2. Gene
  3. Sirt6 - sirtuin 6 Gene

Sirt6 - sirtuin 6 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 299638 | Gene type: protein coding

About Sirt6

Primary_assembly 7: 8,082,364-8,098,914 forward strand.mRatBN7.2:CM026980.1

This gene has 2 transcripts (splice variants), 193 orthologues, 6 paralogues and is associated with 13 phenotypes.

Summary

Enables protein deacetylase activity. Involved in post-embryonic cardiac muscle cell growth involved in heart morphogenesis and response to nutrient levels. Located in cytoplasm and nucleus. Biomarker of non-alcoholic fatty liver disease; obesity; and transient cerebral ischemia. Orthologous to human SIRT6 (Sirtuin 6). [provided by Alliance of Genome Resources, Apr 2022]

Sirt6 Products(1)

mRNA Protein Name
NM_001031649.1 NP_001026819.1 NAD-dependent protein deacetylase sirtuin-6
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
22335191 RGD
enables protein lysine deacetylase activity IDA
IDA: Inferred from direct assay
22335191 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to angiotensin IEP
IEP: Inferred from expression pattern
30894089 RGD
involved in cellular response to endothelin IEP
IEP: Inferred from expression pattern
30894089 RGD
involved in cellular response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
30894089 RGD
involved in post-embryonic cardiac muscle cell growth involved in heart morphogenesis IMP
IMP: Inferred from mutant phenotype
22335191 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
22321393 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NAD-dependent protein deacetylase sirtuin-6

NAD-dependent deacetylase sirtuin-6

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-107454 OSS_128167 Inhibitor 98.63% Unkown
HY-115453 UBCS039 Activator 99.06% Unkown
HY-148712 SIRT6 activator 12q Activator 98.01% Unkown
HY-153104 CrBKA 98.46% Unkown
HY-169159 SIRT6 activator 2 Activator / Unkown
HY-156027 SIRT6-IN-3 Inhibitor 98.19% Unkown
HY-150727 SIRT5 inhibitor 4 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sirt6 NCBI NCBI:51548