DONSON - DNA replication fork stabilization factor DONSON Gene

Homo sapiens

Also known as B17; MIMIS; MISSLA; C21orf60

Gene ID: 29980 | Gene type: protein coding

About DONSON

Cytogenetic location: 21q22.11 Genomic coordinates (GRCh38): 21:33,577,551-33,588,684 (from NCBI)

This gene has 13 transcripts (splice variants), 209 orthologues and is associated with 4 phenotypes. Broad expression in testis (RPKM 22.3), urinary bladder (RPKM 14.4) and 23 other tissues.

Summary

This gene lies downstream of the SON gene and spans 10 kb on chromosome 21. The function of this gene is unknown. [provided by RefSeq, Jul 2008]

DONSON Products(1)

mRNA	Protein	Name
NM_017613.4	NP_060083.1	protein downstream neighbor of Son

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28191891	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage checkpoint signaling	IMP IMP: Inferred from mutant phenotype	28191891	GOA
involved in DNA replication	IMP IMP: Inferred from mutant phenotype	28191891	GOA
involved in mitotic DNA replication checkpoint signaling	IMP IMP: Inferred from mutant phenotype	28191891	GOA
involved in mitotic G2 DNA damage checkpoint signaling	IMP IMP: Inferred from mutant phenotype	28191891	GOA
involved in replication fork processing	IMP IMP: Inferred from mutant phenotype	28191891	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	28191891	GOA
located in replication fork	IDA IDA: Inferred from direct assay	28191891	GOA
part of replisome	IDA IDA: Inferred from direct assay	28191891	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein downstream neighbor of Son

downstream neighbor of SON

DONSON Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DONSON	Q9NYP3	MCM2	Homo sapiens	P49736	Anti Bait CoIP	32769987
Intra	DONSON	Q9NYP3	MCM2	Homo sapiens	P49736	Anti Tag CoIP	32769987
Intra	DONSON	Q9NYP3	GINS1	Homo sapiens	Q14691	Anti Bait CoIP	32769987
Intra	DONSON	Q9NYP3	GINS1	Homo sapiens	Q14691	Anti Tag CoIP	32769987

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Microcephaly, Short Stature, And Limb Abnormalities

MISSLA	Microcephaly-Short Stature-Limb Abnormalities Syndrome
Microcephaly, Short Stature, Limb Abnormalities

Microcephaly-Micromelia Syndrome

MIMIS

Meier-Gorlin Syndrome 1

Meier-Gorlin Syndrome	Ear, Patella, Short Stature Syndrome
Microtia, Absent Patellae, Micrognathia Syndrome	MGORS1
Eps	Ear-Patella-Short Stature Syndrome
Ear Patella Short Stature Syndrome	Microtia Absent Patellae Micrognathia Syndrome
Meier-Gorlin Syndrome, Type 1

Meier-Gorlin Syndrome 5

MGORS5

Meier-Gorlin Syndrome, Type 5

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Seckel Syndrome

Microcephalic Primordial Dwarfism	Bird-Headed Dwarfism
Harper'S Syndrome	Virchow-Seckel Dwarfism
Nanocephalic Dwarfism	Sckl
Seckel-Type Dwarfism

Intrauterine Growth Retardation, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, And Genital Anomalies

Image Syndrome	IMAGE
Intrauterine Growth Retardation-Metaphyseal Dysplasia-Adrenal Hypoplasia Congenita-Genital Anomalies Syndrome	Intrauterine Growth Restriction, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, And Genital Anomalies
Intrauterine Growth Restriction, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, Genital Abnormalities	Intrauterine Growth Restriction, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, Genital Anomalies
Image Anomaly	Image Association
Fetal Growth Retardation	Pyle Metaphyseal Dysplasia

Isolated Growth Hormone Deficiency, Type Ia

Ighd Ia	Primordial Dwarfism
Isolated Growth Hormone Deficiency Type Ia	Sexual Ateleiotic Dwarfism
Pituitary Dwarfism I	IGHD1A
Illig-Type Growth Hormone Deficiency	Growth Hormone Deficiency, Isolated, Type Ia
Congenital Ighd Type Ia	Congenital Isolated Gh Deficiency Type Ia
Congenital Isolated Growth Hormone Deficiency Type Ia	Pituitary Dwarfism 1
Growth Hormone Deficiency, Isolated, Autosomal Recessive	Autosomal Recessive Isolated Growth Hormone Deficiency
Isolated Growth Hormone Deficiency Type 1a	Congenital Ighd
Congenital Isolated Gh Deficiency	Congenital Isolated Growth Hormone Deficiency
Growth Hormone Deficiency, Isolated Autosomal Recessive	Illig Type Growth Hormone Deficiency
Non-Acquired Isolated Growth Hormone Deficiency	Growth Hormone Deficiency, Isolated, 1a
Growth Hormone Deficiency Isolated Autosomal Recessive	Dwarfism, Primordial
Dwarfism

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly	Mcph
True Microcephaly	Microcephalia Vera
Microcephaly Vera	Microcephaly Primary Hereditary
Microcephaly, Primary, Autosomal Recessive	Primary Microcephaly

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03941	DONSON Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DONSON	VGNC	VGNC:96918
Macaca mulatta	DONSON	VGNC	VGNC:103810
Bos taurus	DONSON	VGNC	VGNC:56216
Rattus norvegicus	DONSON	RGD	RGD:1306823
Mus musculus	DONSON	MGD	MGI:1890621

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