GUK1 - guanylate kinase 1 Gene

Homo sapiens

Also known as GMK

Gene ID: 2987 | Gene type: protein coding

About GUK1

Cytogenetic location: 1q42.13 Genomic coordinates (GRCh38): 1:228,140,084-228,148,955 (from NCBI)

This gene has 39 transcripts (splice variants) and 306 orthologues. Ubiquitous expression in bone marrow (RPKM 25.0), adrenal (RPKM 18.8) and 25 other tissues.

Summary

The protein encoded by this gene is an Enzyme that catalyzes the transfer of a phosphate group from ATP to guanosine monophosphate (GMP) to form guanosine diphosphate (GDP). The encoded protein is thought to be a good target for Cancer chemotherapy. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

GUK1 Products(5)

mRNA	Protein	Name
NM_000858.7	NP_000849.1	guanylate kinase isoform b
NM_001159390.2	NP_001152862.1	guanylate kinase isoform a
NM_001159391.3	NP_001152863.1	guanylate kinase isoform b
NM_001242839.1	NP_001229768.1	guanylate kinase isoform b
NM_001242840.3	NP_001229769.1	guanylate kinase isoform c

GUK1 Protein Structure

Guanylate_kin

0
100
197 a.a.

Protein Preferred Names

Protein Names

guanylate kinase

ATP:GMP phosphotransferase

Related Diseases

Diseases

Alias

Cataract 6, Multiple Types

Ctpp1	Cataract 6 Multiple Types
CTRCT6	Cataract, Posterior Polar, 1
Arcc2	Cataract, Age-Related Cortical, 2
Ctpa	Ctpp
Age Related Cortical Cataract 2	Posterior Polar Cataract 1
Posterior Polar Cataract, 1	Age-Related Cortical Cataract 2
Cataract Posterior Polar 1

Internal Hordeolum

Cataract 28

CTRCT28	Cataract, Age-Related Cortical, 1
Arcc1	Cataract 28, Age-Related Cortical, Susceptibility To
Cataract 28, Age-Related Cortical	Age-Related Cortical Cataract 1

Brugada Syndrome 4

BRGDA4

Brugada Syndrome, Type 4

Staphyloenterotoxemia

Staphylococcal Food Poisoning	Staphylococcal Toxaemia Due To Food
Staphyloenterotoxicosis

Ankylosis

Orbital Cellulitis

Cellulitis Of Orbit

Acute Orbital Inflammation

Acute Inflammation Of Orbit

Endocardium Disease

Ritter'S Disease

Staphylococcal Scalded Skin Syndrome	Pemphigus Neonatorum
Ritter Disease	Dermatitis Exfoliativa Neonatorum
Scalded Skin Syndrome	Toxic Epidermal Necrolysis, Subcorneal Type
Generalized Exfoliative Disease	Ssss
Ssss - [Staphylococcal Scalded Skin Syndrome]

Commensal Bacterial Infectious Disease

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05924	GUK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	GUK1	VGNC	VGNC:29725
Felis catus	GUK1	VGNC	VGNC:67520
Mus musculus	GUK1	MGD	MGI:95871
Macaca mulatta	GUK1	VGNC	VGNC:73331
Canis familiaris	GUK1	VGNC	VGNC:54767
Rattus norvegicus	GUK1	RGD	RGD:1309638

Name
Email *

	Sorry, but the email address you supplied was invalid.