2. Gene
  3. SIRT6 - sirtuin 6 Gene

SIRT6 - sirtuin 6 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SIR2L6; hSIRT6

Gene ID: 51548 | Gene type: protein coding

About SIRT6

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,174,109-4,182,563 (from NCBI)

This gene has 15 transcripts (splice variants), 193 orthologues, 6 paralogues and is associated with 1 phenotype. Ubiquitous expression in colon (RPKM 11.3), spleen (RPKM 5.1) and 25 other tissues.

Summary

This gene encodes a member of the Sirtuin family of NAD-dependent Enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

SIRT6 Products(10)

mRNA Protein Name
NM_001321061.2 NP_001307990.1 NAD-dependent protein deacylase sirtuin-6 isoform 6
NM_001321064.2 NP_001307993.1 NAD-dependent protein deacylase sirtuin-6 isoform 9
NM_001321063.2 NP_001307992.1 NAD-dependent protein deacylase sirtuin-6 isoform 8
NM_001321062.2 NP_001307991.1 NAD-dependent protein deacylase sirtuin-6 isoform 7
NM_001321059.2 NP_001307988.1 NAD-dependent protein deacylase sirtuin-6 isoform 4
NM_001321060.2 NP_001307989.1 NAD-dependent protein deacylase sirtuin-6 isoform 5
NM_001321058.2 NP_001307987.1 NAD-dependent protein deacylase sirtuin-6 isoform 3
XM_024451539.2 XP_024307307.1 NAD-dependent protein deacetylase sirtuin-6 isoform X1
NM_016539.4 NP_057623.2 NAD-dependent protein deacylase sirtuin-6 isoform 1
NM_001193285.3 NP_001180214.1 NAD-dependent protein deacylase sirtuin-6 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA binding IMP
IMP: Inferred from mutant phenotype
33067423 GOA
enables DNA damage sensor activity IDA
IDA: Inferred from direct assay
31995034 GOA
enables NAD+-protein ADP-ribosyltransferase activity IDA
IDA: Inferred from direct assay
21680843 GOA
enables NAD-dependent histone H3K18 deacetylase activity IDA
IDA: Inferred from direct assay
27043296 GOA
enables NAD-dependent histone H3K56 deacetylase activity IDA
IDA: Inferred from direct assay
23911928 GOA
enables NAD-dependent histone H3K9 deacetylase activity IDA
IDA: Inferred from direct assay
18337721 GOA
enables NAD-dependent histone H3K9 deacetylase activity IMP
IMP: Inferred from mutant phenotype
29555651 GOA
enables NAD-dependent histone deacetylase activity IDA
IDA: Inferred from direct assay
24043303 GOA
enables NAD-dependent protein demyristoylase activity IDA
IDA: Inferred from direct assay
23552949 GOA
enables NAD-dependent protein depalmitoylase activity IDA
IDA: Inferred from direct assay
23552949 GOA
enables NAD-dependent protein depalmitoylase activity IMP
IMP: Inferred from mutant phenotype
29555651 GOA
enables NAD-dependent protein lysine deacetylase activity IDA
IDA: Inferred from direct assay
19109893 GOA
enables chromatin DNA binding IDA
IDA: Inferred from direct assay
33067423 GOA
enables chromatin binding IDA
IDA: Inferred from direct assay
27043296 GOA
enables chromatin binding IMP
IMP: Inferred from mutant phenotype
33067423 GOA
enables damaged DNA binding IDA
IDA: Inferred from direct assay
31995034 GOA
enables histone H3K9 deacetylase activity EXP
EXP: Inferred from Experiment
33067423 GOA
enables nucleosome binding IDA
IDA: Inferred from direct assay
23892288 GOA
enables nucleosome binding IMP
IMP: Inferred from mutant phenotype
33067423 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19135889 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
31995034 GOA
Biological Process GO Annotation Evidence Reference Source
involved in chromatin remodeling IDA
IDA: Inferred from direct assay
23892288 GOA
involved in determination of adult lifespan IMP
IMP: Inferred from mutant phenotype
25541994 GOA
involved in double-strand break repair IDA
IDA: Inferred from direct assay
21680843 GOA
involved in negative regulation of cellular senescence IDA
IDA: Inferred from direct assay
