PILRB - paired immunoglobin like type 2 receptor beta Gene

Homo sapiens

Also known as FDFACT1; FDFACT2

Gene ID: 29990 | Gene type: protein coding

About PILRB

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,358,117-100,367,831 (from NCBI)

This gene has 13 transcripts (splice variants), 20 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 49.6), spleen (RPKM 35.1) and 25 other tissues.

Summary

The paired immunoglobin-like type 2 receptors consist of highly related activating and inhibitory receptors that are involved in the regulation of many aspects of the immune system. The paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This gene encodes the activating member of the receptor pair and contains a truncated cytoplasmic tail relative to its inhibitory counterpart (PILRA), that has a long cytoplasmic tail with immunoreceptor tyrosine-based inhibitory (ITIM) motifs. This gene is thought to have arisen from a duplication of the inhibitory PILRA gene and evolved to acquire its activating function. [provided by RefSeq, Jun 2013]

PILRB Products(2)

mRNA	Protein	Name
NM_001371931.2	NP_001358860.1	paired immunoglobulin-like type 2 receptor beta isoform 1 precursor
NM_178238.4	NP_839956.1	paired immunoglobulin-like type 2 receptor beta isoform 2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10660620	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PILRB Protein Structure

V-set

0
100
200
227 a.a.

Protein Preferred Names

Protein Names

paired immunoglobulin-like type 2 receptor beta

activating receptor PILR-beta

Recombinant PILRB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77463	PILR-beta Protein, Human (HEK293, His)	Q9UKJ0-1 (Q20-A189)	≥95%

Related Diseases

Diseases

Alias

Inflammatory Bowel Disease 25

Early Onset Autosomal Recessive Inflammatory Bowel Disease 25	Ibd25
Inflammatory Bowel Disease 25, Autosomal Recessive

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10546	PILRB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PILRB	RGD	RGD:1584675
Mus musculus	PILRB	NCBI

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