GUCA2B - guanylate cyclase activator 2B Gene

Homo sapiens

Also known as UGN; GCAP-II

Gene ID: 2981 | Gene type: protein coding

About GUCA2B

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:42,153,410-42,155,820 (from NCBI)

This gene has 1 transcript (splice variant), 148 orthologues and 1 paralogue. Biased expression in small intestine (RPKM 47.4), colon (RPKM 37.0) and 1 other tissue.

Summary

This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products, including uroguanylin, a member of the guanylin family of Peptides and an endogenous ligand of the guanylate cyclase-C receptor. Binding of this peptide to its cognate receptor stimulates an increase in cyclic GMP and may regulate salt and water homeostasis in the intestine and kidneys. [provided by RefSeq, Nov 2015]

GUCA2B Products(1)

mRNA	Protein	Name
NM_007102.3	NP_009033.1	guanylate cyclase activator 2B preproprotein

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GUCA2B Protein Structure

Guanylin

0
100
112 a.a.

Protein Preferred Names

Protein Names

guanylate cyclase activator 2B

prepro-uroguanylin

GUCA2B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GUCA2B	Q16661	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183
Intra	GUCA2B	Q16661	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	GUCA2B	Q16661	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	GUCA2B	Q16661	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Cataract 8, Multiple Types

Ccv	Cataract, Congenital, Volkmann Type
CTRCT8	Cataract 8 Multiple Types
Cataract Congenital Volkmann Type	Cutaneous Collagenous Vasculopathy

Nephrotic Syndrome

Finnish Congenital Nephrotic Syndrome	Ns - [Nephrotic Syndrome]
Nephrosis Syndrome	Nephrosis Nos
Glomerular Lesion Nephrosis

Secretory Diarrhea

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05917	GUCA2B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GUCA2B	MGD	MGI:1270851
Bos taurus	GUCA2B	VGNC	VGNC:29717
Rattus norvegicus	GUCA2B	RGD	RGD:620044
Felis catus	GUCA2B	VGNC	VGNC:67513
Canis familiaris	GUCA2B	VGNC	VGNC:41565
Macaca mulatta	GUCA2B	VGNC	VGNC:73326

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