MYL11 - myosin light chain 11 Gene

Homo sapiens

Also known as DA1C; MLC2B; MRLC2; MYLPF; HUMMLC2B

Gene ID: 29895 | Gene type: protein coding

About MYL11

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:30,370,934-30,377,991 (from NCBI)

This gene has 5 transcripts (splice variants), 251 orthologues, 7 paralogues and is associated with 3 phenotypes. Biased expression in prostate (RPKM 32.5) and esophagus (RPKM 15.3).

Summary

Predicted to be a structural constituent of muscle. Predicted to be involved in skeletal muscle tissue development. Located in lysosomal membrane. Implicated in distal arthrogryposis type 1C. [provided by Alliance of Genome Resources, Apr 2022]

MYL11 Products(3)

mRNA	Protein	Name
NM_001324458.2	NP_001311387.1	myosin regulatory light chain 11
NM_001324459.2	NP_001311388.1	myosin regulatory light chain 11
NM_013292.5	NP_037424.2	myosin regulatory light chain 11

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in muscle contraction	IMP IMP: Inferred from mutant phenotype	32707087	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYL11 Protein Structure

EF-hand_6

0
100
169 a.a.

Protein Preferred Names

Protein Names

myosin regulatory light chain 11

fast skeletal myosin light chain 2

MYL11 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MYL11	Q96A32	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	MYL11	Q96A32	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	MYL11	Q96A32	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	MYL11	Q96A32	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	MYL11	Q96A32	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	MYL11	Q96A32	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	MYL11	Q96A32	GFAP	Homo sapiens	P14136	Y2H Array	32814053
Intra	MYL11	Q96A32	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
Intra	MYL11	Q96A32	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
Intra	MYL11	Q96A32	PEX1	Homo sapiens	O43933	Validated Y2H	32814053
Intra	MYL11	Q96A32	PEX1	Homo sapiens	O43933	Y2H Array	32814053
Intra	MYL11	Q96A32	PEX1	Homo sapiens	O43933	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Arthrogryposis, Distal, Type 1c

DA1C	Distal Arthrogryposis Type 1c
Arthrogryposis, Distal, 1c

Distal Arthrogryposis

Arthrogryposis Multiplex Congenita	Arthrogryposis
Congenital Multiple Arthrogryposis	Congenital Arthromyodysplasia
Fibrous Ankylosis Of Multiple Joints	Guerin-Stern Syndrome
Guérin-Stern Syndrome	Myodystrophia Fetalis Deformans
Otto Syndrome	Rocher-Sheldon Syndrome
Rossi Syndrome	Amc
Multiple Congenital Arthrogryposis	Arthrogryposis Syndrome
Arthrogryposis, Distal	Distal Arthrogryposis Syndrome
Freeman-Sheldon Syndrome	Arthrogryposis, Distal, Type 2b
Congenital Multiplex Arthrogryposis	Amyoplasia Congenita
Congenital Amyoplasia	Amc - [Arthrogryposis Multiplex Congenita]

Congenital Contractures

Congenital Contracture

Scoliosis

Cardiomyopathy, Familial Hypertrophic, 1

Asymmetric Septal Hypertrophy	Familial Hypertrophic Cardiomyopathy
Hypertrophic Cardiomyopathy 1	CMH1
Hypertrophic Cardiomyopathy 19	CMH
Ventricular Hypertrophy, Hereditary	Ash
Hypertrophic Subaortic Stenosis, Idiopathic	Cardiomyopathy, Familial Hypertrophic
Cardiomyopathy, Hypertrophic, 1, Digenic	Cardiomyopathy, Familial Hypertrophic 1
Hcm	Hereditary Ventricular Hypertrophy
Idiopathic Hypertrophic Subaortic Stenosis	Hypertrophic Cardiomyopathy
Cardiomyopathy, Hypertrophic, Familial	Cardiomyopathy, Hypertrophic, 1
Familial Asymmetric Septal Hypertrophy	Heritable Hypertrophic Cardiomyopathy
Fhc	Cardiomyopathy, Hypertrophic, Familial, Type 1

Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy	Cardiomyopathy, Hypertrophic
Cardiomyopathy Hypertrophic Obstructive	Cardiomyopathy, Hypertrophic, Familial
Idiopathic Myocardial Hypertrophy	Idiopathic Hypertrophic Cardiomyopathy
Obstructive Idiopathic Hypertrophic Cardiomyopathy	Obstructive Cardiomyopathy
Idiopathic Hypertrophic Subaortic Stenosis	Muscular Subaortic Stenosis
Hypertrophic Obstructive Subaortic Stenosis

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08911	MYL11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MYL11	VGNC	VGNC:31809
Macaca mulatta	MYL11	VGNC	VGNC:75044
Canis familiaris	MYL11	VGNC	VGNC:43552
Felis catus	MYL11	VGNC	VGNC:63683
Mus musculus	MYL11	MGD	MGI:97273
Rattus norvegicus	MYL11	RGD	RGD:3141

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