2. Gene
  3. GUCY1B1 - guanylate cyclase 1 soluble subunit beta 1 Gene

GUCY1B1 - guanylate cyclase 1 soluble subunit beta 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GUCB3; GC-SB3; GUC1B3; GUCSB3; GUCY1B3; GC-S-beta-1

Gene ID: 2983 | Gene type: protein coding

About GUCY1B1

Cytogenetic location: 4q32.1 Genomic coordinates (GRCh38): 4:155,759,021-155,807,811 (from NCBI)

This gene has 8 transcripts (splice variants), 211 orthologues and 17 paralogues. Broad expression in brain (RPKM 21.9), placenta (RPKM 13.8) and 21 other tissues.

Summary

This gene encodes the beta subunit of the soluble Guanylate Cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

GUCY1B1 Products(6)

mRNA Protein Name
NM_000857.5 NP_000848.1 guanylate cyclase soluble subunit beta-1 isoform 2
NM_001291951.3 NP_001278880.1 guanylate cyclase soluble subunit beta-1 isoform 1
NM_001291952.3 NP_001278881.1 guanylate cyclase soluble subunit beta-1 isoform 3
NM_001291953.3 NP_001278882.1 guanylate cyclase soluble subunit beta-1 isoform 4
NM_001291954.3 NP_001278883.1 guanylate cyclase soluble subunit beta-1 isoform 5
NM_001291955.3 NP_001278884.1 guanylate cyclase soluble subunit beta-1 isoform 6

GUCY1B1 Protein Structure

HNOB

HNOB: Haem-NO-binding (1 - 172)

HNOBA

HNOBA: Heme NO binding associated (203 - 406)

Guanylate_cyc

Guanylate_cyc: Adenylate and Guanylate cyclase catalytic domain (413 - 604)

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  • 619 a.a.
Protein Preferred Names Protein Names

guanylate cyclase soluble subunit beta-1

GCS-beta-1

Related Diseases

Diseases Alias
Nemaline Myopathy 7

NEM7

Nemaline Myopathy 7, Autosomal Recessive

Cfl2-Related Nemaline Myopathy

Myopathy, Nemaline, Type 7
Bartter Syndrome, Type 2, Antenatal

Bartter Disease Type 2

BARTS2

Hyperprostaglandin E Syndrome 2

Bartter Syndrome, Type 2

Bartter Syndrome Type 2

Hypokalemic Alkalosis With Hypercalciuria Antenatal 2

Hypokalemic Alkalosis With Hypercalciuria 2, Antenatal

Bartter Syndrome Type 2 Antenatal

Hypokalemic Alkalosis With Hypercalciuria 2 Antenatal

Bartter Syndrome Antenatal Type 2

Bartter Syndrome Type Ii

Bartter Syndrome 2, Antenatal

Abs2

Antenatal Bartter Syndrome 2

Bartter Syndrome 2

Bs2

Hyperprostanglandin E Syndrome 2

Bartter Syndrome, Antenatal , Type 2

Antley-Bixler Syndrome, Autosomal Dominant
Moyamoya Disease 1

Moyamoya Disease

Spontaneous Occlusion Of The Circle Of Willis

Mymy

Progressive Intracranial Arterial Occlusion

Moyamoya Syndrome

MYMY1

Cerebrovascular Moyamoya Disease

Moya-Moya Disease

Progressive Intracranial Occlusive Arteropathy

Idiopathic Moyamoya Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05920 GUCY1B1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus GUCY1B1 VGNC VGNC:29721
Macaca mulatta GUCY1B1 VGNC VGNC:73328
Rattus norvegicus GUCY1B1 RGD RGD:2769
Mus musculus GUCY1B1 MGD MGI:1860604
Canis familiaris GUCY1B1 VGNC VGNC:41568
Felis catus GUCY1B1 VGNC VGNC:67515