22753495 GOA
involved in negative regulation of cellular senescence IMP
IMP: Inferred from mutant phenotype
29474172 GOA
involved in negative regulation of gene expression, epigenetic IMP
IMP: Inferred from mutant phenotype
21847107 GOA
involved in negative regulation of gluconeogenesis IDA
IDA: Inferred from direct assay
23142079 GOA
involved in negative regulation of glycolytic process IDA
IDA: Inferred from direct assay
26456828 GOA
involved in negative regulation of protein localization to chromatin IDA
IDA: Inferred from direct assay
27912097 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
24043303 GOA
involved in pericentric heterochromatin formation IDA
IDA: Inferred from direct assay
27043296 GOA
involved in positive regulation of blood vessel branching IMP
IMP: Inferred from mutant phenotype
23201774 GOA
involved in positive regulation of chondrocyte proliferation IMP
IMP: Inferred from mutant phenotype
25819580 GOA
involved in positive regulation of double-strand break repair IDA
IDA: Inferred from direct assay
23911928 GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
27457971 GOA
involved in positive regulation of protein export from nucleus IDA
IDA: Inferred from direct assay
25009184 GOA
involved in positive regulation of stem cell differentiation IDA
IDA: Inferred from direct assay
27912097 GOA
involved in positive regulation of stem cell population maintenance IDA
IDA: Inferred from direct assay
27912097 GOA
involved in positive regulation of telomere maintenance IMP
IMP: Inferred from mutant phenotype
23201774 GOA
involved in positive regulation of vascular endothelial cell proliferation IMP
IMP: Inferred from mutant phenotype
23201774 GOA
involved in protein deacetylation IMP
IMP: Inferred from mutant phenotype
27457971 GOA
involved in protein delipidation IDA
IDA: Inferred from direct assay
23552949 GOA
involved in protein destabilization IDA
IDA: Inferred from direct assay
29474172 GOA
involved in protein destabilization IMP
IMP: Inferred from mutant phenotype
29474172 GOA
involved in protein import into nucleus IDA
IDA: Inferred from direct assay
20117128 GOA
involved in protein import into nucleus IMP
IMP: Inferred from mutant phenotype
20117128 GOA
involved in protein localization to site of double-strand break IDA
IDA: Inferred from direct assay
27568560 GOA
involved in regulation of double-strand break repair via homologous recombination IDA
IDA: Inferred from direct assay
19135889 GOA
involved in regulation of protein localization to plasma membrane IDA
IDA: Inferred from direct assay
28406396 GOA
involved in regulation of protein secretion IDA
IDA: Inferred from direct assay
23552949 GOA
involved in response to UV IDA
IDA: Inferred from direct assay
19109893 GOA
involved in subtelomeric heterochromatin formation IMP
IMP: Inferred from mutant phenotype
21847107 GOA
Cellular Component GO Annotation Evidence Reference Source
located in chromatin IDA
IDA: Inferred from direct assay
23892288 GOA
located in chromosome, subtelomeric region IDA
IDA: Inferred from direct assay
18337721 GOA
is active in endoplasmic reticulum IDA
IDA: Inferred from direct assay
23552949 GOA
NOT located in nucleolus IDA
IDA: Inferred from direct assay
16079181 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
16079181 GOA
is active in nucleus IDA
IDA: Inferred from direct assay
26898756 GOA
located in nucleus IDA
IDA: Inferred from direct assay
25819580 GOA
is active in pericentric heterochromatin IDA
IDA: Inferred from direct assay
27043296 GOA
is active in site of DNA damage IDA
IDA: Inferred from direct assay
19109893 GOA
is active in site of double-strand break IDA
IDA: Inferred from direct assay
21680843 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIRT6 Protein Structure

