SNX11 - sorting nexin 11 Gene

Homo sapiens

Gene ID: 29916 | Gene type: protein coding

About SNX11

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:48,107,523-48,123,601 (from NCBI)

This gene has 13 transcripts (splice variants), 206 orthologues and 15 paralogues. Ubiquitous expression in thyroid (RPKM 9.8), spleen (RPKM 8.3) and 25 other tissues.

Summary

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. This gene encodes a protein of unknown function. This gene results in two transcript variants differing in the 5' UTR, but encoding the same protein. [provided by RefSeq, Jul 2008]

SNX11 Products(3)

mRNA	Protein	Name
NM_001330320.2	NP_001317249.1	sorting nexin-11 isoform 2
NM_013323.3	NP_037455.2	sorting nexin-11 isoform 1
NM_152244.2	NP_689450.1	sorting nexin-11 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphatidylinositol phosphate binding	IDA IDA: Inferred from direct assay	23615901	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in vesicle organization	IMP IMP: Inferred from mutant phenotype	23615901	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	26818531	GOA
located in endosome	IDA IDA: Inferred from direct assay	23615901	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	26818531	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNX11 Protein Structure

0
100
200
270 a.a.

Protein Preferred Names

Protein Names

sorting nexin-11

Related Diseases

Diseases

Alias

Penis Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Penis	Epidermoid Cell Carcinoma Of Penis
Squamous Cell Carcinoma Of The Penis	Penile Squamous Cell Carcinoma

Pyridoxamine 5-Prime-Phosphate Oxidase Deficiency

Pnpo Deficiency	Pyridoxamine 5'-Phosphate Oxidase Deficiency
Pnpo-Related Neonatal Epileptic Encephalopathy	Pyridoxal Phosphate-Responsive Seizures
Pyridoxal 5'-Phosphate-Dependent Epilepsy	Pyridoxine-5'-Phosphate Oxidase Deficiency
PNPOD	Seizures, Pyridoxine-Resistant, Plp-Sensitive
Pyridoxal Phosphate-Dependent Seizures	Pyridoxamine 5'-Oxidase Deficiency
Epileptic Encephalopathy, Neonatal, Pnpo-Related	Pyridox Ine 5'-Phosphate Oxidase Deficiency
Deficiency, Pyridoxamine 5'-Phosphate Oxidase

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13524	SNX11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SNX11	VGNC	VGNC:35092
Rattus norvegicus	SNX11	RGD	RGD:1307319
Mus musculus	SNX11	MGD	MGI:1921729
Macaca mulatta	SNX11	VGNC	VGNC:77706
Felis catus	SNX11	VGNC	VGNC:65542
Canis familiaris	SNX11	VGNC	VGNC:46621

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