Slc16a7 - solute carrier family 16 member 7 Gene

Rattus norvegicus

Also known as Mct2

Gene ID: 29735 | Gene type: protein coding

About Slc16a7

Primary_assembly 7: 61,051,167-61,154,994 reverse strand.mRatBN7.2:CM026980.1

This gene has 1 transcript (splice variant), 254 orthologues, 13 paralogues and is associated with 1 phenotype. Biased expression in Kidney (RPKM 249.5), Liver (RPKM 113.8) and 8 other tissues.

Summary

Predicted to enable lactate transmembrane transporter activity and pyruvate transmembrane transporter activity. Involved in plasma membrane lactate transport. Located in cytoplasm and plasma membrane. Is active in several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and parallel fiber to Purkinje cell synapse. Is integral component of postsynaptic density membrane. Orthologous to human SLC16A7 (solute carrier family 16 member 7). [provided by Alliance of Genome Resources, Apr 2022]

Slc16a7 Products(1)

mRNA	Protein	Name
NM_017302.2	NP_058998.2	monocarboxylate transporter 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15917240	RGD
enables symporter activity	IDA IDA: Inferred from direct assay	10417314	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in plasma membrane lactate transport	IDA IDA: Inferred from direct assay	19929853	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	15749979	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	15749979	RGD
is active in hippocampal mossy fiber to CA3 synapse	IDA IDA: Inferred from direct assay	15749979	RGD
is active in parallel fiber to Purkinje cell synapse	IDA IDA: Inferred from direct assay	15749979	RGD
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	15749979	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Slc16a7 Protein Structure

2A0113

0
100
200
300
400
489 a.a.

Protein Preferred Names

Protein Names

monocarboxylate transporter 2

MCT 2	solute carrier family 16 (monocarboxylate transporter), member 7
solute carrier family 16 (monocarboxylic acid transporters), member 7	solute carrier family 16, member 7 (monocarboxylic acid transporter 2)

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13029	SLC16A7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13030	Slc16a7 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13031	Slc16a7 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc16a7	NCBI	NCBI:9194

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