SIR2

SIR2: Sir2 family (52 - 75)

SIR2

SIR2: Sir2 family (86 - 221)

  • 0
  • 100
  • 200
  • 300
  • 355 a.a.
Protein Preferred Names Protein Names

NAD-dependent protein deacylase sirtuin-6

NAD-dependent protein deacetylase sirtuin-6

SIR2-like protein 6

protein mono-ADP-ribosyltransferase sirtuin-6

regulatory protein SIR2 homolog 6

sir2-related protein type 6

sirtuin type 6

SIRT6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra SIRT6 Q8N6T7 MYC Homo sapiens P01106
Anti Bait CoIP
23217706
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Premature Menopause

Primary Ovarian Insufficiency

Premature Ovarian Failure

Hypergonadotropic Hypogonadism

Premature Ovarian Insufficiency

Menopause - Premature

Menopause Praecox

Menopause Premature

Menopause, Premature

Female Hypergonadotropic Hypogonadism

Hypergonadotrophic Ovarian Failure

Primary Female Hypogonadism

Pof - [Premature Ovarian Failure]

Ovarian Failure

Ovarian Secretion Suppression

Ovary Hyposecretion

Ovary Secretion Deficiency

Premature Menopause Nos
Monckeberg Arteriosclerosis

Monckeberg Medial Calcific Sclerosis
Diabetes Mellitus

Diabetes
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
Lethal Brain And Heart Developmental Defects
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Diabetes Mellitus, Non-Insulin-Dependent

Type 2 Diabetes

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
Osteoporosis

Postmenopausal Osteoporosis

Osteoporosis, Postmenopausal

Bone Mineral Density Quantitative Trait Locus

Bmnd

Osteoporosis, Involutional

Osteoporosis, Susceptibility To

Osteoporosis, Postmenopausal, Susceptibility

Bone Mineral Density Variation Qtl, Osteoporosis

OSTEOP

Involutional Osteoporosis

Senile Osteoporosis

Osteoporosis Postmenopausal

Bone Mineral Density, Quantitative Trait Locus

Osteoporosis, Senile

Idiopathic Osteoporosis

Bone Rarefaction Nos

Type 1 Osteoporosis
Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder
Non-Alcoholic Fatty Liver Disease

Fatty Liver

Non-Alcoholic Fatty Liver

Nafld

Nonalcoholic Fatty Liver Disease

Nonalcoholic Steatohepatitis

Steatosis

Nafl

Nash

Non-Alcoholic Steatohepatitis

Susceptibility To Nonalcoholic Fatty Liver Disease

Steatohepatitis

Fatty Degeneration

Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis

Nafld Without Nash

Nafld Without Mention Of Nash
Pancreatic Cancer

Pancreatic Carcinoma

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Carcinoma Of Pancreas

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Cancer Of The Pancreas

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Obesity , Susceptibility To

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease
Aging
Pulpitis

Pulp Stones

Pulpitis Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-107454 OSS_128167 Inhibitor 98.63% Unkown
HY-115453 UBCS039 Activator 99.06% Unkown
HY-148712 SIRT6 activator 12q Activator 98.01% Unkown
HY-153104 CrBKA 98.46% Unkown
HY-169159 SIRT6 activator 2 Activator / Unkown
HY-156027 SIRT6-IN-3 Inhibitor / Unkown
HY-150727 SIRT5 inhibitor 4 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SIRT6 VGNC VGNC:65160
Rattus norvegicus SIRT6 RGD RGD:1305216
Bos taurus SIRT6 VGNC VGNC:34635
Mus musculus SIRT6 MGD MGI:1354161
Canis familiaris SIRT6 VGNC VGNC:46187
Macaca mulatta SIRT6 VGNC VGNC:77486
Others SIRT6 NCBI