2. Gene
  3. Lag3 - lymphocyte activating 3 Gene

Lag3 - lymphocyte activating 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as CD223

Gene ID: 297596 | Gene type: protein coding

About Lag3

Summary

Predicted to enable MHC class II protein binding activity and transmembrane signaling receptor activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; negative regulation of regulatory T cell differentiation; and plasmacytoid dendritic cell activation. Predicted to act upstream of or within negative regulation of T cell activation; negative regulation of interleukin-2 production; and positive regulation of natural killer cell mediated cytotoxicity. Predicted to be located in external side of plasma membrane and extracellular region. Orthologous to human LAG3 (lymphocyte activating 3). [provided by Alliance of Genome Resources, Apr 2022]

Lag3 Products(1)

mRNA Protein Name
NM_212513.2 NP_997678.2 lymphocyte activation gene 3 protein precursor
Protein Preferred Names Protein Names

lymphocyte activation gene 3 protein

LAG-3

lymphocyte-activation gene 3

Recombinant Lag3 Proteins

Cat. No. Product Name Accession Purity
HY-P74788 LAG-3 Protein, Rat (HEK293, His) Q5BK54 (G24-L442) ≥95%

Related Agents

Clinical Phase
Inhibitory Antibodies (8)
Cat. No. Product Name Effect
Purity Phase
HY-P99156 Relatlimab 98.00% Phase 3
HY-P99573 Tebotelimab 99.52% Phase 3
HY-P99617 Fianlimab 99.04% Phase 3
HY-P99027 Ieramilimab 98.24% Phase 2
HY-P99613 Favezelimab 97.79% Phase 2
HY-P99933 Eftilagimod alfa 95.98% Phase 2
HY-P990046 Tuparstobart / Phase 2
HY-P99736 Miptenalimab / Phase 2
Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-144088 ZYF0033 Inhibitor 98.86% Unkown
HY-162811 LAG-3 biner 1 97.08% Unkown
HY-145240 eIF4E-IN-1 Inhibitor / Unkown
HY-149916 A2AR-antagonist-1 Antagonist / Unkown
HY-P10835 LAG-3 cyclic peptide inhibitor C25 Inhibitor / Unkown
HY-P10837 LAG-3 cyclic peptide inhibitor 12 Inhibitor / Unkown
HY-RS07492 LAG3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-164308 SA-15-P Inhibitor / Unkown
Inhibitory Antibodies (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99141 Anti-Mouse LAG-3 Antibody (C9B7W) 95.00% Unkown
HY-P99922 Encelimab Inhibitor 95.25% Unkown
HY-P990700 Tobemstomig / Unkown
HY-P990912 Cugrastomig / Unkown
HY-P990968 Alcestobart / Unkown
HY-P990976 Brivestobart / Unkown
HY-P99354 Bavunalimab / Unkown
HY-P990204 Anti-Mouse LAG-3 (D265A) Antibody (C9B7W) Inhibitor / Unkown
HY-P990740 Fanastomig / Unkown
HY-P990750 Negalstobart / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lag3 NCBI NCBI:3902
Macaca fascicularis Lag3 NCBI NCBI:102122272
Mus musculus Lag3 NCBI NCBI:16768