OBP2A - odorant binding protein 2A Gene

Homo sapiens

Also known as OBP; LCN13; OBP2C; OBPIIa; hOBPIIa

Gene ID: 29991 | Gene type: protein coding

About OBP2A

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:135,546,126-135,549,969 (from NCBI)

This gene has 7 transcripts (splice variants), 191 orthologues and 12 paralogues. Biased expression in testis (RPKM 2.5), skin (RPKM 0.2) and 1 other tissue.

Summary

This gene encodes a small extracellular protein belonging to the lipocalin superfamily. The protein is thought to transport small, hydrophobic, volatile molecules or odorants through the nasal mucus to olfactory receptors, and may also function as a scavenger of highly concentrated or toxic odors. The protein is expressed as a monomer in the nasal mucus, and can bind diverse types of odorants with a higher affinity for aldehydes and fatty acids. This gene and a highly similar family member are located in a cluster of lipocalin genes on chromosome 9. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

OBP2A Products(4)

mRNA	Protein	Name
NM_001293189.2	NP_001280118.1	odorant-binding protein 2a isoform gamma precursor
NM_001293193.2	NP_001280122.1	odorant-binding protein 2a isoform delta precursor
NM_001412135.1	NP_001399064.1	odorant-binding protein 2a isoform 5 precursor
NM_014582.3	NP_055397.1	odorant-binding protein 2a isoform alpha precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables odorant binding	IDA IDA: Inferred from direct assay	16546182	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OBP2A Protein Structure

Lipocalin

0
100
170 a.a.

Protein Preferred Names

Protein Names

odorant-binding protein 2a

odorant-binding protein IIa

Related Diseases

Diseases

Alias

Trombiculiasis

Syringomyelia

Hydromyelia

Vaginal Discharge

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09735	OBP2A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	OBP2A	RGD	RGD:1588212

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