TRPM5 - transient receptor potential cation channel subfamily M member 5 Gene

Homo sapiens

Also known as MTR1; LTRPC5

Gene ID: 29850 | Gene type: protein coding

About TRPM5

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:2,403,991-2,444,514 (from NCBI)

This gene has 4 transcripts (splice variants), 205 orthologues and 7 paralogues. Biased expression in duodenum (RPKM 1.1), testis (RPKM 1.1) and 8 other tissues.

Summary

This gene encodes a member of the transient receptor potential (TRP) protein family, which is a diverse group of proteins with structural features typical of ion channels. This protein plays an important role in taste transduction, and has characteristics of a calcium-activated, non-selective cation channel that carries Na+, K+, and Cs+ ions equally well, but not CA(2+) ions. It is activated by lower concentrations of intracellular CA(2+), and inhibited by higher concentrations. It is also a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. This gene is located within the Beckwith-Wiedemann syndrome critical region-1 on chromosome 11p15.5, and has been shown to be imprinted, with exclusive expression from the paternal allele. [provided by RefSeq, Oct 2010]

TRPM5 Products(1)

mRNA	Protein	Name
NM_014555.4	NP_055370.1	transient receptor potential cation channel subfamily M member 5

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium-activated cation channel activity	IDA IDA: Inferred from direct assay	14634208	GOA
enables monoatomic ion channel activity	IDA IDA: Inferred from direct assay	14634208	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables sodium channel activity	IDA IDA: Inferred from direct assay	14634208	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transient receptor potential cation channel subfamily M member 5

MLSN1 and TRP-related

Related Diseases

Diseases

Alias

Beckwith-Wiedemann Syndrome

Wiedemann-Beckwith Syndrome	BWS
Exomphalos-Macroglossia-Gigantism Syndrome	Emg Syndrome
Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation	Emg Abnormality
Wbs	Exomphalos Macroglossia Gigantism Syndrome
Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation	Macroglossia Exomphalos Gigantism

Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques

Olmsted Syndrome	Mutilating Palmoplantar Hyperkeratosis With Periorificial Keratotic Plaques
Palmoplantar And Periorificial Keratoderma	Olms

Autosomal Dominant Polycystic Kidney Disease

Polycystic Kidney Disease, Adult Type	Adpkd
Polycystic Kidney Diseases	Polycystic Kidney, Autosomal Dominant
Congenital Biliary Ectasias	Polycystic Kidney And Hepatic Disease 1
Polycystic Kidney Disease, Autosomal Dominant	Kidney, Polycystic, Disease, Autosomal Dominant
Adult Polycystic Kidney Disease	Polycystic Kidney, Adult Type
Apckd - [Autosomal Polycystic Kidney Disease]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15115	TRPM5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TRPM5	RGD	RGD:1310620
Mus musculus	TRPM5	MGD	MGI:1861718
Bos taurus	TRPM5	VGNC	VGNC:36391
Canis familiaris	TRPM5	VGNC	VGNC:47876
Macaca mulatta	TRPM5	VGNC	VGNC:78955
Felis catus	TRPM5	VGNC	VGNC:82327

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