant Liver Tumour
Malignant Hepatic Tumour

Osteoarthritis

Osteoarthrosis	Degenerative Joint Disease
Hypertrophic Arthritis	Arthropathy
Degenerative Polyarthritis	Degenerative Arthritis
Osteoarthrosis And Allied Disorder	Arthritis, Degenerative
Oa	Osteoarthritis Deformans
Osteoarthrosis Deformans	Kashin-Beck Disease

Fragile X Syndrome

FXS	Martin-Bell Syndrome
Fraxa Syndrome	Marker X Syndrome
X-Linked Mental Retardation And Macroorchidism	Fragile X Mental Retardation Syndrome
Fra Syndrome	Mental Retardation, X-Linked, Associated With Marxq28
Frax Syndrome	Symptomatic Form Of Fragile X Syndrome In Female Carriers
Fragile-X Syndrome	Fraxe Syndrome

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10293	Aderbasib	Inhibitor	98.09%	Phase 2

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-115670	GW280264X	Inhibitor	98.28%	Unkown
HY-110397	KP-457	Inhibitor	99.18%	Unkown
HY-108675	PPNDS tetrasodium	Inhibitor	96.39%	Unkown
HY-120852	JG26	Inhibitor	98.01%	Unkown
HY-P3722A	Mca-PLAQAV-Dpa-RSSSR-NH2 TFA		99.21%	Unkown
HY-P3722	Mca-PLAQAV-Dpa-RSSSR-NH2		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ADAM10	MGD	MGI:109548
Canis familiaris	ADAM10	VGNC	VGNC:59103
Felis catus	ADAM10	VGNC	VGNC:59573
Bos taurus	ADAM10	VGNC	VGNC:25604
Rattus norvegicus	ADAM10	RGD	RGD:2032
Macaca mulatta	ADAM10	VGNC	VGNC:69465
Others	ADAM10	NCBI

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