2. Gene
  3. GUCY1A1 - guanylate cyclase 1 soluble subunit alpha 1 Gene

GUCY1A1 - guanylate cyclase 1 soluble subunit alpha 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GUCA3; MYMY6; GC-SA3; GUC1A3; GUCSA3; GUCY1A3; GCS-alpha-3; GC-S-alpha-1

Gene ID: 2982 | Gene type: protein coding

About GUCY1A1

Cytogenetic location: 4q32.1 Genomic coordinates (GRCh38): 4:155,666,848-155,737,059 (from NCBI)

This gene has 13 transcripts (splice variants), 203 orthologues, 17 paralogues and is associated with 2 phenotypes. Ubiquitous expression in prostate (RPKM 11.3), heart (RPKM 8.5) and 24 other tissues.

Summary

Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the Guanylate Cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GUCY1A1 Products(18)

mRNA Protein Name
NM_000856.6 NP_000847.2 guanylate cyclase soluble subunit alpha-1 isoform A
NM_001130682.3 NP_001124154.1 guanylate cyclase soluble subunit alpha-1 isoform A
NM_001130683.4 NP_001124155.1 guanylate cyclase soluble subunit alpha-1 isoform A
NM_001130684.3 NP_001124156.1 guanylate cyclase soluble subunit alpha-1 isoform A
NM_001130685.3 NP_001124157.1 guanylate cyclase soluble subunit alpha-1 isoform B
NM_001130687.3 NP_001124159.1 guanylate cyclase soluble subunit alpha-1 isoform D
NM_001256449.2 NP_001243378.1 guanylate cyclase soluble subunit alpha-1 isoform A
NM_001379666.1 NP_001366595.1 guanylate cyclase soluble subunit alpha-1 isoform A
NM_001379667.1 NP_001366596.1 guanylate cyclase soluble subunit alpha-1 isoform A
NM_001379668.1 NP_001366597.1 guanylate cyclase soluble subunit alpha-1 isoform A
NM_001379669.1 NP_001366598.1 guanylate cyclase soluble subunit alpha-1 isoform A
NM_001379670.1 NP_001366599.1 guanylate cyclase soluble subunit alpha-1 isoform A
NM_001379671.1 NP_001366600.1 guanylate cyclase soluble subunit alpha-1 isoform A
NM_001379672.1 NP_001366601.1 guanylate cyclase soluble subunit alpha-1 isoform A
NM_001379673.1 NP_001366602.1 guanylate cyclase soluble subunit alpha-1 isoform A
NM_001379674.1 NP_001366603.1 guanylate cyclase soluble subunit alpha-1 isoform A
NM_001379675.1 NP_001366604.1 guanylate cyclase soluble subunit alpha-1 isoform E
NM_001379676.1 NP_001366605.1 guanylate cyclase soluble subunit alpha-1 isoform F
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables guanylate cyclase activity IDA
IDA: Inferred from direct assay
23505436 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23505436 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cGMP biosynthetic process IDA
IDA: Inferred from direct assay
23505436 GOA
involved in nitric oxide-cGMP-mediated signaling IDA
IDA: Inferred from direct assay
23505436 GOA
Cellular Component GO Annotation Evidence Reference Source
part of guanylate cyclase complex, soluble IDA
IDA: Inferred from direct assay
23505436 GOA
part of guanylate cyclase complex, soluble IPI
IPI: Inferred from physical interaction
23505436 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GUCY1A1 Protein Structure

HNOB

HNOB: Haem-NO-binding (90 - 234)

HNOBA

HNOBA: Heme NO binding associated (273 - 466)

Guanylate_cyc

Guanylate_cyc: Adenylate and Guanylate cyclase catalytic domain (472 - 643)

  • 0
  • 200
  • 400
  • 600
  • 690 a.a.
Protein Preferred Names Protein Names

guanylate cyclase soluble subunit alpha-1

guanylate cyclase 1, soluble, alpha 3

GUCY1A1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
GUCY1A1 Q02108 GUCY1B1 Homo sapiens Q02153
X-Ray Diffraction
23505436
Intra
GUCY1A1 Q02108 GUCY1B1 Homo sapiens Q02153
GTPase Assay
23505436
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Moyamoya Disease 6 With Or Without Achalasia

Moyamoya Disease With Early-Onset Achalasia

MYMY6

Moyamoya 6 With Achalasia

Moyamoya, With Achalasia, Type 6
Moyamoya Disease 1

Moyamoya Disease

Spontaneous Occlusion Of The Circle Of Willis

Mymy

Progressive Intracranial Arterial Occlusion

Moyamoya Syndrome

MYMY1

Cerebrovascular Moyamoya Disease

Moya-Moya Disease

Progressive Intracranial Occlusive Arteropathy

Idiopathic Moyamoya Disease
Myocardial Infarction

Heart Attack

Myocardial Infarction, Susceptibility To

Myocardial Infarction 1

Myocardial Infarction, Protection Against

Myocardial Infarction, Decreased Susceptibility To

Myocardial Infarction, Decreased

Myocardial Infarct

MCI1

Premature Myocardial Infarction

Myocardial Infarction, Susceptibility To, Type 1
Achalasia

Cardiospasm

Achalasia Of Cardia

Esophageal Achalasia

Hypertensive Lower Esophageal Sphincter

Idiopathic Achalasia

Achalasia Cardia

Idiopathic Achalasia Of Esophagus

Primary Achalasia

Achalasia Of Esophagus

Lack Of Reflex Relaxation Of Lower Oesophageal Sphincter

Aperistalsis Of The Oesophagus

Achalasia Of Oesophagus

Oesophageal Achalasia

Achalasia Nos

Cardia Spasm

Cardia Achalasia

Oesophageal Cardiospasm

Oesophagus Achalasia

Reflex Cardiospasm
Bartter Syndrome, Type 2, Antenatal

Bartter Disease Type 2

BARTS2

Hyperprostaglandin E Syndrome 2

Bartter Syndrome, Type 2

Bartter Syndrome Type 2

Hypokalemic Alkalosis With Hypercalciuria Antenatal 2

Hypokalemic Alkalosis With Hypercalciuria 2, Antenatal

Bartter Syndrome Type 2 Antenatal

Hypokalemic Alkalosis With Hypercalciuria 2 Antenatal

Bartter Syndrome Antenatal Type 2

Bartter Syndrome Type Ii

Bartter Syndrome 2, Antenatal

Abs2

Antenatal Bartter Syndrome 2

Bartter Syndrome 2

Bs2

Hyperprostanglandin E Syndrome 2

Bartter Syndrome, Antenatal , Type 2

Antley-Bixler Syndrome, Autosomal Dominant
Hemiplegia

Infantile Hemiplegia

Postnatal Infantile Hemiplegia

Hemiplegia, Infantile
Cerebral Arterial Disease

Cerebral Arterial Diseases
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05918 GUCY1A1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS05920 GUCY1B1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus GUCY1A1 VGNC VGNC:67514
Rattus norvegicus GUCY1A1 RGD RGD:68436
Macaca mulatta GUCY1A1 VGNC VGNC:73327
Mus musculus GUCY1A1 MGD MGI:1926562
Bos taurus GUCY1A1 VGNC VGNC:29720
Canis familiaris GUCY1A1 VGNC VGNC:41567